MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis

Shi, Dongliang; Shi, Gaofeng; Xie, Jing; Du, Xuzhao; Yang, Hao

doi:10.14348/molcells.2016.0103

Cited by 82 publications

(59 citation statements)

References 36 publications

(45 reference statements)

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“…Findings on Fstl1 in cardiovascular disease, 7,8 cancer, [9][10][11] arthritis, [12][13][14][15][16] lung fibrosis, 17 and obesity 18,19 emphasize its potential as both biomarkers and targets for the management of the disease process. Although the functions and mechanisms of Fstl1 have not been completely understood, a growing body of literatures have identified the critical roles of Fstl1 in the regulation of cell survival, 20,21 proliferation, 22,23 differentiation, 20,22 migration, 23,24 as well as inflammation, 16 and immune modulation. 25 Fstl1 is first discovered as a TGF-β1-induced protein, 26 and has also been shown to function largely through regulating TGF-β/BMP signaling, 5,17 although, in various disease models, different signaling pathways, like activation of AKT, AMPK, or ERK-MAPK, are linked to Fstl1.…”

Section: Introductionmentioning

confidence: 99%

Structural and functional study of FK domain of Fstl1

Chang

et al. 2019

Protein Science

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Fstl1 is a TGF‐β superfamily binding protein which involved in many pathological processes. The function of Fstl1 has been widely elucidated, but its structural characterization has not been explored. Here we solved the high‐resolution crystal structure of FK domain of murine Fstl1, analyzed its unique characteristics, and investigated its contribution to the function of full‐length Fstl1. We found that Fstl1‐FK forms a stable dimer in both solution and crystal, which suggest that this protein may function as a dimer during its interaction with TGF‐β, a molecule known to form dimer during activation process. We also found this FK domain is indispensable for the proper function of Fstl1 during the transduction of TGF‐β signaling. These observations provide important insights into the understanding of Fstl1 and may facilitate the exploration of this molecule in clinical study.

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Section: Introductionmentioning

confidence: 99%

Structural and functional study of FK domain of Fstl1

Chang

et al. 2019

Protein Science

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“…The proliferation and invasion of RA-FLS is related to MMP(69). In RA-FLS, the up-regulation of miR-145-5p (41), miR-18a (34), miR-155 (70,71), miR-203 (42), and the down-regulation of miR-27a (72) were participated in MMP expression through NF-κB pathway (34,41,42), TLR4 (63), and Follistain like-1 (FSTL1) (72). miR-625 was down-regulated in RA-FLS and negatively regulated CTSC, KLF8, EBF3.…”

Section: Mirnas Mediated Fibroblast-like Synoviocytes and Osteocyte Dmentioning

confidence: 99%

Epigenetic Regulation Mediated by miRNA in the Susceptibility and Pathogenesis of Rheumatoid Arthritis

