MicroRNA and gene networks in human Hodgkin’s lymphoma

Zhu, Minghui; Xu, Zhinan; Wang, Kunhao; Wang, Ning; Zhu, Mingyang; Wang, Shang

doi:10.3892/mmr.2013.1741

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…These short RNAs may be extracted from blood in a non-invasive way, they are robust, survive treatment and endure prolonged storage conditions. Several studies involving the role of miRs in cHL have been reported [42][43][44][45][46][47][48], but very few in the context of an HIV-1 infection [49].…”

Section: Discussionmentioning

confidence: 99%

Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21

Hernández-Walias

Vázquez

Pacheco

et al. 2020

JCM

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The incidence of classical Hodgkin lymphoma (cHL) in the HIV-1 setting has increased 5–25-fold compared to that observed in the general population. This study aimed to determine whether selected micro RNAs (miRs) and other soluble biomarkers and cellular subsets are dysregulated in cHL and could be used as biomarkers. This was a retrospective and longitudinal matched case-control study of 111 Caucasian, HIV-1-infected adult individuals, including 37 individuals with cHL and 74 with no type of cancer. Immunovirological data, plasma exosome-derived miR-16, miR-20a, miR-21, miR-221, miR-223, miR-106a, miR-185, miR-23, miR-30d, miR-222, miR-146a and miR-324, plasma IL-6, sCD14, sCD27, sCD30, sIL-2R, TNFR1, and cell phenotyping of T and B lymphocytes and natural killer (NK) cells were analyzed. Before cHL diagnosis, miR-20a, miR-21, and sCD30 were higher in cHL (p = 0.008, p = 0.009 and p = 0.042, respectively), while miR-16 was down-regulated (p = 0.040). miR-20a and miR-21 were independently associated with cHL (p = 0.049 and p = 0.035, respectively). The combination of miR-20a and miR-21 showed a good AUC value of 0.832 with a moderate likelihood ratio positive (LR+) value of 5.6 and a slight likelihood ratio negative (LR−) value of 0.23. At cHL diagnosis, miR-20a, miR-21 and miR-324 were overexpressed in cHL (p = 0.005, p = 0.024, and p = 0.001, respectively), while miR-223, miR-16, miR-185 and miR-106a were down regulated (p = 0.042, p = 0.007, p = 0.006, and p = 0.002, respectively). In addition, sCD14, sCD27, sCD30 and IL2R levels were higher in these individuals (p = 0.038, p = 0.010, p = 0.030, p = 0.006, respectively). miR-20a was independently associated with cHL (p = 0.011). The diagnostic value of miR-20a showed good AUC value of 0.754 (p = 0.074) with a slight LR+ value of 2 and a slight LR− of 0.25. After chemotherapy, miR-20a was higher in those individuals who had an adverse outcome (p < 0.001), while sCD14 and sCD30 were higher (p < 0.001). A specific signature of miRs and cytokines associated with a subsequent cHL diagnosis was found in this study, especially miR-20a and miR-21. Also, another biomarker signature was found at cHL diagnosis, with a relevant discriminant disease value for miR-20a. Of note, miR-20a expression was higher in those individuals who had an adverse clinical outcome after chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21

Hernández-Walias

Vázquez

Pacheco

et al. 2020

JCM

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“…Difference of the miRNA expressions has been implicated in various malignancies and several miRNAs have been determined associated with pathogenesis of some cancers (13)(14)(15)(16)(17)(18)(19). But there is relatively a few studies reported miRNA expression status in HLs (20)(21)(22)(23)(24). In a recent study, Sánchez-Espiridión et al (21) (11,20,25).…”

Section: Discussionmentioning

confidence: 99%

Expressions of Micro RNA of Mixed Cellularity Hodgkin Lymphomas are Different in Paediatric and Adult Patients

Aktaş¹,

Dınız²,

Ceyhan³

et al. 2017

West Indian Med J

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Objective: MicroRNAs represent an emerging class of small noncoding RNAs that play important roles in the posttranscriptional regulation of gene expression. The aim of this study is evaluation the relevance for microRNA in classical mixed cellularity Hodgkin lymphoma (MCHL) pathogenesis. Methods: Expressions of 157 microRNAs in lymph nodes from 20 pediatric and 20 adult patients with MCHL were analyzed. Results: The mean age was 7.4 years in children and 47.4 years in adults. Most patients were male (70%, n=14) in both groups. Stage III disease (N = 9.45%) was common in pediatric group, while stage II disease (N = 18.90%) in others. Thirty-six cases (90%) were alive, while four (10%) were deceased. With microRNA sequencing it was determined that miR-1273e, miR-4322, miR-5008-5p, and miR-6511b-5p were upregulated, while miR-508-5p was down regulated in only pediatric tumors. Conclusion: These results suggest that microRNAs may play an important role in the biology of pediatric Mixed Cellularity Hodgkin lymphomas and may be useful in developing therapies targeting microRNAs.

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“…Concomitantly, miR-23a, miR-122, miR-93, and miR-144 [ 199 ], miR-582-3p, miR-525-3p, miR-448, miR-512-3p, miR-642a-5p, miR-876-5p, miR-532-3p, miR-654-5p, miR-128, miR-145-5p, miR-15b-5p, miR-328, and miR-660-5p were designated as downregulated [ 200 ]. Other studies that are based on a limited number of samples have no information about age [ 201 ], used data miming [ 202 ], or are centered on different cell lines that are all of adult origin [ 203 , 204 , 205 , 206 ]. Thus, so far, there is no information about dysregulated miRNAs in the pediatric setting.…”

Section: Lymphomasmentioning

confidence: 99%

MiRNA Dysregulation in Childhood Hematological Cancer

Oliveira

Roberto

Baroni

et al. 2018

IJMS

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For decades, cancer biology focused largely on the protein-encoding genes that have clear roles in tumor development or progression: cell-cycle control, apoptotic evasion, genome instability, drug resistance, or signaling pathways that stimulate growth, angiogenesis, or metastasis. MicroRNAs (miRNAs), however, represent one of the more abundant classes of cell modulators in multicellular organisms and largely contribute to regulating gene expression. Many of the ~2500 miRNAs discovered to date in humans regulate vital biological processes, and their aberrant expression results in pathological and malignant outcomes. In this review, we highlight what has been learned about the roles of miRNAs in some of the most common human pediatric leukemias and lymphomas, along with their value as diagnostic/prognostic factors.

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MicroRNA and gene networks in human Hodgkin’s lymphoma

Cited by 6 publications

References 29 publications

Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21

Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21

Expressions of Micro RNA of Mixed Cellularity Hodgkin Lymphomas are Different in Paediatric and Adult Patients

MiRNA Dysregulation in Childhood Hematological Cancer

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