2017
DOI: 10.1186/s13578-017-0141-y
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microRNA and thyroid hormone signaling in cardiac and skeletal muscle

Abstract: Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant progress in our understanding of the molecular mechanisms that underlie TH action, it’s widely accepted that TH signaling is regulated at multiple levels. A growing number of discoveries suggest that microRNAs (miRNAs) act as fine-tune regulators of gene expression and adds sophisticated regulatory tiers … Show more

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Cited by 20 publications
(13 citation statements)
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“…Moreover, investigating whether TH acts directly or indirectly on heart regenerative outcome would be a promising line of inquiry. Arguing for a direct action, cardiomyocytes were shown to be TH-responsive in different species, in which a switch between fetal and adult transcriptomic programs is well documented in normal development and pathological conditions (55,56). Given our observations relative to the alteration of ECM dynamics, others cell populations, such as cardiofibroblasts, which are also sensitive to TH action (57), may be relevant to investigate.…”
Section: Discussionmentioning
confidence: 87%
“…Moreover, investigating whether TH acts directly or indirectly on heart regenerative outcome would be a promising line of inquiry. Arguing for a direct action, cardiomyocytes were shown to be TH-responsive in different species, in which a switch between fetal and adult transcriptomic programs is well documented in normal development and pathological conditions (55,56). Given our observations relative to the alteration of ECM dynamics, others cell populations, such as cardiofibroblasts, which are also sensitive to TH action (57), may be relevant to investigate.…”
Section: Discussionmentioning
confidence: 87%
“…MicroRNAs miRs are involved in another mechanism of epigenetic regulation of the TH targeted genes. TH is shown to regulate the levels of miR-206/miR-133b in human skeletal muscles, miR208a in the heart, and miR21 and miR181d in the liver [27]. In a mouse model of myocardial infarction, Dio3 is upregulated in cardiomyocytes to create a local hypothyroid condition to increase the regenerative capacity by switching to the fetal gene program.…”
Section: Histone Modificationsmentioning
confidence: 99%
“…Since exacerbated hypertrophy is observed in absence of β-MHC expression in PTP1B cKO mice, we reasoned that understanding how PTP1B inactivation prevents the expression of β-MHC would shed some light on the molecular pathways underlying the PTP1B cKO hypertrophic phenotype. The MHC switch is regulated by miRNAs and thyroid hormones in development and hypertrophy (38)(39)(40). Hence, we first tested whether miRNA populations were affected by PTP1B inactivation and TAC.…”
Section: Ptp1b Regulates the Association Between Mirna-208b And Ago2 mentioning
confidence: 99%
“…log 2 values relative to sham-operated hearts) (39). MiR-208a and miR-208b, respectively encoded by the myosin genes Myh6 (α-MHC) and Myh7 (β-MHC), mediate actions of thyroid hormone in the heart (40).…”
Section: Ptp1b Regulates the Association Between Mirna-208b And Ago2 mentioning
confidence: 99%
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