MicroRNA: A Signature for the Clinical Progression of Chronic Lymphocytic Leukemia
Yuliya A. Veryaskina,
Sergei E. Titov,
Igor B. Kovynev
et al.
Abstract:Chronic lymphocytic leukemia (CLL) is the most common human leukemia. The disease is caused by abnormal proliferation and development of lymphocytes and their precursors in the blood and bone marrow (BM). Recent studies have shown that the CLL’s clinical course and outcome depend not only on genetic but also epigenetic factors. MicroRNAs (miRNAs) are involved in the development of hematological tumors, including CLL. The aim of this study is to identify the miRNA expression profile in CLL and determine the rol… Show more
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