Guo¹,

Chang²,

Xu³

et al. 2020

Preprint

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Contribution:micro-RNA (miRNA) has been demonstrated to play important roles in the transcriptome regulation and disease development including cancer and autoimmune disease such as rheumatoid arthritis. However, a comprehensive role of miRNAs in rheumatoid arthritis (RA) including immune system differentiation and interaction with terminal cells like T cells, fibroblast-like synoviocytes (FLS), osteoblast and osteoclast still unclear. In this review, we have provided a thorough summary on the roles of miRNAs in the susceptibility, pathogenesis, diagnosis, therapeutic intervention and prognosis. We summarized the blood and cell-free miRNA biomarkers which provided novel opportunity to work together with rheumatoid factors (RF), anti-CCP to provide accurate diagnosis and prognosis especially for seronegative patients. Finally, miRNAs were showed as promising biomarker to indicate the DMRDS and immunotherapy efficiency, drug response and resistance. What's more, autotherapeutic effect of miRNA intervention provided promising to develop miRNA based rheumatoid arthritis drugs. Overall, current evidence supports miRNAs as the interesting targets to better understand the pathogenetic mechanism and therapeutic intervention of rheumatoid arthritis.Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 15 April 2020 Abstract micro-RNA (miRNA) has been demonstrated to play important roles in the transcriptome regulation and disease development including cancer and autoimmune disease such as rheumatoid arthritis. However, a comprehensive map on how the mRNAs regulate transcripts, pathways, immune system differentiation and interaction with terminal cells like T cells, fibroblast-like synoviocytes (FLS), osteoblast and osteoclast still unknown. In this review, we have provided a thorough summary on the roles of miRNAs in the susceptibility, pathogenesis, diagnosis, therapeutic intervention and prognosis. Numerous miRNAs were found abnormally expressed in rheumatoid arthritis relevant cells and regulated the target genes and pathways like NF-κB, Fas-FasL, JAK-STAT, IRE1-RIDD, mTOR pathway. In addition, miRNA act as gene expression regulators affect the T cell differentiate to different cell types including Th17 and T-reg cells which provide promising gene therapy target to regulate immune systems in rheumatoid arthritis. We also summarized interesting diagnosis and prognosis roles of blood and cell-free based miRNAs which provided novel opportunity to work together with rheumatoid factors (RF), anti-CCP to provide accurate diagnosis and prognosis especially for seronegative patients. Furthermore, functional genetic variants in miR-499 and miR-146a explained part of missing susceptibility of rheumatoid arthritis. Finally, miRNAs were showed as promising biomarker to indicate the DMRDS and immunotherapy efficiency, drug response and resistance. What's more, autotherapeutic effect of miRNA intervention provided promising to develop miRNA based rheumatoid arthritis drugs. Overall, current evidence supports miRNAs as the inter...

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“…In synovial tissue, altered levels of miR-27a, miR-30a, miR-708 and miR-206, have been found, mainly involved in the invasion of the cartilage by RASFs, enhanced autophagy of RASFs and synovial macrophages, increased RASFs survival and migration, and neovascularization [156][157][158][159]. Besides, altered expression of miR-let-7b, miR-155 and miR-223 in macrophages invading the synovial tissue, influence the development and perpetuation of synovial inflammation.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders

López‐Pedrera

Barbarroja

Patiño-Trives

et al. 2020

IJMS

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Rheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are the systemic autoimmune diseases (SADs) most associated with an increased risk of developing cardiovascular (CV) events. Cardiovascular disease (CVD) in SADs results from a complex interaction between traditional CV-risk factors, immune deregulation and disease activity. Oxidative stress, dyslipidemia, endothelial dysfunction, inflammatory/prothrombotic mediators (cytokines/chemokines, adipokines, proteases, adhesion-receptors, NETosis-derived-products, and intracellular-signaling molecules) have been implicated in these vascular pathologies. Genetic and genomic analyses further allowed the identification of signatures explaining the pro-atherothrombotic profiles in RA, SLE and APS. However, gene modulation has left significant gaps in our understanding of CV co-morbidities in SADs. MicroRNAs (miRNAs) are emerging as key post-transcriptional regulators of a suite of signaling pathways and pathophysiological effects. Abnormalities in high number of miRNA and their associated functions have been described in several SADs, suggesting their involvement in the development of atherosclerosis and thrombosis in the setting of RA, SLE and APS. This review focusses on recent insights into the potential role of miRNAs both, as clinical biomarkers of atherosclerosis and thrombosis in SADs, and as therapeutic targets in the regulation of the most influential processes that govern those disorders, highlighting the potential diagnostic and therapeutic properties of miRNAs in the management of CVD.

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MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis

Cited by 82 publications

References 36 publications

Structural and functional study of FK domain of Fstl1

Structural and functional study of FK domain of Fstl1

Epigenetic Regulation Mediated by miRNA in the Susceptibility and Pathogenesis of Rheumatoid Arthritis

Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders

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