MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN-γ-Induced B7-H1 Expression in Cholangiocytes

Gong, Ai Yu; Zhou, Rui; Hu, Guoku; Li, Xiaoqing; Splinter, Patrick L.; O’Hara, Steven P.; LaRusso, Nicholas F.; Soukup, Garrett A.; Dong, Haidong; Chen, Xian Ming

doi:10.4049/jimmunol.182.3.1325

Cited by 193 publications

(184 citation statements)

References 36 publications

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“…Although miR-513a-5p was not among the reported miRNAs with changed expression levels (38), we found that it interacted with certain alleles of CHST3, reducing its expression. miR-513a-5p also has a negative effect on the mRNA level of B7-H1 (also known as CD274 or programmed death receptor-1 [PD-1] ligand-1) in biliary epithelial cells (cholangiocytes) (39). B7-H1 is a key member of the B7 costimulator family with important regulatory functions in cell-mediated immune responses (40).…”

Section: Discussionmentioning

confidence: 99%

“…B7-H1 is a key member of the B7 costimulator family with important regulatory functions in cell-mediated immune responses (40). miR-513a-5p binds to a site in the B7-H1 3′UTR, resulting in translational repression (39). The expression of miR-513a-5p itself can be downregulated by IFN-γ (39), a proinflammatory cytokine that can mediate many cellular events in cholangiocytes (41).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant

Song¹,

Karasugi²,

Cheung³

et al. 2013

J. Clin. Invest.

117

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Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects many people worldwide. A hallmark of LDD is loss of proteoglycan and water content in the nucleus pulposus of intervertebral discs. While some genetic determinants have been reported, the etiology of LDD is largely unknown. Here we report the findings from linkage and association studies on a total of 32,642 subjects consisting of 4,043 LDD cases and 28,599 control subjects. We identified carbohydrate sulfotransferase 3 (CHST3), an enzyme that catalyzes proteoglycan sulfation, as a susceptibility gene for LDD. The strongest genome-wide linkage peak encompassed CHST3 from a Southern Chinese family-based data set, while a genome-wide association was observed at rs4148941 in the gene in a meta-analysis using multiethnic population cohorts. rs4148941 lies within a potential microRNA-513a-5p (miR-513a-5p) binding site. Interaction between miR-513a-5p and mRNA transcribed from the susceptibility allele (A allele) of rs4148941 was enhanced in vitro compared with transcripts from other alleles. Additionally, expression of CHST3 mRNA was significantly reduced in the intervertebral disc cells of human subjects carrying the A allele of rs4148941. Together, our data provide new insights into the etiology of LDD, implicating an interplay between genetic risk factors and miRNA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant

Song¹,

Karasugi²,

Cheung³

et al. 2013

J. Clin. Invest.

117

View full text Add to dashboard Cite

show abstract

“…IFN-g induces B7-H1 protein expression and alters miRNA expression profile in cholangiocytes. Of those IFN-g-down-regulated miRNAs, miR-513 has complementarity to the 3'-UTR of B7-H1 and targeting of miR-513 to B7-H1 mRNA results in translational repression, but not B7-H1 mRNA degradation [33] .…”

Section: Atlas Adult Fetal Atlas Adult Fetalmentioning

confidence: 99%

MicroRNA signatures in liver diseases

Chen¹

2009

WJG

Self Cite

120

118

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MicroRNAs (miRNAs) are an emerging class of highly conserved non-coding small RNAs that regulate gene expression at the post-transcriptional level. It is now clear that miRNAs can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death, viral infection and tumorigenesis. Recent studies provide clear evidence that miRNAs are abundant in the liver and modulate a diverse spectrum of liver functions. Deregulation of miRNA expression may be a key pathogenetic factor in many liver diseases including viral hepatitis, hepatocellular cancer and polycystic liver diseases. A clearer understanding of the mechanisms involved in miRNA deregulation will offer new diagnostic and therapeutic strategies to treat liver diseases. Moreover, better understanding of miRNA regulation and identification of tissue-specific miRNA targets employing transgenic/knockout models and/or modulating oligonucleotides will improve our knowledge of liver physiology and diseases.

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“…miRNA-513 targets B7-H1 and inhibits its expression by translational repression [89]. In this context, Tamura and coworkers identified an association between low expression of B7-H2 and the escape from immune surveillance indicating that B7-H2 has a potential role in tumorigenesis.…”

Section: Control Of B7 Family Members By Mirnamentioning

confidence: 99%

The Role of Immune Modulatory MicroRNAs in Tumors

Seliger¹,

Meinhardt²,

Falke³

2016

RNA Interference

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Tumors could evade the control of CD8 + T and/or NK cell-mediated surveillance by distinct immune escape strategies. These include the aberrant expression of HLA class I antigens, coinhibitory or costimulatory molecules, and components of the interferon (IFN) signal transduction pathway. In addition, alterations of the tumor microenvironment could interfere with a proper antitumoral immune response by downregulating or inhibiting the frequency and/or activity of immune effector cells and professional antigen presenting cells. Based on the identification as major mediators of the posttranscriptional silencing of gene expression, microRNAs (miRNAs) have been suggested to play a key role in many biological processes known to be involved in neoplastic transformation. Indeed, miRNA expression is frequently deregulated in many cancer types and could have tumor-suppressive as well as oncogenic potential. This review focused on the characterization of miRNAs, which are involved in the control of the immune surveillance or immune escape of tumors and their use as potential diagnostic and prognostic biomarkers as well as therapeutic targets. Moreover, miRNAs can have dual activities by affecting the neoplastic and immunogenic phenotype of tumors.

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MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN-γ-Induced B7-H1 Expression in Cholangiocytes

Cited by 193 publications

References 36 publications

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant

Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant

MicroRNA signatures in liver diseases

The Role of Immune Modulatory MicroRNAs in Tumors

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