MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/β-catenin signaling pathway

Zhang, Zhejia; Xiao, Qian; Li, Xinying

doi:10.1016/j.prp.2020.152939

Cited by 17 publications

(10 citation statements)

References 32 publications

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“…MiR-574-5p, which functions as a tumor-promoting factor, has been shown to be downregulated, which suppresses cancer cell proliferation, migration and invasion. 34 The present study demonstrated that miR-574-5p was upregulated and served as a positive regulator for cell invasion in NPC cells. One possible explanation is that miR-574-5p enhances target gene expression.…”

Section: Discussionsupporting

confidence: 50%

miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/β-Catenin Pathway

Lin

Chen

Wan

et al. 2020

Technol Cancer Res Treat

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MicroRNAs (miR) are a class of non-coding endogenous RNA molecules that suppress the translation of protein-coding genes by destabilizing target mRNAs. The MiR-574-5p has been reported to be involved in the several types of cancer. However, the expression of miR-574-5p and its mechanism in nasopharyngeal carcinoma (NPC) remain unclear. We found that the expression level of miR-574-5p was significantly increased in the NPC cell lines. We further demonstrated that Forkhead box N3 (FOXN3) was a target gene of miR-574-5p. FOXN3 overexpression and inhibition reversed the promoting or suppressing effect, respectively, of NPC cell proliferation, migration and invasion caused by miR-574-5p. Furthermore, miR-574-5p enhanced the β-catenin and TCF4 protein expression by repressing FOXN3 expression, resulting in the activation of the Wnt/β-catenin signaling pathway, but the activity of the Wnt/β-catenin signaling pathway was inhibited by a miR-574-5p inhibitor or FOXN3 overexpression, which reversed the effect of miR-574-5p. Wound-healing and Transwell assays also showed that miR-574-5p promotes the cell migration and invasion of NPC cells, whereas the promoting effect of miR-574-5p was also reversed by a miR-574-5p inhibitor or FOXN3 overexpression. Collectively, these data suggested that miR-574-5p promotes NPC cell proliferation, migration, and invasion at least partly by targeting the FOXN3/Wnt/β-Catenin signaling pathway.

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Section: Discussionsupporting

confidence: 50%

miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/β-Catenin Pathway

Lin

Chen

Wan

et al. 2020

Technol Cancer Res Treat

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“…В результате было выявлено, что miRNA-574-5p активирует ген FOXN3, который, в свою очередь, вызывает экспрессию белка β-catenin, что способствует прогрессированию рака. Этот новый механизм требует дальнейшего изучения в качестве мишени клинической терапии РЩЖ [53].…”

Section: микрорнк ассоциированные с дифференцированными формами рака щитовидной железыunclassified

Modern concepts of the molecular pathogenesis of thyroid cancer

et al. 2021

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Thyroid cancer remains the most common malignancy of the endocrine system worldwide. The indicators of its morbidity and mortality rates have been increasing rapidly over the last decades. Most cases of differentiated thyroid cancer (follicular and papillary histotypes) are clinically manifested by nodular goiter frequently combined with uncertain results of cytological diagnosis (categories III and IV according to the Bethesda (Bethesda System for Reporting Thyroid Cytopathology) classification). All of that makes it difficult to choose a proper tactic for patient treatment. It is known that the development, progression, invasion, and metastasis of cancer cells are regulated by a variety of molecular mechanisms. This review describes several molecular aspects of thyroid nodules oncogenesis, as well as its most promising diagnostic tumor markers. Following molecular pathways are described in particular: gene mutations, protein tumor markers, and epigenetic effects of micro-RNA, histones, as well as DNA methylation. The study of the pathogenesis of this disease has a prognostic value and contributes to the search for effective therapeutic and diagnostic methods and their improvement. That is why we also reviewed modern test panels aimed at preoperative differential diagnosis of thyroid nodules. Summarizing the results of world research on this topic allows us not only to expand the understanding of the fundamental processes of oncogenesis, but also to outline promising areas for future experimental research projects. All of that together will contribute to developing new prognostic, diagnostic and therapeutic technologies, and as a result, will improve the quality of medical care for patients with thyroid cancer.

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“…miR-574-5p is one of the most well-studied miRNAs that is linked to thyroid carcinomas, FTC and PTC in particular, via Wnt pathway. Up-regulation of miR-574-5p was reported by different groups to promote proliferation, Epithelial-Mesenchymal Transition (EMT), invasion, migration and inhibit apoptosis (63)(64)(65). miR-574-5p exerts its oncogenic effects via targeting Forkhead Box N3 (FOXN3), Quaking protein 5-7 (QKI5-7), and Suppressor of Cancer Cell Invasion (SCAI) transcripts.…”

Section: Wnt-mediated Tumorigenic Effects Of Dysregulated Mirnasmentioning

confidence: 99%

“…Collectively, this results in the activation of the Wnt signalling pathway. This, in turn, up-regulates β-catenin, N-cadherin (a mesenchymal biomarker), Snail, c-Myc, cyclin D1 and survivin proteins (63)(64)(65), leading to downstream oncogenic phenotypes and thyroid cancer development.…”

Section: Wnt-mediated Tumorigenic Effects Of Dysregulated Mirnasmentioning

confidence: 99%

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Tabatabaeian¹,

Yang²,

Tay³

2020

Preprint

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Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer.

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MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/β-catenin signaling pathway

Cited by 17 publications

References 32 publications

miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/β-Catenin Pathway

miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/β-Catenin Pathway

Modern concepts of the molecular pathogenesis of thyroid cancer

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

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