MicroRNA‐520c‐3p functions as a novel tumor suppressor in lung adenocarcinoma

Li, Xiaofeng; Fu, Qiang; Li, Hui; Zhu, Lihong; Chen, Wei; Ruan, Tonglei; Xu, Wengui; Yu, Xiaozhou

doi:10.1111/febs.14835

Cited by 25 publications

(19 citation statements)

References 33 publications

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“…Histone methylation also mediates decreased expression of miR-449a via SUZ12 in NSCLC (You et al, 2015). Methylation of the promoter region inhibits the expression of miR-520c-3p, which functions as a novel tumor suppressor in lung adenocarcinoma (Li et al, 2019b). Furthermore, SETDB1 expression can also be regulated by microRNAs.…”

Section: Discussionmentioning

confidence: 99%

SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop

Liu

et al. 2020

Front. Cell Dev. Biol.

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Superoxide dismutase 1(SOD1) is a major antioxidant with oncogenic effects in many human cancers. Although SOD1 is overexpressed in various cancers, the clinical significance and functions of SOD1 in non-small cell lung cancer (NSCLC), particularly the epigenetic regulation of SOD1 in NSCLC carcinogenesis and progression have been less well investigated. In this study, we found that SOD1 expression was upregulated in NSCLC cell lines and tissues. Further, elevated SOD1 expression could promote NSCLC cell proliferation, invasion and migration. While inhibition of SOD1 expression induced NSCLC G1-phase cell cycle arrest and promoted apoptosis. In addition, miR-409-3p could repress SOD1 expression and significantly counteract its oncogenic activities. Bioinformatics analysis indicated that SET domain bifurcated histone lysine methyltransferase1 (SETDB1) was involved in the epigenetic regulation of miR-409-3p and SOD1 expression and functions in NSCLC cells. Identification of this miR-409-3p/SOD1/SETDB1 epigenetic regulatory feedforward loop may provide new insights into further understanding of NSCLC tumorigenesis and progression. Additionally, our results incicate that SOD1 may be a potential new therapeutic target for NSCLC treatment.

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Section: Discussionmentioning

confidence: 99%

SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop

Liu

et al. 2020

Front. Cell Dev. Biol.

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“…Further, the tumor suppressive role of YY1 in lung cancer was also evidenced by the finding that YY1 binds to the promoter of tumor suppressor microRNA-520c-3p and enhances its expression. Enhanced expression of miR-520c-3p inhibits tumor progression by negatively regulating AKT1 and AKT2 (130). Such contrasting roles of YY1 both as a tumor promoter and tumor suppressor is puzzling and further work is required to gain a complete mechanistic insight into these opposing functions of YY1.…”

Section: Lung Cancermentioning

confidence: 99%

The Two Sides of YY1 in Cancer: A Friend and a Foe

2019

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Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional activation and repression of many genes associated with multiple cellular processes including cellular differentiation, DNA repair, autophagy, cell survival vs. apoptosis, and cell division. Owing to its role in processes that upon deregulation are linked to malignant transformation, YY1 has been implicated as a major driver of many cancers. While a large body of evidence supports the role of YY1 as a tumor promoter, recent reports indicated that YY1 also functions as a tumor suppressor. The mechanism by which YY1 brings out opposing outcome in tumor growth vs. suppression is not completely clear and some of the recent reports have provided significant insight into this. Likewise, the mechanism by which YY1 functions both as a transcriptional activator and repressor is not completely clear. It is likely that the proteins with which YY1 interacts might determine its function as an activator or repressor of transcription as well as its role as a tumor suppressor or promoter. Hence, a collection of YY1-protein interactions in the context of different cancers would help us gain an insight into how YY1 promotes or suppresses cancers. This review focuses on the YY1 interacting partners and its target genes in different cancer models. Finally, we discuss the possibility of therapeutically targeting the YY1 in cancers where it functions as a tumor promoter.

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“…For example, miRNA-520c-3p is expressed at low levels at the tumour site and negatively regulates the biological behaviour of cancer cells through binding to Akt1 and Akt2. 17 MiRNA-126-3p and miRNA-126-5p are involved in the progression of LUAD and are positively associated with the TNM stage and metastasis. 18 In recent years, accumulating evidence has suggested that competing endogenous RNA (ceRNA) competitively binds to miRNA to regulate miRNA or mRNA expression.…”

Section: Mir-mentioning

confidence: 97%

“…miRNAs control tumour cell stemness and metastasis by acting either as oncogenes or as tumour suppressors. For example, miRNA‐520c‐3p is expressed at low levels at the tumour site and negatively regulates the biological behaviour of cancer cells through binding to Akt1 and Akt2 17 . MiRNA‐126‐3p and miRNA‐126‐5p are involved in the progression of LUAD and are positively associated with the TNM stage and metastasis 18 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of a non‐coding RNA‐associated ceRNA network in metastatic lung adenocarcinoma

Fan

Yü

et al. 2020

J Cellular Molecular Medi

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Lung cancer is one of the most common cancers in the world and has received much attention in recent years due to its association with high morbidity and mortality. 1 In 2018, the World Health Organization reported the estimated morbidity and mortality associated with lung cancer to be about 11.6% and 18.4%, respectively; in China, its incidence and mortality remain high in both men and women. 2 Lung cancer has two main subtypes, small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Based on pathology, NSCLC has various subtypes, such as adenocarcinoma (LUAD), squamous carcinoma (LUSD) and adenosquamous carcinoma. LUAD, one of the most malignant cancers, is often diagnosed at a late stage and has a poor clinical prognosis. 3 In addition, it has been reported that LUAD is associated with a high degree of tumour metastasis. 4,5 Therefore, it is of extreme importance to research the factors associated with lung cancer progression and its poor clinical prognosis.

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MicroRNA‐520c‐3p functions as a novel tumor suppressor in lung adenocarcinoma

Cited by 25 publications

References 33 publications

SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop

SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop

The Two Sides of YY1 in Cancer: A Friend and a Foe

Characterization of a non‐coding RNA‐associated ceRNA network in metastatic lung adenocarcinoma

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