MicroRNA-29a Is a Candidate Biomarker for Alzheimer’s Disease in Cell-Free Cerebrospinal Fluid

Müller, Maria; Jäkel, Lieke; Bruinsma, Ilona B.; Claassen, Jurgen A.H.R.; Kuiperij, H. Bea; Verbeek, Marcel M.

doi:10.1007/s12035-015-9156-8

Cited by 126 publications

(92 citation statements)

References 27 publications

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“…For instance, up-regulated miR-34 is detected in AD-affected cells, which represses the degradation of tau and causes memory impairment through SIRT1 inhibition [284, 285]. Whereas, down-regulation of miR-29a in AD notably induces the expression of its downstream target BACE1 , which accelerates the cleavage from APP to Aβ [286, 287]. Moreover, several elevated miRNAs such as miR-9, miR-155, miR-146a stimulate neuro-inflammation around brain cells, which is a widely recognized mechanism for AD genesis [282].…”

Section: Major Cancer-related Signaling Pathways With Links To Ad mentioning

confidence: 99%

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology

Guo

Cheng²,

North

2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Alzheimer’s disease (AD) is an aging-related neurodegenerative disease and accounts for majority of human dementia. The hyper-phosphorylated tau-mediated intracellular neurofibrillary tangle and amyloid β-mediated extracellular senile plaque are characterized as major pathological lesions of AD. Different from the dysregulated growth control and ample genetic mutations associated with human cancers, AD displays damage and death of brain neurons in the absence of genomic alterations. Although various biological processes predominately governing tumorigenesis such as inflammation, metabolic alteration, oxidative stress and insulin resistance have been associated with AD genesis, the mechanistic connection of these biological processes and signaling pathways including mTOR, MAPK, SIRT, HIF, and the FOXO pathway controlling aging and the pathological lesions of AD are not well recapitulated. Hence, we performed a thorough review by summarizing the physiological roles of these key cancer-related signaling pathways in AD pathogenesis, comprising of the crosstalk of these pathways with neurofibrillary tangle and senile plaque formation to impact AD phenotypes. Importantly, the pharmaceutical investigations of anti-aging and AD relevant medications have also been highlighted. In summary, in this review, we discuss the potential role that cancer-related signaling pathways may play in governing the pathogenesis of AD, as well as their potential as future targeted strategies to delay or prevent aging-related diseases and combating AD.

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Section: Major Cancer-related Signaling Pathways With Links To Ad mentioning

confidence: 99%

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology

Guo

Cheng²,

North

2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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“…RNAs that have been shown to play a role in modulating HIV-1 infection, either directly or indirectly (Monteleone et al, 2015;Müller et al, 2016;Su, Aloi, & Garden, 2016;Swaminathan, Navas-Martín, & Martín-García, 2014).…”

Section: Introductionmentioning

confidence: 99%

A pilot study on the effects of probiotic supplementation on neuropsychological performance and microRNA‐29a‐c levels in antiretroviral‐treated HIV‐1‐infected patients

et al. 2017

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“…Furthermore, miRNA levels in biofluids can be easily detected by standard molecular biology techniques such as quantitative PCR (qPCR). Hence, miRNAs are being considered as potential novel biomarkers in AD (24, 42, 43). …”

Section: Human Disease: Mirnas In Admentioning

confidence: 99%

Alzheimer’s disease: presence and role of microRNAs

Basavaraju

Lencastre

2016

Biomolecular Concepts

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia. AD affects more than 25 million people globally and is predicted to affect nearly one in 85 people worldwide by 2050. AD is characterized by the accumulation of dense plaques of β-amyloid peptide (Aβ) and neurofibrillary tangles of hyperphosphorylated tau that cause impairment in memory, cognition, and daily activities. Although early-onset AD has been linked to several mutations, reliable genetic markers for late-onset AD are lacking. Further, the diagnosis of AD biomarkers has its limitations and cannot detect early-stage AD. The identification of accurate, early, and non-invasive biomarkers for AD is, therefore, an unmet challenge. Recently, micro-RNAs (miRNAs) have emerged as a novel class of gene regulatory elements with conserved roles in development and disease. Recent discoveries have uncovered roles of miRNAs in several model organisms during aging and have identified potential miRNAs biomarkers of AD. Here we will discuss this emerging field of miRNAs associated with AD and prospects for the future.

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MicroRNA-29a Is a Candidate Biomarker for Alzheimer’s Disease in Cell-Free Cerebrospinal Fluid

Cited by 126 publications

References 27 publications

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology

A pilot study on the effects of probiotic supplementation on neuropsychological performance and microRNA‐29a‐c levels in antiretroviral‐treated HIV‐1‐infected patients

Alzheimer’s disease: presence and role of microRNAs

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