MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)

Zhang, Shu; Zhang, Renwen; Xu, Rui; Shang, Jiaqi; He, Hai‐Tao; Yang, Qing

doi:10.1016/j.gene.2020.144383

Cited by 19 publications

(16 citation statements)

References 41 publications

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“…Furthermore, the authors confirmed the role of miR-574-5p in mice tumor xenografts. In this model, the inhibition of miR-574-5p reduced the expression of CD31, a well-known endothelial cell marker [67].…”

Section: Micrornas Involved In the Hif Pathwaymentioning

confidence: 87%

“…The first study by Zhang et al demonstrated how under hypoxic conditions (GC cells cultured under 2% O 2 or in medium containing CoCl 2 ), HIF-1 elevation leads to an increase in the miR-574-5p expression level in GC cells. The authors suggested that the molecular mechanism involves miR-574-5p activating 44/42 kilodaltons (kDa) mitogen-activated protein kinases (MAPKs) by suppressing the expression of its target gene, PTPN3 (a protein tyrosine phosphorylase), thereby promoting angiogenesis by enhancing the expression of VEGF-A [67]. Furthermore, the authors confirmed the role of miR-574-5p in mice tumor xenografts.…”

Section: Micrornas Involved In the Hif Pathwaymentioning

confidence: 89%

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The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer

Giuppi

Salvia

Evangelista

et al. 2021

Biology

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Gastric cancer (GC) is the fifth most frequently diagnosed malignant tumor and the third highest cause of cancer mortality worldwide. For advanced GC, many novel drugs and combinations have been tested, but results are still disappointing, and the disease is incurable in the majority of cases. In this regard, it is critical to investigate the molecular mechanisms underlying GC development. Angiogenesis is one of the hallmarks of cancer with a fundamental role in GC growth and progression. Ramucirumab, a monoclonal antibody that binds to vascular endothelial growth factor-2 (VEGFR-2), is approved in the treatment of advanced and pretreated GC. However, no predictive biomarkers for ramucirumab have been identified so far. Micro RNAs (miRNAs) are a class of evolutionarily-conserved single-stranded non-coding RNAs that play an important role (via post-transcriptional regulation) in essentially all biologic processes, such as cell proliferation, differentiation, apoptosis, survival, invasion, and migration. In our review, we aimed to analyze the available data on the role of angiogenesis-related miRNAs in GC.

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Section: Micrornas Involved In the Hif Pathwaymentioning

confidence: 87%

Section: Micrornas Involved In the Hif Pathwaymentioning

confidence: 89%

The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer

Giuppi

Salvia

Evangelista

et al. 2021

Biology

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“…For example, miR-215 promoted cell migration and invasion of GC by targeting retinoblastoma tumor suppressor gene 1 [30]. Zhang et al showed that miRNA-574-5p promoted angiogenesis via tyrosine-protein phosphatase nonreceptor type 3 in GC [31]. Wei et al demonstrated that miR-638 regulated cell proliferation via targeting metastasis-associated colon cancer protein 1 [32].…”

Section: Discussionmentioning

confidence: 99%

miR-300/FA2H affects gastric cancer cell proliferation and apoptosis

Hong

Huang

et al. 2020

Open Medicine

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MicroRNA (miR/miRNA) expression disorders play a crucial role in the development of gastric cancer (GC). Increasing evidence has indicated that miRNAs participate in the process of numerous cancers. Previous research has demonstrated that miR-300 acts as a cancer-promoting factor or tumor suppressor in a number of tumors. However, to the best of our knowledge, the effects of miR-300 on GC cells remain largely unknown. The present study investigated the effects of miR-300 on GC cells and analyzed its molecular mechanism. First, reverse transcription–quantitative polymerase chain reaction showed that miR-300 expression was increased in GC tissues and cell lines, with the highest expression observed in human gastric cancer cell line AGS. Subsequent results indicated that fatty acid 2-hydroxylase (FA2H) was a target of miR-300. FA2H-plasmid inhibited AGS cell proliferation and induced apoptosis. Finally, miR-300 inhibitor reduced cell proliferation and induced apoptosis, whereby these effects were reversed by FA2H-small interfering RNA. Therefore, the data demonstrated that miR-300/FA2H might be a new potential biomarker and therapeutic target for GC treatment.

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“…Furthermore, miR-765, which targets several protein-encoding genes involved in angiogenesis and vasculogenic mimicry, is downregulated by hypoxia. The upregulation of miR-574-5p enhanced angiogenesis, suppressed the expression of tyrosine protein phosphatase non-receptor type 3, and enhanced phosphorylation of p44/42 mitogen-activated protein kinases in GC cells in hypoxic environments (55). As a hypoxia-specific miR overexpressed in GC, miR-210 regulated HIF-1α expression, facilitated the epithelial-mesenchymal transition (EMT) and angiogenesis in response to hypoxia during tumorigenesis, and inhibited chemoresistance, invasion and metastasis by targeting homeobox protein Hox-A9 (Hoxa9) (56).…”

Section: The Functions Of Mirs In Regulating Tumor Angiogenesismentioning

confidence: 98%

Regulation of angiogenesis by microRNAs in cancer

Zheng

Hou

2021

Mol Med Rep

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MicroRNAs (miRs) are endogenous, small, non-coding RNA molecules with ~22 nucleotides, and are involved in regulating the expression of multiple genes and controlling cellular functions. miRs serve key roles in angiogenesis by regulating the proliferation, differentiation, apoptosis and migration of endothelial cells. Regulation of angiogenesis is essential for several physiological and pathological processes, particularly for tumor development and progression. Therefore, it is important to investigate the roles served by miRs in angiogenesis as this may aid in discovering novel strategies for treating tumors via modulating angiogenesis. In this review, miRNA biogenesis, regulation and functions are described with new information and corresponding references. In particular, the latest advances in the role of various miRs and their target genes involved in tumor angiogenesis were updated. Next, different signaling pathways by which miRNAs could be regulated in different types of tumor progression were addressed. Furthermore, the potential clinical value of miRs as biomarkers for diagnosing and monitoring the response to therapy, as well as their ability to regulate tumor angiogenesis and the mechanism underlying this regulation, were investigated.

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MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)

Cited by 19 publications

References 41 publications

The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer

The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer

miR-300/FA2H affects gastric cancer cell proliferation and apoptosis

Regulation of angiogenesis by microRNAs in cancer

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