MicroRNA-4287 alleviates inflammatory response <i>via</i> targeting RIPK1 in osteoarthritis

Xia, Mingyang; Wu, Yixiong; Feng, Xiaoguang

doi:10.1080/08916934.2022.2067986

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…The prediction software of miRNA-targeting genes showed potential genes in interest. In previous literature, hsa-miR-1323 widely regulate cancer progression and radiotherapy effects 58 , miR-711 regulates NCI-N87 and SNU-1 cells gastric cancer lines progression by targeting CD44 59 , miR-4287 is a critical molecule in osteoarthritis development 60 , miR-650 inhibits the progression of glioma by targeting FAM83F 61 . The miR-532-5p is reported to promote cancer proliferation and migration by targeting the RERG gene (RAS like estrogen-regulated growth inhibitor) and the EGFR (epidermal growth factor receptor) gene 62 .…”

Section: Discussionmentioning

confidence: 99%

Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway

Xuan¹,

Wu²,

Wang³

et al. 2023

Int. J. Med. Sci.

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Although adjuvant tamoxifen therapy is beneficial to estrogen receptor-positive (ER + ) breast cancer patients, a significant number of patients still develop metastasis or undergo recurrence. Therefore, identifying novel diagnostic and prognostic biomarkers for these patients is urgently needed. Predictive markers and therapeutic strategies for tamoxifen-resistant ER + breast cancer are not clear, and micro (mi)RNAs have recently become a focal research point in cancer studies owing to their regulation of gene expressions, metabolism, and many other physiological processes. Therefore, systematic investigation is required to understand the modulation of gene expression in tamoxifen-resistant patients. High-throughput technology uses a holistic approach to observe differences among expression profiles of thousands of genes, which provides a comprehensive level to extensively investigate functional genomics and biological processes. Through a bioinformatics analysis, we revealed that glutamine synthetase/glutamate-ammonia ligase (GLUL) might play essential roles in the recurrence of tamoxifen-resistant ER + patients. GLUL increases intracellular glutamine usage via glutaminolysis, and further active metabolism-related downstream molecules in cancer cell. However, how GLUL regulates the tumor microenvironment for tamoxifen-resistant ER + breast cancer remains unexplored. Analysis of MetaCore pathway database demonstrated that GLUL is involved in the cell cycle, immune response, interleukin (IL)-4-induced regulators of cell growth, differentiation, and metabolism-related pathways. Experimental data also confirmed that the knockdown of GLUL in breast cancer cell lines decreased cell proliferation and influenced expressions of specific downstream molecules. Through a Connectivity Map (CMap) analysis, we revealed that certain drugs/molecules, including omeprazole, methacholine chloride, ioversol, fulvestrant, difenidol, cycloserine, and MK-801, may serve as potential treatments for tamoxifen-resistant breast cancer patients. These drugs may be tested in combination with current therapies in tamoxifen-resistant breast cancer patients. Collectively, our study demonstrated the crucial roles of GLUL, which provide new targets for the treatment of tamoxifen-resistant breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway

Xuan¹,

Wu²,

Wang³

et al. 2023

Int. J. Med. Sci.

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“…Inhibiting RIPK1 can effectively curb the progression of joint inflammation. 47 RIPK1 is an important administrator in the TNFα/TNFR1-NF-κB signalling. TNFα activates the cascade involving NF-κB or terminal MAPK, extracellular signal-regulated kinase (ERK) and Jun N-terminal kinase (JNK).…”

Section: Discussionmentioning

confidence: 99%

“…Inhibiting RIPK1 can effectively curb the progression of joint inflammation 47 . It has been shown that the level of TNF‐α‐induced inflammatory mediators falls in human TMJ synoviocytes treated with Nec‐1.…”

Section: Discussionmentioning

confidence: 99%

“…Inhibiting RIPK1 can effectively curb the progression of joint inflammation. 47 It has been shown that the level of TNF‐α‐induced inflammatory mediators falls in human TMJ synoviocytes treated with Nec‐1. Consistently, our results showed that TNF‐α and CHX‐derived CM (TC‐CM) elevated the expression of inflammatory factors (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Alleviation of temporomandibular joint osteoarthritis by targeting RIPK1‐mediated inflammatory signalling

Cao,

Peng,

Yan

et al. 2023

J Cellular Molecular Medi

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Temporomandibular joint osteoarthritis (TMJOA), prevalent in adolescents and the elderly, has serious physical and psychological consequences. TMJOA is a degenerative disease of the cartilage and bone, mostly driven by inflammation, and synoviocytes are the first and most important inflammatory factor releasers. Receptor‐interacting serine/threonine‐protein kinase (RIPK1) promotes inflammatory response and cell death during an array of illnesses. This research aimed to explore the impacts of RIPK1 inhibitor therapy in TMJOA and the mechanism of RIPK1 in inducing inflammation during TMJOA. Herein, inhibition of RIPK1 suppressed the elevated levels of inflammatory factors, nuclear factor kappa B (NF‐κB), along with markers of apoptosis and necroptosis after tumour necrosis factor (TNF)‐α/cycloheximide (CHX) treatment in synoviocytes. Moreover, inflammation models were constructed in vivo through complete Freund's adjuvant (CFA) induction and disc perforation, and the findings supported that RIPK1 inhibition protected TMJ articular cartilage against progressive degradation. RIPK1 regulates NF‐κB activation via cellular inhibitor of apoptosis proteins (cIAP), apoptosis via caspase‐8, and necroptosis via RIPK3/mixed lineage kinase domain‐like (MLKL) in synoviocytes, which in turn facilitates TMJOA inflammation progression.

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Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137

Zheng,

Yang,

Chen

et al. 2023

Autoimmunity

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MicroRNA-4287 alleviates inflammatory response via targeting RIPK1 in osteoarthritis

Cited by 3 publications

References 28 publications

Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway

Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway

Alleviation of temporomandibular joint osteoarthritis by targeting RIPK1‐mediated inflammatory signalling

Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137

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