MicroRNA-708 is downregulated in hepatocellular carcinoma and suppresses tumor invasion and migration

Li, Guangjun; Yang, Fang; Xu, Hongwei; Yue, Zhongyi; Fang, Xiangjie; Liu, Jingjing

doi:10.1016/j.biopha.2015.05.010

Cited by 30 publications

(28 citation statements)

References 19 publications

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“…Again, the changes we noted were most evident in the old animals of the long-lived strains, suggesting that increased expression of miR-708-5p may also be a later life effect on longevity. In human cells, hsa-miR-708 has been shown to have a tumor-suppressor function in several human cancer types363738. Reduced expression of hsa-miR-708 expression has also been seen in blood taken from old individuals in comparison to young individuals39.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice

Lee

Burić

George-Pandeth

et al. 2017

Sci Rep

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MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have roles in multiple processes that occur in higher eukaryotes. They act by binding to specific sequences in the 3’ untranslated region of their target genes and causing the transcripts to be degraded by the RNA-induced silencing complex (RISC). MicroRNAs have previously been reported to demonstrate altered expression in several aging phenotypes such as cellular senescence and age itself. Here, we have measured the expression levels of 521 small regulatory microRNAs (miRNAs) in spleen tissue from young and old animals of 6 mouse strains with different median strain lifespans by quantitative real-time PCR. Expression levels of 3 microRNAs were robustly associated with strain lifespan, after correction for multiple statistical testing (miR-203-3p [β-coefficient = −0.6447, p = 4.8 × 10−11], miR-664-3p [β-coefficient = 0.5552, p = 5.1 × 10−8] and miR-708-5p [β-coefficient = 0.4986, p = 1.6 × 10−6]). Pathway analysis of binding sites for these three microRNAs revealed enrichment of target genes involved in key aging and longevity pathways including mTOR, FOXO and MAPK, most of which also demonstrated associations with longevity. Our results suggests that miR-203-3p, miR-664-3p and miR-708-5p may be implicated in pathways determining lifespan in mammals.

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Section: Discussionmentioning

confidence: 99%

MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice

Lee

Burić

George-Pandeth

et al. 2017

Sci Rep

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“…Similar to miR-100, evidence on miR708 is conflicting, with some studies reporting tumour suppressor properties in glioblastoma [115], renal cancer [116], ovarian cancer [117] and hepatocellular carcinoma [118] and others reporting oncogenic properties in bladder [119] and non-small cell lung cancers [120]. One of the most downregulated miRNAs in NB cell lines compared to normal adrenal glands was miR34b/c.…”

Section: Introductionmentioning

confidence: 99%

11q deletion in neuroblastoma: a review of biological and clinical implications

et al. 2017

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Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher disease stage and decreased survival probability. During the last 25 years, extensive efforts have been invested to identify the precise frequency of 11q aberrations in neuroblastoma, the recurrently involved genes, and to understand the molecular mechanisms of 11q deletion, but definitive answers are still unclear. In this review, it is our intent to compile and review the evidence acquired to date on 11q deletion in neuroblastoma.

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“…MicroRNA‐708 (miR‐708), a newly discovered miRNA, has proved to be critical in the regulation of different kinds of tumor. Aberrant miR‐708 expression is closely associated with cell proliferation, migration, invasion, apoptosis, and patient prognosis in renal cell carcinoma, lung adenocarcinoma, hepatocellular carcinoma, ovarian carcinoma, bladder carcinoma, and prostate carcinoma . However, few studies have paid attention to the functions of miR‐708 in breast carcinoma and the molecular regulation mechanism of miR‐708 in breast carcinoma still remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

miR‐708/LSD1 axis regulates the proliferation and invasion of breast cancer cells

Zhao

et al. 2016

Cancer Medicine

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Breast cancer is one of the most common malignant tumors in women worldwide. The microRNAs (miRNAs) are small, noncoding RNAs that regulate various biological processes, including breast cancer. miR‐708 played an important role in a variety of cancers. However, its involvement in breast cancer remains largely unclear. In this study, we found that forced the expression of miR‐708 in breast cancer cell lines decreased cell proliferation and invasion, whereas inhibition of miR‐708 increased cell growth and invasion. miR‐708 could directly target the LSD1 3′UTR to downregulate the expression. Further studies suggested that inhibition of LSD1 could phenocopied function of the miR‐708 overexpression in MDA‐MB‐231 cells .Overexpression of LSD1 could counteract the effects of miR‐708 on the proliferation and invasion. Taken together, the results indicate that miR‐708 may function as a tumor suppressor gene in breast cancer development, and miR‐708/LSD1 axis may be a therapeutic intervention in breast cancer in the future.

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MicroRNA-708 is downregulated in hepatocellular carcinoma and suppresses tumor invasion and migration

Cited by 30 publications

References 19 publications

MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice

MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice

11q deletion in neuroblastoma: a review of biological and clinical implications

miR‐708/LSD1 axis regulates the proliferation and invasion of breast cancer cells

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