MicroRNA-29b inhibits peritoneal fibrosis in a mouse model of peritoneal dialysis

The expression profiling and ontology analysis of noncoding RNAs in peritoneal fibrosis induced by peritoneal dialysis fluid

“…The miRNAs miR-21, miR-30a, miR-155 and miR-29 have been confirmed to be involved in fibrosis Bhattacharyya et al, 2013;Yamada et al, 2013;Zhou et al, 2013). Furthermore, miR-29 and miR-30a were reported to have the ability to ameliorate peritoneal fibrosis in animal models of PD Yu et al, 2014), However, more research is needed to elucidate the complicated relationship between miRNAs and peritoneal fibrosis.…”

Nano-sized carriers in gene therapy for peritoneal fibrosisin vivo

“…This delivery method was shown to maintain overexpression of Smad7 in the peritoneum for up to 2 weeks and inhibited peritoneal fibrosis in a rat peritoneal fibrosis model [43]. Ultrasound-microbubble-mediated delivery of plasmid DNA expressing miRNA-29b and miRNA-30a to the peritoneum induced overexpression of the respective miRNAs in the peritoneum and inhibited mesothelial–mesenchymal transition of peritoneal mesothelial cells, resulting in inhibition of peritoneal fibrosis in a mouse peritoneal fibrosis model, by inhibiting TGF-β 1 and Snail signaling pathways, respectively [44,45]. …”

“…Various nano-sized carriers, including viral and non-viral vectors, have been studied for the gene therapy of peritoneal fibrosis (Figure 2) [34–45]. The different categories of vectors, transgenes, and administration routes, and their effects on peritoneal fibrosis in vivo are summarized in Table 1.…”

Peritonitis-induced peritoneal injury models for research in peritoneal dialysis review of infectious and non-infectious models

“…Daily intraperitoneal exposure of 1.5-3.0 ml of 4.25% glucose PDF for 4 or 5 weeks, with or without implanting a catheter, produced peritoneal dysfunction and morphological changes, such as fibrosis and neoangiogenesis, in mice [78][79][80][81][82][83].…”

“…Other models of non-infectious peritoneal injury associated with inflammation and fibrosis Administration of PDF into the abdominal cavity of rats and mice by repeated intraperitoneal injection or implanting a catheter is a method used to study the pathophysiological changes of the peritoneum associated with PD [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83], but a non-peritonitis model. Daily intraperitoneal injection of 4.25% glucose dialysate into the rat abdominal cavity for 1 week induced an increased peritoneal membrane transport rate and the absence of the peritoneal surface layer, as observed by electron microscopy [69,70].…”