MicroRNA: a novel implication for damage and protection against ionizing radiation

Chen, Yonglin; Cui, Jian; Gong, Yaqi; Wei, Shuang; Wei, Yuanyun; Liang, Yi

doi:10.1007/s11356-021-12509-5

Cited by 22 publications

(11 citation statements)

References 149 publications

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“…There is always a greater interest in the study of miRNAs as tumor biomarkers and in their role in prognosis and response to therapy. Interestingly, miRNA changes following ionizing radiations have been reported [ 27 , 28 ], thus emphasizing their role in the radiosensitivity and radiation resistance to therapy.…”

Section: Discussionmentioning

confidence: 99%

miRNAs in Serum Exosomes for Differential Diagnosis of Brain Metastases

Catelan

Olioso

Santangelo

et al. 2022

Cancers

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Circulating miRNAs are increasingly studied and proposed as tumor markers with the aim of investigating their role in monitoring the response to therapy as well as the natural evolution of primary or secondary brain tumors. This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR-124-3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs. A total of 105 patients with BMs from primary lung or breast cancer, or melanoma underwent neurosurgery or radiosurgery treatment, and 91 patients with HGGs were enrolled, along with 30 healthy controls. A significant increase in miR-21 expression in serum exosomes was observed in both HGGs and BMs compared with healthy controls; on the other hand, miR-124-3p was significantly decreased in BMs, and it was increased in HGGs. After the surgical or radiosurgical treatment of patients with BMs, a significant reduction in miR-21 was noted with both types of treatments. This study identified a signature of exosomal miRNAs that could be useful as a noninvasive complementary analysis both in the differential diagnosis of BMs from glial tumors and in providing information on tumor evolution over time.

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Section: Discussionmentioning

confidence: 99%

miRNAs in Serum Exosomes for Differential Diagnosis of Brain Metastases

Catelan

Olioso

Santangelo

et al. 2022

Cancers

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“…Certainly, research on the radiosensitizing effect of specific lnRNAs on tumors merits being actively pursued [ 107 ]. This rapidly developing research field is likely to stimulate beneficial applications in radiotherapy [ 108 ].…”

Section: Mitochondria Structure and Function In Normal And Cancer Cellsmentioning

confidence: 99%

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Averbeck

Rodriguez-Lafrasse

2021

IJMS

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Until recently, radiation effects have been considered to be mainly due to nuclear DNA damage and their management by repair mechanisms. However, molecular biology studies reveal that the outcomes of exposures to ionizing radiation (IR) highly depend on activation and regulation through other molecular components of organelles that determine cell survival and proliferation capacities. As typical epigenetic-regulated organelles and central power stations of cells, mitochondria play an important pivotal role in those responses. They direct cellular metabolism, energy supply and homeostasis as well as radiation-induced signaling, cell death, and immunological responses. This review is focused on how energy, dose and quality of IR affect mitochondria-dependent epigenetic and functional control at the cellular and tissue level. Low-dose radiation effects on mitochondria appear to be associated with epigenetic and non-targeted effects involved in genomic instability and adaptive responses, whereas high-dose radiation effects (>1 Gy) concern therapeutic effects of radiation and long-term outcomes involving mitochondria-mediated innate and adaptive immune responses. Both effects depend on radiation quality. For example, the increased efficacy of high linear energy transfer particle radiotherapy, e.g., C-ion radiotherapy, relies on the reduction of anastasis, enhanced mitochondria-mediated apoptosis and immunogenic (antitumor) responses.

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“…Blocking the formation of CDK/Cyclin complexes limits the transition of the cell from phase G1 to phase S and from phase G2 to phase M. MiR-15 family and miR-449 are involved in G2 and G2/M phase arrest. ATM/P53/P21 is another pathway with cell cycle implications and miR-200c, miR-375, and miR-106b controlled this pathway [ 50 , 51 , 52 ]. Also worth mentioning is miR-208a, a radiation-induced mi-RNA that can produce radioresistance by activating the AKT/mTOR pathway [ 50 , 51 , 52 , 53 , 54 ].…”

Section: Mirnas and Cancer-implications In Clinical Practice—focus On...mentioning

confidence: 99%

“…ATM/P53/P21 is another pathway with cell cycle implications and miR-200c, miR-375, and miR-106b controlled this pathway [ 50 , 51 , 52 ]. Also worth mentioning is miR-208a, a radiation-induced mi-RNA that can produce radioresistance by activating the AKT/mTOR pathway [ 50 , 51 , 52 , 53 , 54 ]. A direct or inverse correlation between miRNA and specific proteins, determinants of tumor radiosensitivity in breast cancer, has been identified.…”

Section: Mirnas and Cancer-implications In Clinical Practice—focus On...mentioning

confidence: 99%

“…MiR-208a-modulated radiosensitivity has been demonstrated in both preclinical cell and animal models and miR-208a has been associated with radioresistance and proliferation in lung cancer. In patients with non-small cell lung carcinoma (NSCLC), overexpression of hsa-miR-96-5p and hsa-miR-874-3p associated with irradiation may potentiate the tumoricidal effect, the results being similar to the situation where systemic agents targeting HR and NHEJ pathways are added to radiotherapy [ 50 , 62 ]. PTEN down-regulation has as a consequence the activation of the PI3K/AKT pathway, associated with radioresistance and tumor proliferation.…”

Section: Mirnas and Cancer-implications In Clinical Practice—focus On...mentioning

confidence: 99%

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Micro-RNAs, the Cornerstones of the Future of Radiobiology in Head and Neck Cancers?

Mireștean

Iancu

2022

Current Oncology

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Even though it is only the 6th most common malignancy at the modal level, head and neck cancers are distinguished by a considerable treatment failure rate, especially by locoregional recurrences, the intrinsic tumor radioresistance being one of the causes of this phenomenon. The efforts of radiobiological research of these cancers are oriented towards the identification of biomarkers associated with radioresistance and radiosensitivity in order to modulate the treatment so that the therapeutic benefit is maximum. Micro-RNAs (miRNAs, miRs), small single-stranded non-coding RNA molecules are currently being extensively evaluated as potential biomarkers in numerous diseases, including cancer. The evaluation of the potential of miRNAs to modulate or predict radiosensitivity or radioresistance, to anticipate the risk of recurrence and metastasis, and to differentiate different tumor subtypes is based on multiple mechanisms by which mRNAs control proliferation and apoptosis and interact with cell cycle phases or act as oncogenes with the potential to influence invasion promotion or tumor suppression. A refinement of radiosensitivity based on miRNAs with clinical and radiobiological application in head and neck cancers can lead to a personalization of radiotherapy. Thus, a miRNA signature can anticipate the risk of toxicity associated with chemoradiation, the possibility of obtaining locoregional control after treatment, and the recurrence and distant metastasis risk. The potential of miRNAs as an intrinsic predictor of sensitivity to chemotherapy may also guide the therapeutic decision toward choosing an escalation or de-escalation of concurrent or sequential systemic treatment. The choice of the irradiated dose, the fractional dose, the fractionation scheme, and the refining of the dose-volume constraints depending on the radiosensitivity of each tissue type estimated on a case-by-case basis by miRNAs profile are possible concepts for the future radiotherapy and radiobiology of head and neck cancers.

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MicroRNA: a novel implication for damage and protection against ionizing radiation

Cited by 22 publications

References 149 publications

miRNAs in Serum Exosomes for Differential Diagnosis of Brain Metastases

miRNAs in Serum Exosomes for Differential Diagnosis of Brain Metastases

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Micro-RNAs, the Cornerstones of the Future of Radiobiology in Head and Neck Cancers?

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