MicroRNA-505 identified from patients with essential hypertension impairs endothelial cell migration and tube formation

Yang, Qinbo; Jia, Chenglin; Wang, Peiwei; Xiong, Minqi; Cui, Jingang; Li, Li; Wang, Wenjian; Wu, Qingyu; Yu, Chen; Zhang, Teng

doi:10.1016/j.ijcard.2014.09.204

Cited by 82 publications

(62 citation statements)

References 20 publications

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“…Mir-503 is transcribed with mir-424 due to their close proximity, and mir-503 has also been shown to be anti-angiogenic by targeting VEGFA [61–63]. Mir-505, which was increased in the hemangiosarcoma samples, has been shown to decrease endothelial cell migration and vascular tube formation [66]. One study found that mir-542-3p targeted angiopoietin-2 and acted as an anti-angiogenic signal [67].…”

Section: Discussionmentioning

confidence: 99%

A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs

et al. 2016

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BackgroundSplenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulation, and differential expression of miRNAs between normal and tumor tissue has been used to diagnose neoplastic diseases. The objective of this study was to determine differential expression of miRNAs by use of RNA-sequencing in canine spleens that were histologically confirmed as hemangiosarcoma, nodular hyperplasia, or normal.ResultsTwenty-two miRNAs were found to be differentially expressed in hemangiosarcoma samples (4 between hemangiosarcoma and both nodular hyperplasia and normal spleen and 18 between hemangiosarcoma and normal spleen only). In particular, mir-26a, mir-126, mir-139, mir-140, mir-150, mir-203, mir-424, mir-503, mir-505, mir-542, mir-30e, mir-33b, mir-365, mir-758, mir-22, and mir-452 are of interest in the pathogenesis of hemangiosarcoma.ConclusionsFindings of this study confirm the hypothesis that miRNA expression profiles are different between canine splenic hemangiosarcoma, nodular hyperplasia, and normal spleens. A large portion of the differentially expressed miRNAs have roles in angiogenesis, with an additional group of miRNAs being dysregulated in vascular disease processes. Two other miRNAs have been implicated in cancer pathways such as PTEN and cell cycle checkpoints. The finding of multiple miRNAs with roles in angiogenesis and vascular disease is important, as hemangiosarcoma is a tumor of endothelial cells, which are driven by angiogenic stimuli. This study shows that miRNA dysregulation is a potential player in the pathogenesis of canine splenic hemangiosarcoma.

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Section: Discussionmentioning

confidence: 99%

A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs

et al. 2016

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“…In zebrafish, miR-9 inhibits FGF signalling in the developing brain and does so by binding directly to the 3′UTR of Fgf8 mRNA (Leucht et al 2008). In human endothelial cells, hsamiR-505 inhibited FGF18 mRNA and protein levels and inhibited the activity of a luciferase reporter containing the 3′UTR of FGF18 (Yang et al 2014) suggesting that this microRNA interacts directly with FGF18 mRNA. Another miRNA that interacts with the 3′UTR of FGF18 is miR-195 (Wang et al 2017).…”

Section: Fgf8 Signalling and Micrornasmentioning

confidence: 99%

“…This may also hold for the theca cell layer, as expression has not, to our knowledge, been demonstrated in steroidogenic cells. It should also be noted that in human umbilical vein endothelial cell lines the expression of FGF18 is regulated by hsa-miR-505, as is the expression of high-mobility group box 1 (HMGB1) (Yang et al 2014), and HMGB1 has been implicated in preeclampsia (Nadeau-Vallée et al 2016). As FGF18 administration caused dilatation in the rat cerebral vasculature (Ellsworth et al 2003), it would be worth investigating if FGF18 plays a role in preeclampsia.…”

Section: Questions and Challengesmentioning

confidence: 99%

The fibroblast growth factor 8 family in the female reproductive tract

Estienne¹,

Price²

2018

Reproduction

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Several growth factor families have been shown to be involved in the function of the female reproductive tract. One subfamily of the fibroblast growth factor (FGF) superfamily, namely the FGF8 subfamily (including FGF17 and FGF18), has become important as Fgf8 has been described as an oocyte-derived factor essential for glycolysis in mouse cumulus cells and aberrant expression of FGF18 has been described in ovarian and endometrial cancers. In this review, we describe the pattern of expression of these factors in normal ovaries and uteri in rodents, ruminants and humans, as well as the expression of their receptors and intracellular negative feedback regulators. Expression of these molecules in gynaecological cancers is also reviewed. The role of FGF8 and FGF18 in ovarian and uterine function is described, and potential differences between rodents and ruminants have been highlighted especially with respect to FGF18 signalling within the ovarian follicle. Finally, we identify major questions about the reproductive biology of FGFs that remain to be answered, including (1) the physiological concentrations within the ovary and uterus, (2) which cell types within the endometrial stroma and theca layer express FGFs and (3) which receptors are activated by FGF8 subfamily members in reproductive tissues.Reproduction (2018) 155 R53-R62

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“…Interestingly, this TNF-α-induced up-regulation of miR-155 was attenuated by simvastatin through interfering mevalonate-geranylgeranyl-pyrophosphate-RhoA signaling pathway. Tumor suppressive miRNA, miR-505, targets FGF18, a proangiogenetic factor, and impairs the migration and tube formation of endothelial cells [97]. Aerobic exercise training (ET) may prevent microvascular abnormalities in hypertension.…”

Section: Introductionmentioning

confidence: 99%

Non-coding RNAs and Hypertension–Unveiling Unexpected Mechanisms of Hypertension by the Dark Matter of the Genome

Murakami¹

2015

CHYR

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Hypertension is a major risk factor of cardiovascular diseases and a most important health problem in developed countries. Investigations on pathophysiology of hypertension have been based on gene products from coding region that occupies only about 1% of total genome region. On the other hand, non-coding region that occupies almost 99% of human genome has been regarded as “junk” for a long time and went unnoticed until these days. But recently, it turned out that non-coding region is extensively transcribed to non-coding RNAs and has various functions. This review highlights recent updates on the significance of non-coding RNAs such as micro RNAs and long non-coding RNAs (lncRNAs) on the pathogenesis of hypertension, also providing an introduction to basic biology of non-coding RNAs. For example, microRNAs are associated with hypertension via neuro-fumoral factor, sympathetic nerve activity, ion transporters in kidneys, endothelial function, vascular smooth muscle phenotype transformation, or communication between cells. Although reports of lncRNAs on pathogenesis of hypertension are scarce at the moment, new lncRNAs in relation to hypertension are being discovered at a rapid pace owing to novel techniques such as microarray or next-generation sequencing. In the clinical settings, clinical use of non-coding RNAs in identifying cardiovascular risks or developing novel tools for treating hypertension such as molecular decoy or mimicks is promising, although improvement in chemical modification or drug delivery system is necessary.

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MicroRNA-505 identified from patients with essential hypertension impairs endothelial cell migration and tube formation

Cited by 82 publications

References 20 publications

A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs

A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs

The fibroblast growth factor 8 family in the female reproductive tract

Non-coding RNAs and Hypertension–Unveiling Unexpected Mechanisms of Hypertension by the Dark Matter of the Genome

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