MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2)

Xu, Yuqiang; Ge, Kuikui; Lu, Ji; Huang, Jinjiang; Wei, Wei; Huang, Qingshan

doi:10.1016/j.biopha.2017.06.047

Cited by 20 publications

(22 citation statements)

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“…Upregulation of eca‐miR‐493b and eca‐miR‐541 was associated with advanced tumour stage (ESA) in ES tumours and might therefore also be of prognostic significance. Interestingly, these miRNAs possess rather tumour‐suppressive functions in diverse human cancers where they are often downregulated . If upregulation of eca‐miR‐493b and eca‐miR‐541 drives oncogenesis in ES and whether inhibition of these two miRNAs could possibly stop ES disease progression, needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

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Differentially expressed microRNAs, including a large microRNA cluster on chromosome 24, are associated with equine sarcoid and squamous cell carcinoma

Bogedale

Jagannathan

Gerber

et al. 2019

Vet Comparative Oncology

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The aim of this study was to investigate microRNA (miRNA) differential expression in the two most common equine skin tumours, equine sarcoid (ES) and squamous cell carcinoma (SCC), and its potential influence on the tumour microenvironment at post‐transcriptional level. We investigated miRNA fingerprints in four subgroups: mild (ESM) and aggressive (ESA) ES and ocular SCC (oSCC) and genital SCC (gSCC). Three tumours and three control samples were included in each of the four subgroups. Following next generation sequencing, miRNA differential expression analysis using DESeq2 was carried out. Pathways associated with the human mature homologues of identified dysregulated miRNAs were predicted using DIANA‐ miRPath v3.0. When comparing tumour vs control tissue, 57 miRNAs in ESM, six in ESA, 47 in oSCC and zero in gSCC were found to be differentially expressed and may thus serve as potential diagnostic tissue biomarkers. Whereas, ES lesions in general were associated with downregulation of the miR‐200 family, which may trigger epithelial‐mesenchymal transition, ESM lesions were associated with upregulation of the proposed tumour‐suppressive miRNA cluster on equine chromosome 24. In contrast, the oSCC tumours showed downregulation of this cluster as well as downregulation of the miR‐34 family, which may favour oSCC tumour cell metabolism. To further validate the proposed diagnostic miRNA fingerprints and their suggested biological effects, further miRNA studies need to be carried out in larger study cohorts.

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Section: Discussionmentioning

confidence: 99%

“…Interestingly, these miRNAs possess rather tumour-suppressive functions in diverse human cancers where they are often downregulated. [47][48][49][50][51][52] If upregulation of eca-miR-493b…”

Section: Pathway Analysismentioning

confidence: 99%

Differentially expressed microRNAs, including a large microRNA cluster on chromosome 24, are associated with equine sarcoid and squamous cell carcinoma

Bogedale

Jagannathan

Gerber

et al. 2019

Vet Comparative Oncology

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“…5A). Moreover, we screened literatures relevant to miR-493-3p targeted genes in the PubMed, and indenti ed 13 target genes of miR-493-3P including: AKT2, STK38L, HMGA2, E2F5, ETS1, FAM168A, PHLPP2, RSPO2, SP1, ANTXR1, STMN-1, KCNH2, ZFX [19][20][21][26][27][28][29][30]. Ultimately, a total of 46 potential target genes of miR-493-3p were identi ed for further analysis.…”

Section: Resultsmentioning

confidence: 99%

Identification of the Expression Signature and Potential Mechanisms of miR-493-3p in NSCLC using Bioinformatics Strategy: A Comprehensive Study from TCGA and GEO Datasets

zou

Zou

Luo

et al. 2020

Preprint

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Abstract Background Recent evidence highlights that miR-493-3p serve as crucial regulators of tumorigenesis. Nevertheless, the expression and clinical roles of miR-493-3p has been rarely reported in non-small cell lung cancer (NSCLC). Thus, this study was aim to investigate the expression status and potential mechanism of miR-493-3p in NSCLC progression. Methods We initially examined the expression of miR-493-3p in NSCLC through The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) microarrays. The overlap of the conjecture miR-493-3p target genes and down-regulated genes in NSCLC from TCGA were identified as the possible miR-493-3p target genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses and protein-protein interaction (PPI) network were constructed to explore the biological function and hub genes of miR-493-3p targets. The expression pattern and prognosis value of key hub genes were examined by Genotype-Tissue Expression (GTEx) database, The Human Protein Atlas and Kaplan- Meier Plotter database. Results miR-493-3p was significantly increased in NSCLC tissues and connected with tumor stage in TCGA and GEO database. A total of 46 genes were identified as miR-493-3p targets, and those involved in various key pathways by GO and KEGG analysis. Furthermore, PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) was indicated of miR-493-3p key targets, which low-expressed in NSCLC and predicted better overall survival. Conclusions Our study emphasized that up-regulated miR-493-3p may target PHLLP2 and predicate worse prognosis of NSCLC patients.

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“…Previous studies have causally linked individual microRNA expression changes to adverse biologic processes in HCC, including rapid proliferation, epithelial‐to‐mesenchymal transition (EMT), local tissue invasion, and vascular invasion . A summary of recently published studies with purported miRNA mechanisms is provided in Table . For the majority of cases, miRNA loss correlates to induction of a target oncogene, and miRNA gain correlates to repression of a target tumor suppressor.…”

Section: Microrna Hcc Subtypingmentioning

confidence: 99%

Molecular signatures in hepatocellular carcinoma: A step toward rationally designed cancer therapy

Erstad

Fuchs

Tanabe

2018

Cancer

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Molecular characterization of hepatocellular carcinoma (HCC) has greatly improved our understanding of disease pathogenesis. Mutational analysis, RNA and microRNA expression profiling, and epigenetic characterization have revealed common aberrations in oncogenes and tumor suppressors that correlate with disease biology and serve as a guide for the rational design of targeted therapies. These approaches have also led to the discovery of novel targets, including mutations in isocitrate dehydrogenase and chromatin remodeling enzymes. With the advent of immunotherapy, RNA expression profiling of the tumor microenvironment has identified a subset of HCC with high lymphocyte infiltration that may benefit from checkpoint inhibitor therapy. Molecular signatures thus capture the biology of a tumor, providing a supplement to current staging schema, which are based on tumor size and number, for more accurate prognostication of recurrence risk and survival. Molecular signatures may also be used to guide interventional therapy by defining those most suitable for transplantation or locoregional therapy rather than surgical resection. Finally, a multiomics approach involves the aggregation and analysis of multiple signatures for a more comprehensive characterization of pathogenic mechanisms. This broader approach attempts to address issues with signaling pathway cross-talk and redundancy, which have greatly limited the potential value of targeted therapies to date. Cancer 2018. © 2018 American Cancer Society.

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MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2)

Cited by 20 publications

References 50 publications

Differentially expressed microRNAs, including a large microRNA cluster on chromosome 24, are associated with equine sarcoid and squamous cell carcinoma

Differentially expressed microRNAs, including a large microRNA cluster on chromosome 24, are associated with equine sarcoid and squamous cell carcinoma

Identification of the Expression Signature and Potential Mechanisms of miR-493-3p in NSCLC using Bioinformatics Strategy: A Comprehensive Study from TCGA and GEO Datasets

Molecular signatures in hepatocellular carcinoma: A step toward rationally designed cancer therapy

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