MicroRNA-223 Is Commonly Repressed in Hepatocellular Carcinoma and Potentiates Expression of Stathmin1

Wong, Queenie Wing-Lei; Lung, Raymond Wai Ming; Law, Priscilla T-Y.; Lai, Paul B.S.; Chan, Kathy Yuen Yee; To, Ka‐Fai; Wong, Nathalie

doi:10.1053/j.gastro.2008.04.003

Cited by 403 publications

(345 citation statements)

References 47 publications

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“…These cells were selected on the basis of their relatively high levels of miR122 expression 24,27 . Several mismatches were intentionally inserted into the RNA hairpin sequences to produce more stable templates for miR122 binding and sequestration and to perturb the participation of miR122 in RNA-induced silencing complex-associated inhibition of translation (Fig.…”

Section: Establishment Of Mir122-silenced Hcc Cell Linesmentioning

confidence: 99%

MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma

et al. 2011

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α-fetoprotein (AFP) is not only a widely used biomarker in hepatocellular carcinoma (HCC) surveillance, but is also clinically recognized as linked with aggressive tumour behaviour. Here we show that deregulation of microRnA122, a liver-specific microRnA, is a cause of both AFP elevation and a more biologically aggressive phenotype in HCC. We identify CuX1, a direct target of microRnA122, as a common central mediator of these two effects. using liver tissues from transgenic mice in which microRnA122 is functionally silenced, an orthotopic xenograft tumour model, and human clinical samples, we further demonstrate that a microRnA122/ CuX1/microRnA214/ZBTB20 pathway regulates AFP expression. We also show that the microRnA122/CuX1/RhoA pathway regulates the aggressive characteristics of tumours. We conclude that microRnA122 and associated signalling proteins may represent viable therapeutic targets, and that serum AFP levels in HCC patients may be a surrogate marker for deregulated intracellular microRnA122 signalling pathways in HCC tissues.

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Section: Establishment Of Mir122-silenced Hcc Cell Linesmentioning

confidence: 99%

MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma

et al. 2011

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“…Probably its repression leads to an increase of the c-myc expression. The re-expression of miR-223 in HBV-, HCV-, and non-HBV-non-HCV-related HCC cell lines revealed a consistent inhibitory effect on cell viability (Wong et al, 2008). Furthermore, Yang et al (2013) demonstrated that miR-223 overexpression plays an important role in the regulation of multidrug resistance (MDR) through downregulation of the ABCB1 expression by increasing the HCC cell sensitivity to anticancer drugs.…”

Section: Mir-223mentioning

confidence: 96%

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

Bronte

Fanale

et al. 2016

Critical Reviews in Oncology/Hematology

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“…Hepatic miR-223 levels were found to be significantly increased upon ischemic/reperfusion injury (16) and decreased in hepatocellular carcinoma (17). There is a growing list of miRNAs that have been reported to regulate individual mechanisms within cholesterol metabolism (18,19); however, miR-223 as a regulatory hub likely links multiple facets of the complex cholesterol metabolic network.…”

mentioning

confidence: 99%

MicroRNA-223 coordinates cholesterol homeostasis

Vickers

Landstreet

Levin

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

226

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Significance Results from this study represent a breakthrough in our understanding of posttranscriptional control of cholesterol metabolism and how microRNAs (miRNAs) are at the heart of cholesterol regulatory circuitry and homeostasis. Although cells are adept at maintaining proper cholesterol levels, it was unknown how cells posttranscriptionally coordinate cholesterol uptake, efflux, and synthesis. MicroRNA-223 (miR-223) transcription and expression are maintained by cholesterol, and, as a feedback network, miR-223 inhibits cholesterol biosynthesis and uptake and increases cholesterol efflux. This study clearly demonstrates the extensive role that miRNAs play in coordinating metabolic adaptation to disease and general homeostasis. This work highlights a unique regulatory control point for cholesterol homeostasis and illustrates how important the study of miRNAs is to the greater understanding of dyslipidemia and cardiovascular disease.

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MicroRNA-223 Is Commonly Repressed in Hepatocellular Carcinoma and Potentiates Expression of Stathmin1

Cited by 403 publications

References 47 publications

MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma

MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

MicroRNA-223 coordinates cholesterol homeostasis

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