microRNA as a therapeutic for ischemic stroke

Todoran, Raluca; Falcione, Sarina; Clarke, Mike; Joy, Twinkle; Boghozian, Roobina; Jickling, Glen C.

doi:10.1016/j.neuint.2023.105487

Cited by 8 publications

(3 citation statements)

References 72 publications

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“…Eight microRNAs from these 14 PH-related microRNAs have been reported as a potential regulator for cerebral ischemia or reperfusion injury in previous studies [19, 22, 32–34]. For example, our study showed that miRNA-126-5p decreased in the peri-infarct of rat MCAO model with PH and in BMECs after OGD/R at 24 hours.…”

Section: Discussionsupporting

confidence: 57%

“…MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, and Wnt signaling pathway were the enriched pathway of these PH-related microRNAs. MicroRNAs contribute to cerebral ischemic injury by regulating oxidative stress, inflammation, apoptosis, and BBB permeability [22,[32][33][34]. In this study, we showed 31 significantly differentially expressed target genes related to immune, inflammation, oxidative stress, and apoptosis which were predicted from these PH-associated microRNAs.…”

Section: Discussionmentioning

confidence: 65%

“…Early BBB disruption predicts HT and poor outcomes in acute stroke patients receiving EVT [16][17][18]. Non-coding RNA can contribute to cerebral ischemia-reperfusion injury and act as non-invasive biomarkers of diagnosis and prognosis for HT in patients with acute stroke [19][20][21][22]. In previous studies, we showed the preliminary results of the microRNA expression profile in rat ischemic hemispheres with HT after mechanical reperfusion using a microRNA array.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNAs and mRNA Regulatory Network of Parenchymal Hematoma after Endovascular Mechanical Reperfusion for Acute Ischemic Stroke in Rat

Zhuang,

Huang,

Qin

et al. 2024

Preprint

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Hemorrhagic transformation after endovascular thrombectomy predicts poor outcomes in acute ischemic stroke with large vessel occlusion. The roles of microRNAs in the pathogenesis of parenchymal hematoma (PH) are still unclear. This study aims to investigate the microRNA and mRNA regulatory network associated with PH after mechanical reperfusion in the animal stroke model and oxygen-glucose deprivation/reoxygenation (OGD/R) model. Twenty-five microRNAs were assessed in the reperfusion-induced hemorrhage model in rats with hyperglycemic conditions receiving 5-hour middle cerebral artery occlusion. Thirteen down-regulated microRNAs (miRNA-29a-5p, miRNA-29c-3p, miRNA-126a-5p, miRNA-132-3p, miRNA-136-3p, miRNA-142-3p, miRNA-153-5p, miRNA-218a-5p, miRNA-219a-2-3p, miRNA-369-5p, miRNA-376a-5p, miRNA-376b-5p, miRNA-383-5p) and one up-regulated microRNA (miRNA-195-3p) were found in rat peri-infarct with PH. Ten of these 14 PH-related microRNAs were significantly differentially expressed in at least two of five models of neuron, astrocyte, microglia, BMEC, and pericyte after OGD/R, consistent with the animal model results. Thirty-one predicted hub target genes were significantly differentially expressed in rat peri-infarct with PH. Forty-nine microRNA-mRNA regulatory axes of PH were revealed, which were related to the mechanisms of oxidative stress, apoptosis, immune, and inflammation. Simultaneously differentially expressed microRNAs and related genes in several cells of the neurovascular unit may serve as valuable targets for PH after endovascular thrombectomy in acute ischemic stroke.

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