2011
DOI: 10.4161/rna.8.5.16153
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MicroRNA-30c promotes human adipocyte differentiation and co-repressesPAI-1andALK2

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Cited by 120 publications
(84 citation statements)
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References 59 publications
(85 reference statements)
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“…The higher miR-26b and -30b levels that we observed in IS subjects may stimulate adipogenesis and terminal adipocyte differentiation; in primary human adipocyte culture, miR-26b is upregulated during differentiation, miR26b knock-down inhibits differentiation, and miR-26b overexpression enhances brite adipogenesis (23). Similarly, miR-30 family members contribute to thermogenesis (20), are upregulated during adipocyte differentiation (12), and their expression can directly impact adipogenesis (22,46). miR-145.…”
Section: Discussionmentioning
confidence: 90%
“…The higher miR-26b and -30b levels that we observed in IS subjects may stimulate adipogenesis and terminal adipocyte differentiation; in primary human adipocyte culture, miR-26b is upregulated during differentiation, miR26b knock-down inhibits differentiation, and miR-26b overexpression enhances brite adipogenesis (23). Similarly, miR-30 family members contribute to thermogenesis (20), are upregulated during adipocyte differentiation (12), and their expression can directly impact adipogenesis (22,46). miR-145.…”
Section: Discussionmentioning
confidence: 90%
“…In differentiating adipocytes, miR-30c is up-regulated and silences ALK-2 expression (Karbiener et al 2011); miR-148b and miR-365 target the 3 0 -untranslated region of ALK-2 mRNA (Mura et al 2012); down-regulation of ALK-2 mRNA by miR-148a is relevant for the cancer stem-cell population in hepatocellular carcinoma (Li et al 2015); in the liver, BMP signaling is coordinated with the homeostasis of iron; and, after depletion of iron levels, miR-130a expression is up-regulated causing ALK-2 silencing and decrease in BMP-6 signaling, leading to down-regulation of the BMP target gene hepcidin, which produces the liver hormone that regulates iron homeostasis (Zumbrennen-Bullough et al 2014).…”
Section: Control Of Tgf-b Receptor Expression By Micrornasmentioning
confidence: 99%
“…Many miRNAs have been reported to be involved in the regulation of adipogenic differentiation, such as miR-143, miR-17-92, miR-130, miR-138, miR-17-5p, miR-106a, miR-210, miR-709, miR-137, and miR-302 [36][37][38][39][40][41][42][43][44]. However, few miRNAs have been reported in association with obesity and the positive regulation of adipogenesis [45]. Therefore, future studies are warranted to understand the exact role of obesity-associated miRNAs in the adipogenic differentiation of AMSCs.…”
Section: Introductionmentioning
confidence: 99%