MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma

Li, Qian; Lin, Lei; Du, Ye; Hao, Xiaoyan; Zhao, Yuze; Liu, Xuejun

doi:10.3892/mmr.2016.5643

Cited by 28 publications

(31 citation statements)

References 32 publications

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“…QPCR showed similar miR-588 downregulation pattern in in vivo breast carcinomas as in in vitro BC cell lines. These results are in line with a recent study showing that miR-588 was significantly downregulated in human lung cancer [ 19 ], suggesting that miR-588 may be aberrantly and predominantly downregulated in various cancer types.…”

Section: Discussionsupporting

confidence: 92%

“…Then, using the Pearson chi-square test, we discovered that low expression level of miR-588 in BC patient carcinomas was closely correlated with poor prognosis, including advanced TNM stage, positive lymph node metastasis status, and positive estrogen receptor status. A previous study showed that, in patients with lung squamous cell carcinoma, miR-588 was also associated with clinical stage and lymph node metastasis [ 19 ]. Thus, it would be interestingly to learn, through further screening of other carcinoma samples, whether miR-588 may be used a broader biomarker for predicting other types of cancers in addition to breast and lung cancers.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study demonstrated that microRNA-588 (miR-588) was predominantly downregulated in human lung squamous cell carcinoma and was closely correlated with lung cancer patient tumor stage and lymph node invasion [ 19 ]. In addition, it was shown that miR-588 can act as a tumor suppressor in human lung cancer by reversely regulating its downstream target gene of progranulin [ 19 ]. However, the expression pattern, prognostic potential, and function of miR-588 have never been elucidated in human BC.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer

Zhang

et al. 2017

Med Sci Monit

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BackgroundWe explored the expression pattern, prognostic potential, and functional role of microRNA-588 (miR-588) in human breast cancer (BC).Material/MethodsThe expression pattern of miR-588 was assessed by qPCR in BC cell lines and human BC carcinomas. The correlations between miR-588 and BC patients’ clinicopathological characteristics, as well as BC patients’ overall survival, were statistically assessed. In in vitro culture, MCF-7 and MDA-MB-231 cells were infected with lentivirus to overexpress endogenous miR-588. The subsequent effects of miR-588 upregulation on BC cell proliferation and cisplatin chemosensitivity were examined.ResultsmiR-588 was found to be significantly downregulated in both BC cell lines and carcinoma tissues of BC patients. Low expression of miR-588 was closely correlated with BC patients’ poor prognosis of TNM stage, lymph node metastasis, and estrogen receptor status. In addition, patients with low miR-588-expressing carcinomas had much shorter overall survival. In MCF-7 and MDA-MB-231 cells, lentiviral infection induced significant miR-588 upregulation, and miR-588 upregulation had an anti-tumor effect in BC cells by significantly inhibiting cancer proliferation and increasing cisplatin chemosensitivity.ConclusionsmiR-588 is downregulated in BC and its aberrant expression is closely associated with patients’ poor prognosis and overall survival, thus suggesting a biomarker role. miR-588 also has anti-tumor function in BC, making it a potential therapeutic target for BC treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer

Zhang

et al. 2017

Med Sci Monit

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“…Therefore, the investigation of the miR-144 in EVs might present novel biomarkers for the early and accurate diagnosis of HCC and other liver diseases [92]. MiR-141-3p also leads to invasion and metastasis of HCC by the direct targeting of SMAD4 and SGK3 [93,94]. Yu M et al assessed the role of miR-144 in HCC.…”

Section: Mir-144 In Hepatocellular Carcinomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

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“…Another study detected that the levels of miR-141-3p were significantly increased in serum extracellular vehicles (EVs) and liver cancer tissues compared with serum and the distal liver tissues in HCC patients [42]. MiR-141-3p also leads to invasion and metastasis of HCC by direct targeting of SMAD4 and SGK3 [43,44]. Yu M et al assessed the role of miR-144 in HCC.…”

Section: Mir-144 In Hepatocellular Carcinomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target in Cancers

Kooshkaki¹,

Rezaei²,

Rahmati³

et al. 2020

Preprint

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MicroRNAs (miRNAs) are small and non-coding RNAs displaying aberrant expression in the tissue and plasma of cancer patients in comparison to healthy individuals. In past decades, accumulating data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been identified that miRNAs can act either as oncogenes through silencing of tumor inhibitors or tumor suppressor via targeting oncoproteins. MiR-144 is located in chromosomal region 17q11.2 that was widely destroyed in many types of cancers. Several studies revealed that miR-144 has different target genes including rapamycin, zonula occludens1, SFRP1, and ANO1. MiR-144 acts as a tumor suppressor or oncogene by targeting specific genes. In this review, we define the role of miR‐144 and its targets in different cancers and provide understanding in tumor proliferation, migration, and apoptosis.

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MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma

Cited by 28 publications

References 32 publications

MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer

MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

MiR-144: A New Possible Therapeutic Target in Cancers

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