MicroRNA as biomarkers of mitochondrial toxicity

Baumgart, Bethany R.; Gray, Katherine L.; Woicke, Jochen; Bunch, Roderick T.; Sanderson, Thomas P.; Vleet, Terry R. Van

doi:10.1016/j.taap.2015.10.007

Cited by 12 publications

(10 citation statements)

References 60 publications

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“…microRNAs (miRNAs) are being tested as early and more sensitive biomarkers of drug‐induced toxic injuries as well as in a wide range of human diseases (cardiovascular diseases, metabolic disorders, cancer, etc.). They also can explain the pathogenesis of these toxic injuries …”

Section: Introductionsupporting

confidence: 72%

Serum miR‐122 and miR‐192 as biomarkers of intrinsic and idiosyncratic acute hepatotoxicity: A quantitative real‐time polymerase chain reaction study in adult albino rats

Madboly

Alhusseini

Rahman

et al. 2019

J Biochem & Molecular Tox

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miR-122 and miR-192 were investigated as indicators of toxic liver injury caused by acetaminophen, but their role in idiosyncratic toxic liver injury remains controversial.So, this work aimed to assess and compare the expressions of miR-122 and miR-192 in two different types of toxic liver injury (intrinsic [acetaminophen] and idiosyncratic [diclofenac]). Forty male adult Wistar albino rats were divided into equal five groups, in which serum liver enzymes; microRNAs (miRNAs) expressions (miR-122 and miR-192) and histopathological findings were studied. The present study showed that (1) miR-122 and miR-192 are good serum biomarkers of toxic liver injury whatever its etiology, as their serum levels exhibited a significantly earlier increase and earlier return to normal baseline levels as compared to serum aminotransferase levels;(2) miR-122 is more specific than miR-192; and (3) both serum levels of miR-122 and miR-192 showed non-significant differences in relation to the type of toxic liver injury. K E Y W O R D S biomarkers, hepatotoxicity, idiosyncratic, intrinsic, miR-122, miR-192, real-time polymerase chain reaction J Biochem Mol Toxicol. 2019;33:e22321. wileyonlinelibrary.com/journal/jbt

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Section: Introductionsupporting

confidence: 72%

Serum miR‐122 and miR‐192 as biomarkers of intrinsic and idiosyncratic acute hepatotoxicity: A quantitative real‐time polymerase chain reaction study in adult albino rats

Madboly

Alhusseini

Rahman

et al. 2019

J Biochem & Molecular Tox

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“…Chronic endurance exercise upregulates the tricarboxylic acid cycle and oxidative phosphorylation system while a single bout of exercise affects calcium homeostasis and amino acid metabolism. These changes in energy metabolism provide a potential mechanism for our observations as mitochondrial (dys)function has been shown to affect miRNA expression[ 53 ]. It is also possible that exerciseintensity related changes in endothelial function[ 54 ] or hemodynamics[ 55 ] imposed on the hearts of elite compared to non-elite athletes play a key role in our observations.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs as Biomarkers for Acute Atrial Remodeling in Marathon Runners (The miRathon Study – A Sub-Study of the Munich Marathon Study)

et al. 2016

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IntroductionPhysical activity is beneficial for individual health, but endurance sport is associated with the development of arrhythmias like atrial fibrillation. The underlying mechanisms leading to this increased risk are still not fully understood. MicroRNAs are important mediators of proarrhythmogenic remodeling and have potential value as biomarkers in cardiovascular diseases. Therefore, the objective of our study was to determine the value of circulating microRNAs as potential biomarkers for atrial remodeling in marathon runners (miRathon study).Methods30 marathon runners were recruited into our study and were divided into two age-matched groups depending on the training status: elite (ER, ≥55 km/week, n = 15) and non-elite runners (NER, ≤40 km/week, n = 15). All runners participated in a 10 week training program before the marathon. MiRNA plasma levels were measured at 4 time points: at baseline (V1), after a 10 week training period (V2), immediately after the marathon (V3) and 24h later (V4). Additionally, we obtained clinical data including serum chemistry and echocardiography at each time point.ResultsMiRNA plasma levels were similar in both groups over time with more pronounced changes in ER. After the marathon miR-30a plasma levels increased significantly in both groups. MiR-1 and miR-133a plasma levels also increased but showed significant changes in ER only. 24h after the marathon plasma levels returned to baseline. MiR-26a decreased significantly after the marathon in elite runners only and miR-29b showed a non-significant decrease over time in both groups. In ER miRNA plasma levels showed a significant correlation with LA diameter, in NER miRNA plasma levels did not correlate with echocardiographic parameters.ConclusionMiRNAs were differentially expressed in the plasma of marathon runners with more pronounced changes in ER. Plasma levels in ER correlate with left atrial diameter suggesting that circulating miRNAs could potentially serve as biomarkers of atrial remodeling in athletes.

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“…The expression of miR-1 and miR-133a is increased immediately after marathons, and a negative correlation has been observed in the expression levels of miR-1 and miR-133a with left atrial (LA) diameter immediately after and 24 h after marathons in elite runners (ERs) (Clauss et al, 2016). That research implied that endurance exercise would influence energy metabolism (Clauss et al, 2016) and the increase of miRNAs reflect a latent mechanism behind the observation that mitochondrial dysfunction could affect miRNA expression (Baumgart et al, 2015). Circulating miRNAs could be characterized as potential and novel biomarkers for atrial remodeling.…”

Section: Atrial Remodelingmentioning

confidence: 99%

Exercise Mediates Heart Protection via Non-coding RNAs

Zhang

Feng

et al. 2020

Front. Cell Dev. Biol.

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Cardiovascular diseases (CVDs) have become the central matter of death worldwide and have emerged as a notable concern in the healthcare field. There is accumulating evidence that regular exercise training can be as a reliable and widely favorable approach to prevent the heart from cardiovascular events. Non-coding RNAs (ncRNAs) could act as innovative biomarkers and auspicious therapeutic targets to reduce the incidence of CVDs. In this review, we summarized the regulatory effects of ncRNAs in the cardiac-protection provided by exercise to assess potential therapies for CVDs and disease prevention.

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MicroRNA as biomarkers of mitochondrial toxicity

Cited by 12 publications

References 60 publications

Serum miR‐122 and miR‐192 as biomarkers of intrinsic and idiosyncratic acute hepatotoxicity: A quantitative real‐time polymerase chain reaction study in adult albino rats

Serum miR‐122 and miR‐192 as biomarkers of intrinsic and idiosyncratic acute hepatotoxicity: A quantitative real‐time polymerase chain reaction study in adult albino rats

MicroRNAs as Biomarkers for Acute Atrial Remodeling in Marathon Runners (The miRathon Study – A Sub-Study of the Munich Marathon Study)

Exercise Mediates Heart Protection via Non-coding RNAs

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