MicroRNA‑337‑3p impedes breast cancer progression by targeting cyclin‑dependent kinase 1

Kong, Shuxin; Liu, Jianyang; Zhang, Bin; Lv, Feng; Yu, Yang; Qin, Tao

doi:10.3892/ol.2021.13133

Cited by 4 publications

(2 citation statements)

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“…Breast cancer (BC) is the commonest cancer of women (30%) globally. BC is one of the most important leading causes of death ( 1 – 3 ). American Cancer Society Statistics (ACSS) shows that the number of new invasive breast cancer cases and its death was 252,710 and 40,610 in 2017, respectively ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…American Cancer Society Statistics (ACSS) shows that the number of new invasive breast cancer cases and its death was 252,710 and 40,610 in 2017, respectively ( 1 ). ACSS reported that since the early of 2019 more than 3.8 million women were diagnosed with BC and more than 150,000 of their disease were metastatic type ( 3 , 4 ). Triple-negative BC cells are introduced by the lack of estrogenic receptors such as ERα/PR/HER2 in about 10–20% of all breast cancers ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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In vivo assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

et al. 2022

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Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice. The human breast cancer MDA-MB-231 cells were subcutaneously transplanted into the supra-femoral right side of female Balb/c-nude mice. The dual shRNA vector harboring G1 cyclins shRNAs (bipSUR) was intratumorally injected by the in vivo jetPEI transfection reagent for 2 weeks. We have evaluated tumor growth and tumor weight as parameters of tumor progression. Finally, necropsy, histopathological analysis, and immunodetection of G1 cyclins were assessed. Also, apoptosis induction in tumor tissues was evaluated by TUNEL assay. No toxicity and metastasis was observed in the tumor-bearing mice treated by the bipSUR. Tumor weight and volume were significantly lower in the bipSUR treated mice than untreated tumor-bearing mice and control. Histopathological observations revealed more apoptotic foci and lower mitotic cells in tumor sections in the treated mice than in control groups. A significant reduction of G1 cyclins at the protein level was indicated in the bipSUR treated mice than in other groups. Apoptosis in tumor tissues was remarkably induced in response to the bipSUR (42.53%). The bipSUR reduced the protein expression of G1 cyclins and exhibited an inhibitory effect on MDA-MB-231 xenograft mice through apoptosis induction. Further research is demanded to identify the protein partners of G1 cyclins involved in the cancer pathways. These may offer new insight into the biomedical function of G1 cyclins in breast cancer progression.

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Section: Introductionmentioning

confidence: 99%