MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases

Sequencing Reveals miRNAs Enriched in the Developing Mouse Enteric Nervous System

“…We found that miR-9 and miR-124 both had well-established roles in central nervous system biology [ 20 , 21 , 22 , 23 ] and were capable of directly transforming fibroblasts into neuronal progenitors [ 24 , 25 ]. Meanwhile, miR-27b is frequently studied in the context of the heart [ 26 , 27 ], and miR-488 is suggested to be associated with many disease and cancer states [ 28 ], but neither seemed closely tied to neuronal development. We decided to pursue further analyses of miR-137, as multiple reports suggest that miR-137 is involved in hippocampal neuronal development, though with differing indications for its specific role [ 29 , 30 , 31 ].…”

“…miR-488 is usually (but not always) downregulated in cancer, acute myocardial infarction, and other conditions [ 28 ]. In the brain, miR-488 plays an anti-apoptotic role and can limit neuronal apoptosis in epilepsy or ischemic stroke [ 48 , 49 ].…”

“…While miR-124 has been studied in HSCR, both miR-124 and its proposed target gene SOX9 were upregulated in the stenotic bowel compared to the normal bowel from the same patient [47], indicating further research is required. miR-488 is usually (but not always) downregulated in cancer, acute myocardial infarction, and other conditions [28]. In the brain, miR-488 plays an anti-apoptotic role and can limit neuronal apoptosis in epilepsy or ischemic stroke [48,49].…”