MicroRNA-320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor-1α

Liang, Yong; Chen, Xi; Zhu, Liang

doi:10.3892/etm.2017.4779

Cited by 27 publications

(14 citation statements)

References 38 publications

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“…Among the five previously identified ARGs associated with MM, HIF1A is the most widely studied (59,60). Hypoxia, a central characteristic for cancer incidence and progression, occurs when most types of cancer are evolving (59)(60)(61)(62)(63)(64). HIF1A is a hypoxia-inducible factor, and constitutive expression of HIF1A in MM indicates that suppression of HIF1A-mediated transcription could become a favorable target for MM (65)(66)(67)(68).…”

Section: Discussionmentioning

confidence: 99%

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

Zhu¹,

Wang

Zeng³

et al. 2019

Oncol Lett

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Autophagy has an important role in the pathogenesis of plasma cell development and multiple myeloma (MM); however, the prognostic role of autophagy-related genes (ARGs) in MM remains undefined. In the present study, the expression profiles of 234 ARGs were obtained from a Gene Expression Omnibus dataset (accession GSE24080), which contains 559 samples of patients with MM analyzed with 54,675 probes. Univariate Cox regression analysis identified 55 ARGs that were significantly associated with event-free survival of MM. Furthermore, a risk score with 16 survival-associated ARGs was developed using multivariate Cox regression analysis, including ATIC,

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Section: Discussionmentioning

confidence: 99%

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

Zhu¹,

Wang

Zeng³

et al. 2019

Oncol Lett

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“…miRNAs may act as tumour suppressors or oncogenes, in which aberrantly downregulated miRNAs play tumour-suppressive roles, whereas highly expressed miRNAs serve oncogenic roles in carcinogenesis and cancer progression (12). Emerging studies have indicated that numerous miRNAs are dysregulated in RB, such as miR-29a (13), miR-320 (14), miR-613 (15) and miR-143 (16). Aberrantly expressed miRNAs are closely related with RB formation and progression by regulating various pathological behaviours, such as cellular proliferation, apoptosis, invasion, metastasis and angiogenesis (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

You

2018

Oncol Rep

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Accumulated studies have highlighted that the dysregulation of microRNAs (miRNAs) in retinoblastoma (RB) is a leading cause for tumourigenesis and tumour development. Therefore, the elucidation of the expression, functional roles and underlying mechanisms of miRNAs in RB will help the development of promising therapeutic methods to improve the prognosis of RB patients. The aim of this study was to detect miRNA‑758 (miR‑758) expression in RB tissues and cell lines, and to determine the effects and underlying mechanisms of miR‑758 on RB progression. The results demonstrated that miR‑758 was downregulated in both RB tissues and cell lines. In vitro functional experiments revealed that upregulation of miR‑758 inhibited cell proliferation, migration and invasion, and induced apoptosis in RB. In addition, paired box protein 6 (PAX6) was a direct target gene of miR‑758 in RB. Furthermore, PAX6 was upregulated in RB tissues, and this upregulation was inversely associated with the expression level of miR‑758. In addition, PAX6 reintroduction abrogated the tumour‑suppressive effects of miR‑758 overexpression on RB cell proliferation, migration, invasion and apoptosis. Furthermore, miR‑758 overexpression inactivated the PI3K/Akt pathway in RB cells by inhibiting PAX6. In conclusion, our current study provided sufficient evidence to demonstrate that miR‑758 inhibits the progression of RB by directly targeting PAX6 and regulating the PI3K/Akt pathway, thereby suggesting that this miRNA may be developed as a therapeutic target for treating patients with RB.

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“…The role of adequate SIRT1 levels for proper liver function is well documented, as SIRT1 deletion results in hepatic steatosis and inflammation, and SIRT1 activators improve hepatosteatosis and insulin resistance [80,81]. MicroRNA-320 may also regulate the development of autophagy by targeting hypoxia-inducible factor-1α (HIF-1α) and mTOR under hypoxic conditions [82]. Dysregulation of the mTOR pathway-a key controller of lipid metabolism, regulating lipogenesis in the liver, lipolysis in white adipose tissue, and adipogenesis-may promote liver steatosis and development of NAFLD [83].…”

Section: Discussionmentioning

confidence: 99%

Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis

et al. 2020

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Nutrient excess enhances glucose-dependent insulinotropic polypeptide (GIP) secretion, which may in turn contribute to the development of liver steatosis. We hypothesized that elevated GIP levels in obesity may affect markers of liver injury through microRNAs. The study involved 128 subjects (body mass index (BMI) 25–40). Fasting and postprandial GIP, glucose, insulin, and lipids, as well as fasting alanine aminotransferase (ALT), γ-glutamyltransferase (GGT), cytokeratin-18, fibroblast growth factor (FGF)-19, and FGF-21 were determined. TaqMan low density array was used for quantitative analysis of blood microRNAs. Fasting GIP was associated with ALT [β = 0.16 (confidence interval (CI): 0.01–0.32)], triglycerides [β = 0.21 (95% CI: 0.06–0.36], and FGF-21 [β = 0.20 (95%CI: 0.03–0.37)]; and postprandial GIP with GGT [β = 0.17 (95%CI: 0.03–0.32)]. The odds ratio for elevated fatty liver index (>73%) was 2.42 (95%CI: 1.02–5.72) for high GIP versus low GIP patients. The miRNAs profile related to a high GIP plasma level included upregulated miR-136-5p, miR-320a, miR-483-5p, miR-520d-5p, miR-520b, miR-30e-3p, and miR-571. Analysis of the interactions of these microRNAs with gene expression pathways suggests their potential contribution to the regulation of the activity of genes associated with insulin resistance, fatty acids metabolism, and adipocytokines signaling. Exaggerated fasting and postprandial secretion of GIP in obesity are associated with elevated liver damage markers as well as FGF-21 plasma levels. Differentially expressed microRNAs suggest additional, epigenetic factors contributing to the gut–liver cross-talk.

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MicroRNA-320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor-1α

Cited by 27 publications

References 38 publications

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis

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