MicroRNA-497-5p Suppresses Tumor Cell Growth of Osteosarcoma by Targeting ADP Ribosylation Factor-Like Protein 2

Sun, Zhibo; Li, Anjun; Yu, Zhihong; Li, Xiangwei; Guo, Xiao; Chen, Rong

doi:10.1089/cbr.2017.2268

Cited by 27 publications

(31 citation statements)

References 33 publications

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“…Previous studies have shown that miR‐497‐5p is of great interest in cancer therapies due to its association with various types of cancer (Chai et al, ; Chen et al, ; Sun et al, ). Here, we found that low miR‐497‐5p expression in HCC tissues was significantly correlated with poor prognosis of patients; thus, we focused on the roles and corresponding mechanisms of miR‐497‐5p in the progression of HCC.…”

Section: Introductionmentioning

confidence: 99%

Retracted: MiR‐497‐5p inhibits cell proliferation and metastasis in hepatocellular carcinoma by targeting insulin‐like growth factor 1

Huang

Brunicardi

et al. 2019

Molec Gen & Gen Med

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BackgroundMicroRNAs (miRNAs) play an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR‐497‐5p has been reported in various human malignancies. However, the role of miR‐497‐5p in hepatocellular carcinoma (HCC) remains unclear.ResultsIn this study, we found that miR‐497‐5p was downregulated in HCC tissues. The low level of miR‐497‐5p in HCC tumors was correlated with aggressive clinicopathological characteristics and predicted poor prognosis in HCC patients. The overexpression of miR‐497‐5p significantly inhibited HCC cell proliferation, colony formation, and metastasis in vitro and vivo. Bioinformatics analysis further identified insulin‐like growth factor 1 (IGF1) as a novel target of miR‐497‐5p in HCC cells.ConclusionOur study suggested that miR‐497‐5p regulates HCC cell survival, partially through downregulation of IGF1. Therefore, the miR‐497‐5p/IGF1 axis might serve as a novel therapeutic target in patients with HCC.

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Section: Introductionmentioning

confidence: 99%

Retracted: MiR‐497‐5p inhibits cell proliferation and metastasis in hepatocellular carcinoma by targeting insulin‐like growth factor 1

Huang

Brunicardi

et al. 2019

Molec Gen & Gen Med

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“…A recent study provides a novel solution to break the physiological and cellular barriers to deliver microRNAs [32]. Previous study show that miR-497-5p was significantly down-regulated in osteosarcoma and it suppresses tumour growth by targeting ADP ribosylation factor-like protein 2 [33]. Similarly, miR-497-5p was significantly down-regulated in glioma tissues and it targets SOX9 to inhibit proliferation, migration and invasion [34].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-497-5p down-regulation increases PD-L1 expression in clear cell renal cell carcinoma

Pan

et al. 2018

Journal of Drug Targeting

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Recent advances in immunotherapy are raising hope to treat clear cell renal cell carcinoma (ccRCC) with PD-L1 inhibitors, but only a small portion of patients are PD-L1 positive. The heterogeneous expression pattern of PD-L1 in patient population suggests that PD-L1 expression is under the control of diverse regulatory mechanisms. Although recent studies have identified numerous novel PD-L1 regulators, reports on microRNAs which modulate PD-L1 expression are much scarce. In this study, we confirmed that PD-L1 expression was up-regulated in ccRCC compared to paired normal tissues. Using miRDB and miRTarBase, 11 microRNAs were predicted to target PD-L1. After measuring the microRNA panel with TaqMan assays, we found that microRNA-497-5p down-regulation was associated with PD-L1 up-regulation. In TCGA-KIRC dataset, microRNA-497-5p down-regulation was also associated with PD-L1 up-regulation as well as shorter survival. We further validated that PD-L1 was a direct target of microRNA-497-5p in two RCC cell lines. In addition, microRNA-497-5p inhibited cell proliferation, clone formation and migration, while promoted apoptosis in in-vitro assays. Our study reveals a novel regulatory mechanism of PD-L1 expression and the potential of miR-497-5p as therapeutic target and biomarker deserves further investigation.

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“…miR-5590-3p suppresses the gastric tumorigenesis by negatively regulating DDX5/AKT/m-TOR pathway [5]. Recently, some studies have shown that miR-497-5p functions as a tumor suppressive miRNA in various cancers, including melanoma [6], osteosarcoma [7] and angiosarcoma [8]. The hTERT, ADP ribosylation factor-like protein 2 and KCa3.1 are potential target of miR-497-5p in these cancers.…”

Section: Introductionmentioning

confidence: 99%

miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3

et al. 2019

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MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated with the disease stage. Inhibition of miR-497-5p promoted GC cell proliferation and growth. By contrast, miR-497-5p ectopic expression suppressed the proliferation and growth of GC cells. In addition, miR-497-5p inhibited DNA synthesis and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC cells. Our study revealed that miR-497-5p inhibited GC cell proliferation and growth via targeting PDK3.

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MicroRNA-497-5p Suppresses Tumor Cell Growth of Osteosarcoma by Targeting ADP Ribosylation Factor-Like Protein 2

Abstract: Taken together, our findings revealed miR-497-5p may be a tumor suppressor in OS and serve as a promising therapeutic target for OS.

Cited by 27 publications

References 33 publications

Retracted: MiR‐497‐5p inhibits cell proliferation and metastasis in hepatocellular carcinoma by targeting insulin‐like growth factor 1

Retracted: MiR‐497‐5p inhibits cell proliferation and metastasis in hepatocellular carcinoma by targeting insulin‐like growth factor 1

MicroRNA-497-5p down-regulation increases PD-L1 expression in clear cell renal cell carcinoma

miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3

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