2014
DOI: 10.1007/s13277-014-2766-3
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MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase

Abstract: Colorectal cancer (CRC, also known as colon cancer, rectal cancer, or bowel cancer) is the second leading cause of cancer mortality in the Western world. MicroRNAs (miRNAs) are a class of small (18-25 nucleotides long) noncoding RNAs with important posttranscriptional regulatory functions. miRNAs play important roles in various physiological and pathological processes including carcinogenesis in various solid cancers including CRC. In order to investigate the roles that miRNAs played in CRC, the expression of … Show more

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Cited by 64 publications
(56 citation statements)
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“…The prognosis of CRC largely results from the presence of distal metastases or not, since in situ cancer and cancer with invasion of lymph nodes are both highly treatable [1][2][3]. However, distal metastases of CRC to the liver, lungs, or other organs cause difficulties for treatments, leading to poor therapeutic outcome [4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…The prognosis of CRC largely results from the presence of distal metastases or not, since in situ cancer and cancer with invasion of lymph nodes are both highly treatable [1][2][3]. However, distal metastases of CRC to the liver, lungs, or other organs cause difficulties for treatments, leading to poor therapeutic outcome [4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, increasing evidences indicated that microRNAs (miRNAs), non-coding small RNAs, act as oncogenes or tumor suppressors in the development of cancer [6][7][8]. MiRNAs play important roles in biological progression of many types of human tumors by regulating gene expression through binding to 3′-UTR of the target mRNA [9][10][11].…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies have demonstrated that miR-455 is deregulated in multiple human diseases, and contributes to multiple physiological and pathological processes including glioblastoma, steroidogenesis, colorectal cancer, chondrogenesis and osteoarthritis (29)(30)(31)(32)(33). Chai et al (33) reported that expression levels of miR-455 were decreased in colorectal tissues, and overexpression of miR-455 inhibited growth and invasion of colorectal cells.…”
Section: Discussionmentioning
confidence: 99%
“…Chai et al (33) reported that expression levels of miR-455 were decreased in colorectal tissues, and overexpression of miR-455 inhibited growth and invasion of colorectal cells. Using TargetScan, luciferase report assay, RT-qPCR and western blot, RAF1 was validated as a direct target gene of miR-455 in colorectal cancer (33). These findings suggested that miR-455/RAF1 may represent a new potential therapeutic target for colorectal cancer treatment.…”
Section: Discussionmentioning
confidence: 99%