MicroRNA‐543 promotes ovariectomy‐induced osteoporosis through inhibition of AKT/p38 MAPK signaling pathway by targeting YAF2

Li, Xiang; Ning, Lei; Zhao, Xiangde; Wan, Shuanglin

doi:10.1002/jcb.28143

Cited by 10 publications

(8 citation statements)

References 21 publications

(46 reference statements)

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“…In ovariectomized rats, overexpression of miRNA-543 was found to significantly suppress cell growth and promote apoptosis in osteoblasts [ 50 ]. In addition, miRNA-543 upregulation inhibited YAF-2 (YY1-associated factor 2) expression in osteoblasts [ 50 ]. The effects of miRNA-543 were further enhanced by YAF-2 knockdown [ 50 ].…”

Section: The Role Of Micro Rna (Mirna) and Long-non-coding Rna (Lnmentioning

confidence: 99%

“…In addition, miRNA-543 upregulation inhibited YAF-2 (YY1-associated factor 2) expression in osteoblasts [ 50 ]. The effects of miRNA-543 were further enhanced by YAF-2 knockdown [ 50 ]. These findings suggest that inhibiting miRNA-543 could potentially protect osteoblasts against ovariectomy-induced osteoporosis through the AKT/p38 MAPK signaling pathway and targeting YAF2 [ 50 ].…”

Section: The Role Of Micro Rna (Mirna) and Long-non-coding Rna (Lnmentioning

confidence: 99%

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The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis

Chen

2020

IJMS

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Osteoporosis is a major concern worldwide and can be attributed to an imbalance between osteoblastic bone formation and osteoclastic bone resorption due to the natural aging process. Heritable factors account for 60–80% of optimal bone mineralization; however, the finer details of pathogenesis remain to be elucidated. Micro RNA (miRNA) and long-non-coding RNA (lncRNA) are two targets that have recently come into the spotlight due to their ability to control gene expression at the post-transcriptional level and provide epigenetic modification. miRNAs are a class of non-coding RNAs that are approximately 18–25 nucleotides long. It is thought that up to 60% of human protein-coding genes may be regulated by miRNAs. They have been found to regulate gene expression that controls osteoblast-dependent bone formation and osteoclast-related bone remodeling. lncRNAs are highly structured RNA transcripts longer than 200 nucleotides that do not translate into proteins. They have very complex secondary and tertiary structures and the same degradation processes as messenger RNAs. The fact that they have a rapid turnover is due to their sponge function in binding the miRNAs that lead to a degradation of the lncRNA itself. They can act as signaling, decoy, and framework molecules, or as primers. Current evidence suggests that lncRNAs can act as chromatin and transcriptional as well as post-transcriptional regulators. With regards to osteoporosis, lncRNA is thought to be involved in the proliferation, apoptosis, and inflammatory response of the bone. This review, which is based on a systematic appraisal of the current literature, provides current molecular and genetic opinions on the roles of miRNAs and lncRNAs in osteoporosis. Further research into the epigenetic modification and the regulatory roles of these molecules will bring us closer to potential disease-modifying treatment for osteoporosis. However, more issues regarding the detailed actions of miRNAs and lncRNAs in osteoporosis remain unknown and controversial and warrant future investigation.

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Section: The Role Of Micro Rna (Mirna) and Long-non-coding Rna (Lnmentioning

confidence: 99%

Section: The Role Of Micro Rna (Mirna) and Long-non-coding Rna (Lnmentioning

confidence: 99%

The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis

Chen

2020

IJMS

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“…Inhibiting miR-543 can protect osteoblasts by upregulating YY1-associated factor 2 (YAF2) and interfering with the AKT/p38 MAPK signaling pathway, which is beneficial to the diagnosis and treatment of osteoporosis (X. Li, Ning, Zhao, & Wan, 2018 (J. Wang, Kong, et al, 2020).…”

Section: The Role Of Mir-543 In Human Noncancerous Diseasesmentioning

confidence: 99%

The role of miR‐543 in human cancerous and noncancerous diseases

Zhou

Zhao

Duan

2020

Journal Cellular Physiology

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MicroRNA (miRNA) is a noncoding single-stranded RNA molecule that can regulate the posttranscriptional expression level of a gene by binding to the 3′-untranslated region (3′-UTR) of the target messenger RNA. miR-543 is a kind of miRNA, which plays an important role in the occurrence and development of various human cancerous and noncancerous diseases. miR-543 directly or indirectly regulates a large number of downstream target genes and plays an important role in cellular components, biological processes, and molecular functions. In addition, many studies have verified the regulatory mechanism, physiological role, biological function, and prognostic value of miR-543. Therefore, this article reviews the papers published in the past decade and elaborates on the research progress of miR-543 from the aspects of physiology and pathology, especially in cancerous and other noncancerous diseases. In particular, we pay attention to the expression patterns, direct targets, biological functions, related pathways, and prognostic value of miR-543 reported in experimental articles. And by comparing similar research articles, we point out existing controversies in this field to date, so as to facilitate further research in the future.

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“…Microribonucleic acids (microRNAs or miRs) are a type of single-stranded, non-coding and small-molecule RNAs approximately 18-25 nucleotides in length, which are involved in the occurrence and progression of various diseases (7,8). It has been reported that some miRs can participate in bone turnover, bone metabolism and bone development, thereby regulating the occurrence and progression of OP (9)(10)(11). However, whether there is a certain association between miRs and T2DM + OP has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

“…In previous experiments, several miRNAs related to OP have been screened, and it was found that miR-205 had a certain association with T2DM + OP in elderly patients (9)(10)(11). In the present study, therefore, the expression of miR-205 in bone tissues and serum of elderly female patients with T2DM + OP was explored, and the effect of miR-205 on osteogenesis/adipogenesis of bone marrow mesenchymal stem cells (BMSCs) and its specific mechanism in elderly female mice with T2DM + OP were investigated, so as to provide new insight for the clinical treatment of elderly female patients with T2DM + OP.…”

Section: Introductionmentioning

confidence: 99%