MicroRNA-29c-3p in dual-labeled exosome is a potential diagnostic marker of subjective cognitive decline

Li, Ying; Xia, Ming; Meng, Shuang; Wu, Di; Ling, Sihai; Chen, Xiali; Liu, Chengeng

doi:10.1016/j.nbd.2022.105800

Cited by 14 publications

(15 citation statements)

References 30 publications

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“…There is an increasing interest in exosomes as potential diagnostic agents for exosomes reflect the disease state [28][29][30][31][32][33][34][35][48][49][50][51][52]62,64,65,68,69]. In addition, recent studies give attention to MSC-derived exosomes as potential therapeutic agents due to their immunomodulatory [3 & ] and neuroprotective [70] effects.…”

Section: Discussionmentioning

confidence: 99%

“…In AD patients, blood-derived exosomes, exosomal miR-30b-5p, miR-22-3p, miR-378a-3p [35], miR-125b, miR-361 [29], miR-320a, miR-204-5p, and miR-328-3p [28] were suggested to be potential AD markers. In addition, small neuron-derived exosomal let-7e [34], Neural cell adhesion molecule (NCAM)/amphiphysin 1 dual-labeled exosomal miR-29c-3p [32], and ABCA1-labeled exosomal miR-193b [31] served as AD markers. Other studies reported exosomal GAP43, neurogranin, SNAP25, synaptotagmin 1 [33], Alpha1-antichymotrypsin (AACT), and C4BPa [30] as AD protein markers.…”

Section: Key Pointsmentioning

confidence: 99%

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Exosomes for the diagnosis and treatment of dementia

Joo

Jeon

Hong³

et al. 2023

Current Opinion in Psychiatry

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Purpose of reviewDementia is a syndrome with several possible pathologies. To date, definitive methods for diagnosis and treatment of sub-types of dementia have not been established. Emerging evidence suggests that exosomes can provide important information for the diagnosis and treatment of several subtypes of dementia. This article reviews recent studies on the application of exosomes in dementia.Recent findingsExosomes are involved in the pathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD) through transporting toxic proteins such as amyloid beta (Aβ), tau, and α-synuclein. Exosomal microRNAs (miR) and proteins reflect the disease state, and therefore, exosomes can be used as diagnostic markers for diseases such as AD, PD, Huntington's disease (HD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). Mesenchymal stem cell (MSC)-derived exosomes have been shown to ameliorate disease pathology, and improve cognitive function in AD, PD, and VAD.SummaryRecent studies have shown that exosomes could be novel diagnostic agents for dementia because they contain molecules that could be potential biomarker candidates indicative of the type and stage of dementia. Therapeutic application of exosomes in dementia has revealed that exosomes only, or exosomes loaded with an active pharmaceutical ingredient (API), ameliorate disease phenotype of dementia. Further work is needed to exploit this potential.

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Section: Discussionmentioning

confidence: 99%

Section: Key Pointsmentioning

confidence: 99%

Exosomes for the diagnosis and treatment of dementia

Joo

Jeon

Hong³

et al. 2023

Current Opinion in Psychiatry

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“…miRNAs, such as miR‐9‐5p, miR‐598, miR‐125b, miR‐29, miR‐342‐3p, and miR‐193b, are highly stable and resistant to degradation in exosomes before the onset of AD, suggesting their promising roles as biomarkers for the early clinical diagnosis and monitoring of AD 182,183 . miR‐29c‐3p, miR‐384, and nerve cell adhesion molecule in double‐labeled exosomes have the potential for early diagnosis of AD 184,185 . Serum exosomal miR‐185‐5p was significantly downregulated in AD patients and mice as compared with the control group.…”

Section: Exosomes In Neuropsychiatric Disordersmentioning

confidence: 99%

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Pang

et al. 2023

MedComm

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Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally secreted by cells into body fluids. They are derived from endosomes and are wrapped in lipid membranes. Exosomes are involved in intracellular metabolism and intercellular communication. They contain nucleic acids, proteins, lipids, and metabolites from the cell microenvironment and cytoplasm. The contents of exosomes can reflect their cells’ origin and allow the observation of tissue changes and cell states under disease conditions. Naturally derived exosomes have specific biomolecules that act as the “fingerprint” of the parent cells, and the contents changed under pathological conditions can be used as biomarkers for disease diagnosis. Exosomes have low immunogenicity, are small in size, and can cross the blood–brain barrier. These characteristics make exosomes unique as engineering carriers. They can incorporate therapeutic drugs and achieve targeted drug delivery. Exosomes as carriers for targeted disease therapy are still in their infancy, but exosome engineering provides a new perspective for cell‐free disease therapy. This review discussed exosomes and their relationship with the occurrence and treatment of some neuropsychiatric diseases. In addition, future applications of exosomes in the diagnosis and treatment of neuropsychiatric disorders were evaluated in this review.

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“…Amphiphysin 1, specific for microRNAs and exosome components, has a role with neuronal adhesion molecules [ 60 , 67 – 69 ]. Additional markers can be used to reveal physical conditions of AD patients [ 70 , 71 ].…”

Section: Role Of Ups In Diseasesmentioning

confidence: 99%

Unconventional protein secretion (UPS): role in important diseases

Meldolesi

2023

Mol Biomed

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Unconventional protein secretion (UPS) is the new secretion process discovered in liquid form over three decades ago. More recently, UPS has been shown to operate also in solid forms generated from four types of organelles: fractions of lysosomes and autophagy (APh) undergoing exocytosis; exosomes and ectosomes, with their extracellular vesicles (EVs). Recently many mechanisms and proteins of these solid forms have been shown to depend on UPS. An additional function of UPS is the regulation of diseases, often investigated separately from each other. In the present review, upon short presentation of UPS in healthy cells and organs, interest is focused on the mechanisms and development of diseases. The first reported are neurodegenerations, characterized by distinct properties. Additional diseases, including inflammasomes, inflammatory responses, glial effects and other diseases of various origin, are governed by proteins generated, directly or alternatively, by UPS. The diseases most intensely affected by UPS are various types of cancer, activated in most important processes: growth, proliferation and invasion, relapse, metastatic colonization, vascular leakiness, immunomodulation, chemoresistence. The therapy role of UPS diseases depends largely on exosomes. In addition to affecting neurodegenerative diseases, its special aim is the increased protection against cancer. Its immense relevance is due to intrinsic features, including low immunogenicity, biocompatibility, stability, and crossing of biological barriers. Exosomes, loaded with factors for pharmacological actions and target cell sensitivity, induce protection against various specific cancers. Further expansion of disease therapies is expected in the near future.

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MicroRNA-29c-3p in dual-labeled exosome is a potential diagnostic marker of subjective cognitive decline

Cited by 14 publications

References 30 publications

Exosomes for the diagnosis and treatment of dementia

Exosomes for the diagnosis and treatment of dementia

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Unconventional protein secretion (UPS): role in important diseases

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