MicroRNA-625-3p promotes the proliferation, migration and invasion of thyroid cancer cells by up-regulating astrocyte elevated gene 1

Fang, Lei; Kong, Dedi; Xu, Wei

doi:10.1016/j.biopha.2018.03.043

Cited by 23 publications

(27 citation statements)

References 41 publications

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“…It was also reported that miRNAs would also play important roles in the development of thyroid cancer. Several previous studies showed that miRNAs were dysregulated in thyroid cancer and cell lines and the dysregulated miRNAs would be associated with the diagnosis and prognosis of thyroid cancer [9,10].…”

Section: Introductionmentioning

confidence: 99%

miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cell by targeting ZEB1

Zheng

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Introductionmentioning

confidence: 99%

miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cell by targeting ZEB1

Zheng

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…To do so we focused on miR-625-3p, which we had been previously describing as a circulating biomarker in mesothelioma [13] and GAS5, a long non-coding RNA (lncRNA) that we had functionally characterized in MPM [14]. Additionally, high levels of miR-635-3p are associated with poor response to oxaliplatin in colon cancer [15] and expression of miR-625-3p induces oxaliplatin resistance in colon cancer cells [16] and promotes the proliferation of thyroid cancer cells [17]. The GAS5 gene is a so-called host gene for small nucleolar RNA (snoRNA) and it is encoded at locus 1q25.…”

Section: Introductionmentioning

confidence: 99%

miR-625-3p and lncRNA GAS5 in Liquid Biopsies for Predicting the Outcome of Malignant Pleural Mesothelioma Patients Treated with Neo-Adjuvant Chemotherapy and Surgery

Kresoja‐Rakic

Szpechcinski

Kirschner

et al. 2019

ncRNA

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Combining neo-adjuvant chemotherapy and surgery is part of multimodality treatment of malignant pleural mesothelioma (MPM), but not all patients benefit from this approach. In this exploratory analysis, we investigated the prognostic value of circulating miR-625-3p and lncRNA GAS5 after neo-adjuvant chemotherapy. 36 MPM patients from the SAKK 17/04 trial (NCT00334594), whose blood was available before and after chemotherapy were investigated. RNA was isolated from plasma and reverse transcribed into cDNA. miR-16-5p and β-actin were used as a reference gene for miR-625-3p and GAS5, respectively. After exclusion of samples due to hemolysis or RNA degradation, paired plasma samples from 32 patients before and after chemotherapy were further analyzed. Quantification of miR-625-3p levels in all 64 samples revealed a bimodal distribution and cloning and sequencing of miR-625-3p qPCR product revealed the presence of miR-625-3p isomiRs. Relative change of the circulating miR-625-3p and GAS5 levels after chemotherapy showed that increased circulating miR-625-3p and decreased GAS5 was significantly associated with disease progression (Fisher’s test, p = 0.0393). In addition, decreased levels of circulating GAS5 were significantly associated with shorter overall and progression-free survival. Our exploratory analysis revealed a potential value of circulating non-coding RNA for selection of patients likely to benefit from surgery after platinum-based adjuvant chemotherapy.

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“…This observation indicates that miRNAs may be serve a role in oncogenesis and the progression of cancer (12,13). Alterations in miRNA expression have been reported in PTC and are associated with the occurrence and development of PTC by regulating various cellular behaviours, including cell proliferation, the cell cycle, apoptosis, metastasis, tumour formation and epithelial-mesenchymal transition (14)(15)(16). Thus, investigating the expression pattern and detailed roles of miRNAs in PTC may aid the development of potential therapeutic targets for patients with this malignancy.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑744 suppresses cell proliferation and invasion of papillary thyroid cancer by directly targeting NOB1

Liu

Guo²,

Chai

et al. 2019

Mol Med Report

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MicroRNAs (miRs) serve important roles in the formation and progression of papillary thyroid cancer (PTC) by regulating numerous physiological and pathological behaviours. Thus, investigating the functional roles of specific miRNAs in PTC may contribute in identifying effective therapeutic targets for the management of patients with PTC. miR-744 is emerging as a cancer-associated miRNA in numerous types of human cancers; however, the expression and specific functions of miR-744 in PTC are yet to be determined, and the mechanism underlying the regulatory roles of miR-744 in PTC remains unknown. In the present study, miR-744 expression was significantly decreased in PTC tissues and cell lines, as detected by reverse transcription-quantitative polymerase chain reaction. miR-744 restoration inhibited cell proliferation and invasion in PTC. Bioinformatics analysis predicted NIN1 (RPN12) binding protein 1 homolog (NOB1) as a potential target of miR-744. Subsequent experiments validated NOB1 as a direct target gene of miR-744 in PTC. Furthermore, NOB1 was upregulated in PTC tissues and negatively correlated with miR-744 expression. NOB1 overexpression could counteract miR-744-mediated antitumor effects on PTC cells. In summary, these findings indicated that miR-744 may inhibit the progression of PTC by directly targeting NOB1. The identification of the miR-744/NOB1 axis may provide insight into potential targets for the treatment of patients with PTC and improve their prognosis.

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MicroRNA-625-3p promotes the proliferation, migration and invasion of thyroid cancer cells by up-regulating astrocyte elevated gene 1

Cited by 23 publications

References 41 publications

miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cell by targeting ZEB1

miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cell by targeting ZEB1

miR-625-3p and lncRNA GAS5 in Liquid Biopsies for Predicting the Outcome of Malignant Pleural Mesothelioma Patients Treated with Neo-Adjuvant Chemotherapy and Surgery

MicroRNA‑744 suppresses cell proliferation and invasion of papillary thyroid cancer by directly targeting NOB1

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