MicroRNA-98 is a prognostic factor for asbestos-induced mesothelioma

Kim, Ki‐Hun; Ko, Yeji; Oh, Hyeoncheol; Ha, Mihyang; Kang, Junmo; Kwon, Eun Jung; Kang, Ji Wan; Kim, Youngjoo; Heo, Hye Jin; Kim, Guanghwi; Kim, Jung Won; Kim, Yun Hak

doi:10.1080/15287394.2020.1734891

Cited by 3 publications

(2 citation statements)

References 52 publications

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“… [ 92 ] hsa-miR-98 (Down) Human (Malignant pleural mesothelioma patients), GSE92636 database – – – – Higher expression of miR-98 was associated with poor overall survival in patients with mesothelioma. [ 93 ] miR-126, miR-222, (Up) Human (samples from malignant mesothelioma patients) – HUVECs, BEAS-2B, IMR-90, Met-5A 5 μg/cm 2 EGFR, AKT, ERK, p38, PARP1 Exposed cells to asbestos via activating the EGFR pathway could increase the expression of mentioned miRs [ 94 ] miR-126 (Up), miR-520g (−), miR-222 (Up), miR-205 (−) Human (non–small cell lung cancer patients) – – – – Mentioned-miRNAs could be changed in lung malignancies caused by asbestos. [ 20 ] miR-197-3p (dysregulated) Human – – – Serum levels of miR-197-3p could be dysregulated in workers exposed to asbestos.…”

Section: Interaction Between Mirnas and Arsenic Compoundsmentioning

confidence: 99%

The interaction between miRNAs and hazardous materials

Ghafouri‐Fard

Shoorei

Oskuei

et al. 2023

Non-coding RNA Research

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Section: Interaction Between Mirnas and Arsenic Compoundsmentioning

confidence: 99%

The interaction between miRNAs and hazardous materials

Ghafouri‐Fard

Shoorei

Oskuei

et al. 2023

Non-coding RNA Research

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“…MicroRNAs (miRNAs), a class of non-coding RNAs (15–27 nucleotide RNA molecules), control the expression of mRNA post-transcriptionally by binding to the 3ʹ-untranslated region of mRNA by blocking translation or mRNA degradation [ 14 , 15 ]. As a large number of miRNAs have been discovered with the continuous progress of technology, the importance of miRNA-mRNA regulatory mechanisms in physiological and pathological states is slowly becoming highlighted [ 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Multi-omics analysis revealed TEK and AXIN2 are potential biomarkers in multifocal papillary thyroid cancer

et al. 2022

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Background Papillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant thyroid tumors. This study focused on identifying targets that affect the multifocality of PTC. In a previous study, we determined 158 mRNAs related to multifocality in BRAF-mutated PTC using The Cancer Genome Atlas. Methods We used multi-omics data (miRNAs and mRNAs) to identify the regulatory mechanisms of the investigated mRNAs. miRNA inhibitors were used to determine the relationship between mRNAs and miRNAs. We analyzed the target protein levels in patient sera using ELISA and immunohistochemical staining of patients’ tissues. Results We identified 44 miRNAs that showed a negative correlation with mRNA expression. Using in vitro experiments, we identified four miRNAs that inhibit TEK and/or AXIN2 among the target mRNAs. We also showed that the downregulation of TEK and AXIN2 decreased the proliferation and migration of BRAF ( +) PTC cells. To evaluate the diagnostic ability of multifocal PTC, we examined serum TEK or AXIN2 in unifocal and multifocal PTC patients using ELISA, and showed that the serum TEK in multifocal PTC patients was higher than that in the unifocal PTC patients. The immunohistochemical study showed higher TEK and AXIN2 expression in multifocal PTC than unifocal PTC. Conclusions Both TEK and AXIN2 play a potential role in the multifocality of PTC, and serum TEK may be a diagnostic marker for multifocal PTC.

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Genomics and Functional Genomics of Malignant Pleural Mesothelioma

Çakıroğlu

Şentürk

2020

IJMS

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Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer of the mesothelial cells lining the pleural surface of the chest wall and lung. The etiology of MPM is strongly associated with prior exposure to asbestos fibers, and the median survival rate of the diagnosed patients is approximately one year. Despite the latest advancements in surgical techniques and systemic therapies, currently available treatment modalities of MPM fail to provide long-term survival. The increasing incidence of MPM highlights the need for finding effective treatments. Targeted therapies offer personalized treatments in many cancers. However, targeted therapy in MPM is not recommended by clinical guidelines mainly because of poor target definition. A better understanding of the molecular and cellular mechanisms and the predictors of poor clinical outcomes of MPM is required to identify novel targets and develop precise and effective treatments. Recent advances in the genomics and functional genomics fields have provided groundbreaking insights into the genomic and molecular profiles of MPM and enabled the functional characterization of the genetic alterations. This review provides a comprehensive overview of the relevant literature and highlights the potential of state-of-the-art genomics and functional genomics research to facilitate the development of novel diagnostics and therapeutic modalities in MPM.

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MicroRNA-98 is a prognostic factor for asbestos-induced mesothelioma

Cited by 3 publications

References 52 publications

The interaction between miRNAs and hazardous materials

The interaction between miRNAs and hazardous materials

Multi-omics analysis revealed TEK and AXIN2 are potential biomarkers in multifocal papillary thyroid cancer

Genomics and Functional Genomics of Malignant Pleural Mesothelioma

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