microRNA -378a-3p Restrains the Proliferation of Retinoblastoma Cells but Promotes Apoptosis of Retinoblastoma Cells via Inhibition of FOXG1

Zhang, Chao

doi:10.1167/iovs.61.5.31

Cited by 14 publications

(8 citation statements)

References 42 publications

(46 reference statements)

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“… 39 In contrast, it acted as an tumor suppressor in gastric cancer, 40 colorectal cancer, 41 liver cancer, 42 glioblastoma, 43 prostate cancer, 44 breast cancer (BC), 45 medulloblastoma (MB), 46 pituitary adenoma (PA), 47 oral squamous cell carcinomas, 48 bladder cancer, 49 esophageal carcinoma, 50 rhabdomyosarcoma (RMS), 51 and retinoblastoma (RB). 52 Compared with normal tissues and no lymph node metastasis cancer tissues, miR-378a was upregulated in cervical cancer tissues, especially in CIN III and lymph node metastasis cervical cancer. 33 Additionally, a study of 120 cholangiocarcinoma tissues and adjacent noncancerous tissues found that miR-378a expression increased with the development of the TNM (T-tumor, N-nodes, M-metastasis) stages.…”

Section: Introductionmentioning

confidence: 94%

Depicting the Implication of miR-378a in Cancers

Qin

Liang

et al. 2022

Technol Cancer Res Treat

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MicroRNA-378a (miR-378a), including miR-378a-3p and miR-378a-5p, are encoded in PPARGC1B gene. miR-378a is essential for tumorigenesis and is an independent prognostic biomarker for various malignant tumors. Aberrant expression of miR-378a affects several physiological and pathological processes, including proliferation, apoptosis, tumorigenesis, cancer invasion, metastasis, and therapeutic resistance. Interestingly, miR-378a has a dual functional role in either promoting or inhibiting tumorigenesis, independent of the cancer type. In this review, we comprehensively summarized the role and regulatory mechanisms of miR-378a in cancer development, hoping to provide a direction for its potential use in cancer therapy.

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Section: Introductionmentioning

confidence: 94%

Depicting the Implication of miR-378a in Cancers

Qin

Liang

et al. 2022

Technol Cancer Res Treat

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“…Previous studies have shown that miR-378a-3p is a critical tumor suppressor in multiple cancers, including hepatocellular carcinoma 32 , glioma 33 , and retinoblastoma 34 . However, the function and mechanism of miR-378a-3p in GC have not been thoroughly explored.…”

Section: Resultsmentioning

confidence: 99%

“…MiR-378a-3p, a small noncoding RNA originating from chromosome 5q32, is 22 nt in length. Most studies have reported that miR-378a-3p acts as a tumor suppressor in diverse types of cancers, such as hepatocellular carcinoma 32 , colorectal cancer 45 , esophageal squamous cell carcinoma 46 , ovarian cancer 47 , cervical cancer 48 , retinoblastoma 34 , papillary thyroid cancer 49 , breast cancer 50 , prostate cancer 51 , and glioblastoma 52 . However, miR-378a-3p has also been reported to promote the progression of Burkitt lymphoma 53 .…”

Section: Discussionmentioning

confidence: 99%

MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2

Liu

et al. 2022

Cancer Biol Med

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Objective: To improve the prognosis of patients with gastric cancer (GC), more effective therapeutic targets are urgently needed. Increasing evidence indicates that miRNAs are involved in the progression of various tumors, and RAS-associated protein in the brain 31 (RAB31) is upregulated and promotes the progression of multiple malignant tumors. Here, we focused on identifying RAB31-targeted miRNAs and elucidating their potential mechanism in the progression of GC. Methods: RAB31 and miR-378a-3p expression levels were detected in paired fresh GC tissues and GC cell lines. Bioinformatics analysis was used to predict the miRNAs targeting RAB31 and the relationships between RAB31 and other genes. Dual-luciferase reporter assays were applied to verify the targeted interaction relationship. CCK-8, colony formation, flow cytometry, wound healing, and Transwell assays were performed to assess the proliferation, apoptosis, migration, and invasion of GC cells. Tumorsphere formation assays were performed to assess the stemness of gastric cancer stem cells. Related proteins were detected by Western blot. Xenograft assays in nude mice were performed to explore the effect of miR-378a-3p in vivo. Results: We report the first evidence that miR-378a-3p is downregulated in GC, whereas its overexpression inhibits proliferation, invasion, and migration as well as promotes apoptosis in GC cells. Mechanistically, miR-378a-3p inhibits the progression of GC by directly targeting RAB31. Restoring RAB31 expression partially offsets the inhibitory effect of miR-378a-3p. Further research revealed that miR-378a-3p inhibits GLI1/2 in the Hedgehog signaling pathway and attenuates the stemness of gastric cancer stem cells. Finally, xenograft assays showed that miR-378a-3p inhibits GC tumorigenesis in vivo. Conclusions: MiR-378a-3p inhibits GC progression by directly targeting RAB31 and inhibiting the Hedgehog signaling pathway proteins GLI1/2.

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“…To date, the role of miR-378a-3p in cell apoptosis remains unclear. Two studies have found that miR-378a-3p promotes the apoptosis of ovarian cancer cells and retinoblastoma cells [ 17 , 23 ]. However, one study demonstrated that miR-378a-3p prevents H9C2 cardiomyocyte cells apoptosis during ischemic injury [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

LncRNA136131 suppresses apoptosis of renal tubular epithelial cells in acute kidney injury by targeting the miR-378a-3p/Rab10 axis

Pan

Yang

et al. 2022

Aging

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The pathogenesis of acute kidney injury (AKI) is not fully understood. To date, the exact role and regulatory mechanism of long non-coding RNA (lncRNA)136131 in AKI remains unclear. Here, we demonstrate that lncRNA136131 in BUMPT cells is induced by antimycin A. Furthermore, after incubating BUMPT cells in antimycin for two hours, lncRNA136131 prevented BUMPT cell apoptosis and cleaved caspase-3 expression. Mechanistically, lncRNA136131 sponged miR-378a-3p and then increased the expression of Rab10 to suppress apoptosis. Finally, I/R-induced decline of renal function, tubular damage, renal tubular cells apoptosis, and the upregulation of cleaved caspase-3 were aggravated by lncRNA136131 siRNA. In contrast, this effect was attenuated by the overexpression of lncRNA136131. In conclusion, lncRNA136131 protected against I/R-induced AKI progression by targeting miR-378a-3p/Rab10 and may be utilized as a novel target for AKI therapeutics.

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microRNA -378a-3p Restrains the Proliferation of Retinoblastoma Cells but Promotes Apoptosis of Retinoblastoma Cells via Inhibition of FOXG1

Abstract: 378a-3p restrains the proliferation of retinoblastoma cells but promotes apoptosis of retinoblastoma cells via inhibition of FOXG1.

Cited by 14 publications

References 42 publications

Depicting the Implication of miR-378a in Cancers

Depicting the Implication of miR-378a in Cancers

MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2

LncRNA136131 suppresses apoptosis of renal tubular epithelial cells in acute kidney injury by targeting the miR-378a-3p/Rab10 axis

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