MicroRNA associated with dyslipidemia and coronary disease in humans

Flowers, Elena; Aouizerat, Bradley E.

doi:10.1152/physiolgenomics.00106.2013

Cited by 6 publications

(4 citation statements)

References 59 publications

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“…Researchers have found three primary mechanisms that facilitate the epimutation of phenotypes that adversely affect cardiovascular disease risk: DNA methylation, modification of core histone proteins, and alteration of microRNA expression. The latter mechanism, microRNAs (miR) expression alterations, is believed to be the most influential of the three [198–201], regulating several CVD-related disease processes, including cardiac hypertrophy, angiogenesis, glucose metabolism, and lipid metabolism [200].…”

Section: Resultsmentioning

confidence: 99%

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

Palaniappan

Garg

Enas³

et al. 2018

J Community Health

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South Asians (SAs) are at heightened risk for cardiovascular disease as compared to other ethnic groups, facing premature and more severe coronary artery disease, and decreased insulin sensitivity. This disease burden can only be partially explained by conventional risk factors, suggesting the need for a specific cardiovascular risk profile for SAs. Current research, as explored through a comprehensive literature review, suggests the existence of population specific genetic risk factors such as lipoprotein(a), as well as population specific gene modulating factors. This review catalogues the available research on cardiovascular disease and genetics, anthropometry, and pathophysiology, and cancer genetics among SAs, with a geographical focus on the U.S. A tailored risk profile will hinge upon population customized classification and treatment guidelines, informed by continued research.

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Section: Resultsmentioning

confidence: 99%

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

Palaniappan

Garg

Enas³

et al. 2018

J Community Health

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“…Dyslipidemia is a complex, multifactorial risk factor for CV disease that arises in the setting of both genetic and environmental exposures. MiRs are an epigenetic mechanism of regulation of gene expression that facilitate dynamic adaptation of organisms to their environment 29. Related to patients having MetS, several circulating miRs were also identified in serum.…”

Section: Discussionmentioning

confidence: 99%

<p>Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients</p>

Zaki

Abulsoud

Elsisi

et al. 2019

DMSO

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Objective: This study aims to evaluate the expression pattern of circulating microRNAs (miR)-486-5p, miR-497, miR-509-5p, and miR-605 in the serum of metabolic syndrome (MetS) Egyptian male patients. Methods: In this study, the circulating miR-486-5p, miR-497, miR509-5p, and miR-605 were amplified and quantitatively detected by quantitative real-time polymerase chain reaction in sera of 55 MetS male patients in comparison to 20 male controls. The level of fasting plasma glucose and triacylglycerol (TAG) were measured using calorimetric assay. Blood pressure was measured using mercuric sphygmomanometer. Anthropometric measurements were done to each individual. Furthermore, MetS patients were defined according to the criteria proposed by the American Heart Association and divided into three groups according to MetS index. Results: The study was performed on three groups and a control group defined as follows: group 1: 15 MetS patients who fulfilled all diagnostic criteria of MetS; group 2: 20 MetS patients with normal blood pressure; group 3: 20 MetS patients with normal TAG levels.The levels of miRs are expressed as [median (IQR)]. miR-486-5-p and miR-497 expression were elevated in group 1 [31.9(49), p˂ 0.0001; 73.1(42.5), p˂ 0.0001], group 2 [36.4(15.7), p˂ 0.0001; 68.3(54.8), p˂ 0.0001], and group (3) [10.8(18.9), p= 0.0014; 27.5(39.7), p= 0.0012]. MiR-509-5p was elevated in groups 1 and 2 [501(468), p= 0.0001], [309(436), p= 0.0006], respectively, while normally expressed in group 3 [0.93(0.077), p= 0.0001]. miR-605 was elevated in groups 1 and 3 [25.4(20.0), p= 0.0018], [54.8(65.8), p˂ 0.0001], while normally expressed in group 2 [0.84(0.67), p˂ 0.0001]. Conclusion: miRs (486-5p, 497, 509-5p, and 605) serum levels were higher in MetS patients than in healthy control subjects; therefore, these serum miRs can serve as early biomarkers and can be used to follow-up the prognosis of MetS.

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“…miRNAs are able to modulate gene expression through posttranscriptional regulation by complementary binding to specific sites within target mRNAs . Several studies have suggested that miRNAs are a significant contributor to the pathogenesis of complex diseases, including insulin resistance, dyslipidemia, and cardiovascular diseases . From the cytoplasm, mature miRNA can be released into circulation, yet exactly how circulating miRNAs potentially influence cellular processes remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Levels of Circulating miR‐122 are Associated with Weight Loss and Metabolic Syndrome

Hess

Larsen

Udesen

et al. 2020

Obesity

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Objective This study investigated whether the levels of specific serum microRNAs (miRNAs) were altered following diet‐induced weight loss and whether the serum miRNAs differed in the presence of the metabolic syndrome. Methods The study was a weight loss intervention trial with a prescribed energy deficit of approximately 500 kcal/d. Levels of 22 miRNAs were determined in serum samples from 85 participants with overweight or obesity. miRNAs were analyzed using TaqMan Array miRNA Cards and normalized to the geometric mean of spiked‐in ath‐miR‐159a and U6 small nuclear RNA using the ΔCT method. Results The average weight loss was 5.7 kg (P < 0.001). miR‐122‐5p (−0.18 ± 0.06 log fold relative to initial, P < 0.01) and miR‐193a‐5p (−0.12 ± 0.04, P < 0.01) levels decreased in response to weight loss. miR‐126a‐3p (0.11 ± 0.04, P = 0.01) and miR‐222‐3p (1.51 ± 0.12, P < 0.001) levels increased. Furthermore, a higher level of miR‐122‐5p was observed at baseline in participants with the metabolic syndrome compared with participants without (0.28 ± 0.08, P < 0.01). Conclusions Changes in circulating miR‐122‐5p, miR‐126a‐3p, miR‐193a‐5p, and miR‐222‐3p in response to diet‐induced weight loss are demonstrated. Furthermore, assessment of miR‐122‐5p could be an indicator of an adverse metabolic health status independent of obesity.

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MicroRNA associated with dyslipidemia and coronary disease in humans

Abstract: Flowers E, Aouizerat BE. MicroRNA associated with dyslipidemia and coronary disease in humans.

Cited by 6 publications

References 59 publications

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

<p>Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients</p>

Levels of Circulating miR‐122 are Associated with Weight Loss and Metabolic Syndrome

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