MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase

Chai, Jie; Wang, Shan; Han, Dan; Wang, Dong; Xie, Chao; Guo, Hongbo

doi:10.1007/s13277-014-2766-3

Cited by 64 publications

(56 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prognosis of CRC largely results from the presence of distal metastases or not, since in situ cancer and cancer with invasion of lymph nodes are both highly treatable [1][2][3]. However, distal metastases of CRC to the liver, lungs, or other organs cause difficulties for treatments, leading to poor therapeutic outcome [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

MiR-200 suppresses metastases of colorectal cancer through ZEB1

et al. 2015

View full text Add to dashboard Cite

Poor prognosis of some colorectal cancer (CRC) cases largely results from early metastases of CRC to the distal organs. Thus, suppression of the invasion of CRC appears to be crucial therapy. Since microRNAs (miRNAs) play critical roles in the regulation of cancer metastases, identification of the involved miRNAs may provide novel therapeutic targets for CRC treatment. Here, we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients, compared to the paired non-tumor tissue. Moreover, the levels of miR-200 and ZEB1 are inversely correlated. Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation, which was confirmed by luciferase reporter assay. Moreover, miR-200 overexpression inhibited ZEB1-mediated cell invasiveness, while miR-200 depletion increased ZEB1-mediated cell invasiveness in CRC cells. Together, our data suggest that miR-200 suppression in CRC cells may promote ZEB1-mediated cancer metastasis. Our work thus highlights a novel molecular regulatory machinery that regulates metastases of CRC.

show abstract

Section: Introductionmentioning

confidence: 99%

MiR-200 suppresses metastases of colorectal cancer through ZEB1

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Recently, increasing evidences indicated that microRNAs (miRNAs), non-coding small RNAs, act as oncogenes or tumor suppressors in the development of cancer [6][7][8]. MiRNAs play important roles in biological progression of many types of human tumors by regulating gene expression through binding to 3′-UTR of the target mRNA [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression

Long

Xia

et al. 2015

Tumor Biol.

View full text Add to dashboard Cite

Breast cancer is one of the most common malignancies and a major cause of cancer-related mortality all over the world. A growing body of reports revealed that microRNAs play essential roles in the progression of cancers. Aberrant expression of miR-503 has been reported in several kinds of cancer. The aim of the current study was to elucidate the role of miR-503 in the pathogenesis of breast cancer. In the present study, our results suggested that miR-503 expression was markedly downregulated in breast cancer tissues and cells. Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1. Together, our findings provide new knowledge regarding the role of miR-503 in the progression of breast cancer and indicate the role of miR-503 as a tumor suppressor microRNA (miRNA) in breast cancer.

show abstract

“…Previous studies have demonstrated that miR-455 is deregulated in multiple human diseases, and contributes to multiple physiological and pathological processes including glioblastoma, steroidogenesis, colorectal cancer, chondrogenesis and osteoarthritis (29)(30)(31)(32)(33). Chai et al (33) reported that expression levels of miR-455 were decreased in colorectal tissues, and overexpression of miR-455 inhibited growth and invasion of colorectal cells.…”

Section: Discussionmentioning

confidence: 99%

“…Chai et al (33) reported that expression levels of miR-455 were decreased in colorectal tissues, and overexpression of miR-455 inhibited growth and invasion of colorectal cells. Using TargetScan, luciferase report assay, RT-qPCR and western blot, RAF1 was validated as a direct target gene of miR-455 in colorectal cancer (33). These findings suggested that miR-455/RAF1 may represent a new potential therapeutic target for colorectal cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Expression levels of microRNA-455 and its potential functions by targeting IGF-1R in melanoma

Wang

Shan

2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. Melanoma has the highest fatality and malignancy of all skin cancers. In cancer, microRNAs (miRNAs) act as tumor suppressors or oncogenes, and inactivation of oncogenic miRNAs or restoration of tumor suppressor miRNAs has potential for cancer treatment. In the present study, miR-455 expression levels were examined in melanoma tissues and cell lines, and miR-455 was significantly downregulated in melanoma compared with matched normal tissues or normal epidermal melanocytes. In addition, increasing miR-455 expression in melanoma cells reduced cell proliferation and invasion. Bioinformatic analysis revealed that insulin-like growth factor 1 receptor (IGF-1R) was a putative target of miR-455. Luciferase reporter assays, reverse transcription-quantitative polymerase chain reaction and western blot confirmed that miR-455 targeted the 3'-untranslated region of IGF-1R and thus regulated the biological processes of melanoma cells. IGF-1R knockdown resulted in similar effects as miR-455 overexpression in melanoma cells. In summary, these findings indicated that miR-455 was downregulated in melanoma, and inhibited proliferation and invasion of melanoma cells through directly targeting IGF-1R. This also suggested that the restoration of miR-455 may be worth investigation as a therapeutic treatment for patients with melanoma.

show abstract

MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase

Cited by 64 publications

References 37 publications

MiR-200 suppresses metastases of colorectal cancer through ZEB1

MiR-200 suppresses metastases of colorectal cancer through ZEB1

MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression

Expression levels of microRNA-455 and its potential functions by targeting IGF-1R in melanoma

Contact Info

Product

Resources

About