MicroRNA Alterations for Diagnosis, Prognosis, and Treatment of Osteoporosis: A Comprehensive Review and Computational Functional Survey

Hu, Hai; He, Xiaodi; Zhang, Yazhong; Chen, Jiajia; Lin, Yuxin; Shen, Bairong

doi:10.3389/fgene.2020.00181

Cited by 18 publications

(19 citation statements)

References 81 publications

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“…Osteoporosis is most common in post‐menopausal women where reduced circulating estrogen levels lead to an increase in both bone resorption and bone formation. However, the increase in bone resorption predominates leading to a net bone loss 87–89 …”

Section: Role Of Mir‐29 Family In Osteoporosismentioning

confidence: 99%

The role of miR‐29 family in disease

Horita

Farquharson

Stephen

2021

J of Cellular Biochemistry

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MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3’‐untranslated region of messenger RNA to regulate posttranscriptional gene expression. Increasing evidence has identified the miR‐29 family, consisting of miR‐29a, miR‐29b‐1, miR‐29b‐2, and miR‐29c, as key regulators of a number of biological processes. Moreover, their abnormal expression contributes to the etiology of numerous diseases. In the current review, we aimed to summarize the differential expression patterns and functional roles of the miR‐29 family in the etiology of diseases including osteoarthritis, osteoporosis, cardiorenal, and immune disease. Furthermore, we highlight the therapeutic potential of targeting members of miR‐29 family in these diseases. We present miR‐29s as promoters of osteoblast differentiation and apoptosis but suppressors of chondrogenic and osteoclast differentiation, fibrosis, and T cell differentiation, with clear avenues for therapeutic manipulation. Further research will be crucial to identify the precise mechanism of miR‐29 family in these diseases and their full potential in therapeutics.

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Section: Role Of Mir‐29 Family In Osteoporosismentioning

confidence: 99%

The role of miR‐29 family in disease

Horita

Farquharson

Stephen

2021

J of Cellular Biochemistry

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“…Accumulating reports have suggested that miRNAs may serve as biomarkers for OP prediction and prevention. 28 Several differentially expressed miRNAs have been identified for OP diagnosis, such as miR-103-3p, miR-30b-5p, miR-1423p, and miR-328-3p and OP, through animal experiments and analysis. 29 The lncRNA-NEF found in the study of triple-negative breast cancer could regulate miR-155 to affect the development of cancer.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of lncRNA‐NEF regulates the miR‐155/PTEN axis to inhibit adipogenesis and promote osteogenesis

Mao

Liu

2021

The Kaohsiung J of Med Scie

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Osteoporosis is characterized by osteopenia and bone tissue microstructure degradation. Adipose-derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells and have the potential to undergo osteogenesis and bone regeneration. Therefore, ADSCs have the potential to treat osteoporosis, but the molecular mechanism of these cells in the process of osteogenesis and osteoclasts is still not clear. In the present study, we collected serum samples from 10 clinical osteoporosis patients to detect long noncoding RNA-neighboring enhancer of FOXA2 (lncRNA-NEF) and miR-155 expression levels. Half of these patients were senile and half were postmenopausal women, and nine of them have used steroids for a long time, in which ADSCs were cultured and induced to adipogenic and osteogenic differentiations.Quantitative real-time polymerase chain reaction was used to detect the expression of genes in ADSCs. Overexpression of lncRNA-NEF in ADSCs were undertaken to verify its regulatory function on cell osteogenic and adipogenic differentiations. A luciferase activity experiment was performed to determine the relationship between miR-155 and phosphatase and tensin homologue deleted on chromosome 10 (PTEN). The level of lncRNA-NEF was downregulated, and miR-155 was upregulated, in serum samples from patients with clinical osteoporosis. LncRNA-NEF showed different expression levels in the induction of osteogenic or adipogenic differentiation, which increased during osteogenic induction and decreased during adipogenic induction. Overexpression of lncRNA-NEF or downregulation of miR-155 in ADSCs promoted osteogenic differentiation and inhibited adipogenesis progression. PTEN was the direct target of miR-155 and was involved in the regulation of osteogenic differentiation. Overexpression of lncRNA-NEF regulated the miR-155/PTEN axis to inhibit adipogenesis and promote osteogenesis in ADSCs.

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“…OPG, RANK, and RANKL are molecules of the tumor necrosis factor (TNF) and its receptor superfamily [61,62], with a pivotal role in bone metabolism that was discovered at the end of the last century [63,64]. RANKL, also known as osteoprotegerin ligand (OPGL), osteoclast differentiation factor (ODF), TNF-related activation-induced cytokine (TRANCE), or TNFSF11 (TNF ligand superfamily member 11), is a homotrimeric transmembrane protein primarily expressed by osteoblasts, osteocytes, bone marrow stromal cells, and other immune cells, such as activated T cells [61,64,65].…”

Section: Bioactivities and Mechanisms Of Action Of Essential Oilsmentioning

confidence: 99%

Essential Oils for Bone Repair and Regeneration—Mechanisms and Applications

et al. 2021

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Although bone possesses a remarkable capacity for self-remodeling and self-healing of small defects, the continuously increasing growth of bone diseases in the elderly population is becoming a significant burden, affecting individual life quality and society. Conventional treatment options involve surgical procedures for repair and reconstruction, local debridement, autografts or allografts, bone transport, Masquelet’s two-stage reconstructions, and vascularized bone transplants. However, as such approaches often lead to disruptions of bone-regeneration processes and microbial contaminations and are often inefficient, researchers focus on developing bone-regenerative strategies and identifying novel therapeutic agents that could aid the bone-healing process. In this regard, plant-derived biocompounds, especially essential oils (EOs), have received great scientific attention in recent years, owing to their antioxidant, anti-inflammatory, and antimicrobial effects. Current studies focus on either the direct application of EOs on bone tissue or the introduction of EOs as bioactive compounds in bone scaffolds or as coatings for bone implants. Some of the EOs investigated involve St. John’s wort, rosemary, thyme, ylang, white poplar, eucalyptus, lavender, and grape seed. In this context, the present paper aims to provide an overview of the main mechanisms involved in bone repair and regeneration and the potential of EOs to address and enhance these mechanisms.

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MicroRNA Alterations for Diagnosis, Prognosis, and Treatment of Osteoporosis: A Comprehensive Review and Computational Functional Survey

Cited by 18 publications

References 81 publications

The role of miR‐29 family in disease

The role of miR‐29 family in disease

Overexpression of lncRNA‐NEF regulates the miR‐155/PTEN axis to inhibit adipogenesis and promote osteogenesis

Essential Oils for Bone Repair and Regeneration—Mechanisms and Applications

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