MicroRNA‐23b downregulates peroxiredoxin III in human prostate cancer

He, Hui‐Chan; Zhu, Jianguo; Chen, Xi-bin; Chen, Shan-Ming; Han, Zhengxue; Dai, Qi-Shan; Ling, Xuemei; Fu, Xin; Lin, Zhengfang; Deng, Ye-han; Qin, Guo-qiang; Cai, Chao; Chen, Jiahong; Zhong, Weide

doi:10.1016/j.febslet.2012.06.003

Cited by 50 publications

(30 citation statements)

References 27 publications

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“…miR-23b and miR-383 have been recognized to downregulate the mitochondrial isoform of PRDX family, PRDX III [48, 49]. miR-23b and miR-383 were linked to advanced stage and B-symptoms and miR-383 associated also with poor risk factor profile of limited disease and to more aggressive histological subtype.…”

Section: Discussionmentioning

confidence: 99%

Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas

Karihtala

Porvari

Soini

et al. 2017

Oxidative Medicine and Cellular Longevity

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There are no previous studies assessing the microRNAs that regulate antioxidant enzymes in Hodgkin lymphomas (HLs). We determined the mRNA levels of redox regulating enzymes peroxiredoxins (PRDXs) I–III, manganese superoxide dismutase (MnSOD), nuclear factor erythroid-derived 2-like 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) from a carefully collected set of 41 classical HL patients before receiving any treatments. The levels of redoxmiRs, miRNAs known to regulate the above-mentioned enzymes, were also assessed, along with CD3, CD20, and CD30 protein expression. RNAs were isolated from freshly frozen lymph node samples and the expression levels were analyzed by qPCR. mir23b correlated inversely with CD3 and CD20 expressions (p = 0.00076; r = −0.523 and p = 0.0012; r = −0.507) and miR144 with CD3, CD20, and CD30 (p = 0.030; r = −0.352, p = 0.041; r = −0.333 and p = 0.0032; r = −0.47, resp.). High MnSOD mRNA levels associated with poor HL-specific outcome in the patients with advanced disease (p = 0.045) and high miR-122 levels associated with worse HL-specific survival in the whole patient population (p = 0.015). When standardized according to the CD30 expression, high miR212 and miR510 predicted worse relapse-free survival (p = 0.049 and p = 0.0058, resp.). In conclusion, several redoxmiRs and redox regulating enzyme mRNA levels associate with aggressive disease outcome and may also produce prognostic information in classical HL.

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Section: Discussionmentioning

confidence: 99%

Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas

Karihtala

Porvari

Soini

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…In colon cancer stem cells (CSCs), the forkhead box protein 1, FOXM1, activates transcription of PRDX3 and the expression of CD133 (98). In medulloblastoma tumor tissue samples and cell lines, the level of the microRNA, miR-383, is a modulator of PRDX3 expression (99), whereas in human prostate cancer cells, miR-23b directly regulates PRDX3 expression under normal and hypoxic conditions (100). Finally, in von Hippel-Lindau (VHL)-deficient clear cell renal cell carcinoma (CCRCC), the transcription factor, hypoxia-inducible factor 1 (HIF-1), downregulates the level of PRDX3 (101).…”

Section: Prdxs In Tumorigenesismentioning

confidence: 99%

The role of peroxiredoxins in cancer

Nicolussi

D’Inzeo

Capalbo

et al. 2017

Molecular and Clinical Oncology

151

126

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Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22–27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite. They are highly involved in the control of various physiological functions, including cell growth, differentiation, apoptosis, embryonic development, lipid metabolism, the immune response, as well as cellular homeostasis. Although the protective role of PRDXs in cardiovascular and neurological diseases is well established, their role in cancer remains controversial. Increasing evidence suggests the involvement of PRDXs in carcinogenesis and in the development of drug resistance. Numerous types of cancer cells, in fact, are characterized by an increase in reactive oxygen species (ROS) production, and often exhibit an altered redox environment compared with normal cells. The present review focuses on the complex association between oxidant balance and cancer, and it provides a brief account of the involvement of PRDXs in tumorigenesis and in the development of chemoresistance.

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“…miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes such as MnSOD and GSHPx (197). In addition, miR23b downregulates PRDX3 in human prostate cancer (62). miR-210, nicknamed ''the hypoximir,'' is strongly induced in response to hypoxia and represses mitochondrial respiration, in addition to several other important effects (30).…”

Section: Protecting Mitochondrial Functionmentioning

confidence: 99%

The Use of microRNAs to Modulate Redox and Immune Response to Stroke

Ouyang

Stary

White

et al. 2015

Antioxidants & Redox Signaling

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Significance: Cerebral ischemia is a major cause of death and disability throughout the world, yet therapeutic options remain limited. The interplay between the cellular redox state and the immune response plays a critical role in determining the extent of neural cell injury after ischemia and reperfusion. Excessive amounts of reactive oxygen species (ROS) generated by mitochondria and other sources act both as triggers and effectors of inflammation. This review will focus on the interplay between these two mechanisms. Recent Advances: MicroRNAs (miRNAs) are important post-transcriptional regulators that interact with multiple target messenger RNAs coordinately regulating target genes, including those involved in controlling mitochondrial function, redox state, and inflammatory pathways. This review will focus on the regulation of mitochondria, ROS, and inflammation by miRNAs in the chain of deleterious intra-and intercellular events that lead to brain cell death after cerebral ischemia. Critical Issues: Although pretreatment using miRNAs was effective in cerebral ischemia in rodents, testing treatment after the onset of ischemia is an essential next step in the development of acute stroke treatment. In addition, miRNA formulation and delivery into the CNS remain a challenge in the clinical translation of miRNA therapy. Future Directions: Future research should focus on post-treatment and potential clinical use of miRNAs. Antioxid. Redox Signal. 22,[187][188][189][190][191][192][193][194][195][196][197][198][199][200][201][202]

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MicroRNA‐23b downregulates peroxiredoxin III in human prostate cancer

Cited by 50 publications

References 27 publications

Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas

Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas

The role of peroxiredoxins in cancer

The Use of microRNAs to Modulate Redox and Immune Response to Stroke

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