microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

Penna, Elisa; Orso, Francesca; Cimino, Daniela; Enrico, Tenaglia; Lembo, Antonio; Quaglino, Elena; Poliseno, Laura; Haimovic, Adele; Osella‐Abate, Simona; Pittà, Cristiano De; Pinatel, Eva; Stadler, Michael; Provero, Paolo; Bernengo, Maria Grazia; Osman, Iman; Taverna, Daniela

doi:10.1038/emboj.2011.102

Cited by 232 publications

(285 citation statements)

References 71 publications

Supporting

Mentioning

271

Contrasting

Order By: Relevance

“…Evidence shows that re-expression of miR200 family members suppresses anoikis resistance in breast cancer cells [131,138,139]. In addition, Penna et al [140] recently showed that during melanoma progression miR214 is up-regulated and positively enhances cell movement and survival to anoikis in vitro as well as metastasis formation in vivo.…”

Section: Taddei Et Almentioning

confidence: 99%

Anoikis: an emerging hallmark in health and diseases

Taddei

Giannoni

Fiaschi

et al. 2011

The Journal of Pathology

466

404

View full text Add to dashboard Cite

Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing dysplastic cell growth or attachment to an inappropriate matrix. Anoikis prevents detached epithelial cells from colonizing elsewhere and is thus essential for tissue homeostasis and development. As anchorage-independent growth and epithelial-mesenchymal transition, two features associated with anoikis resistance, are crucial steps during tumour progression and metastatic spreading of cancer cells, anoikis deregulation has now evoked particular attention from the scientific community. The aim of this review is to analyse the molecular mechanisms governing both anoikis and anoikis resistance, focusing on their regulation in physiological processes, as well as in several diseases, including metastatic cancers, cardiovascular diseases and diabetes.

show abstract

Section: Taddei Et Almentioning

confidence: 99%

Anoikis: an emerging hallmark in health and diseases

Taddei

Giannoni

Fiaschi

et al. 2011

The Journal of Pathology

466

404

View full text Add to dashboard Cite

show abstract

“…8 In patients with cutaneous melanomas, Dicer upregulation was significantly associated with an increased tumor mitotic index, Breslow's depth of invasion, nodal metastasis, and a higher American Joint Committee on Caner (AJCC) clinical stage. 7 Based on microarray hybridization or real-time quantitative RT-PCR (qRT-PCR), results show specific miRNAs being deregulated in some melanoma cell lines, 9,[10][11][12][13] in melanoma metastases, 14 and in primary melanomas. [15][16][17] Moreover, an expression signature, consisting of 18 miRNAs identified in metastatic specimens, significantly correlated with longer survival in a cohort of melanoma patients.…”

mentioning

confidence: 99%

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing

Babapoor

Kozubek

et al. 2017

Laboratory Investigation

View full text Add to dashboard Cite

A comprehensive repertoire of human microRNAs (miRNAs) that could be involved in early melanoma invasion into the dermis remains unknown. To this end, we sequenced small RNAs (18-30 nucleotides) isolated from an annotated series of invasive melanomas (average invasive depth, 2.0 mm), common melanocytic nevi, and matched normal skin (n = 28). Our previously established bioinformatics pipeline identified 765 distinct mature known miRNAs and defined a set of top 40 list that clearly segregated melanomas into thin (0.75 mm) and thick (2.7 mm) groups. Among the top, miR-21-5p, let-7b-5p, let-7a-5p, miR-424-5p, miR-423-5p, miR-21-3p, miR-199b-5p, miR-182-5p, and miR-205-5p were differentially expressed between thin and thick melanomas. In a validation cohort (n = 167), measured expression of miR-21-5p and miR-424-5p, not previously reported in melanoma, were significantly increased in invasive compared with in situ melanomas (Po0.0001). Increased miR-21-5p levels were significantly associated with invasive depth (P = 0.038), tumor mitotic index (P = 0.038), lymphovascular invasion (P = 0.0036), and AJCC stage (P = 0.038). In contrast, let-7b levels were significantly decreased in invasive and in situ melanomas compared with common and dysplastic nevi (Po0.0001). Decreased let-7b levels were significantly associated with invasive depth (P = 0.011), Clark's level (P = 0.013), ulceration (P = 0.0043), and AJCC stage (P = 0.011). These results define a distinct set of miRNAs associated with invasive and aggressive melanoma phenotype. Notwithstanding the distinct sets of DNA and chromosomal alterations demonstrated in melanoma, the changes in the noncoding RNA transcriptome remain poorly understood. The microRNAs (miRNAs) are endogenous, noncoding small (18-24 nucleotides) RNAs, which can regulate gene expression in animals and plants by complementary base-pairing to the mRNAs of target genes to specify mRNA cleavage or translation repression. 1 Growing evidence has shown that particular miRNAs function predominately as tumor suppressors, eg, let-7 family 2,3 and miR-15a and miR-16; 4 and some as oncogenes, eg, miR-17~92 cluster. 5,6 A number of studies have demonstrated an evolving role of miRNAs in various aspects of melanoma biology and clinical behavior. For example, results showed a cell-specific upregulated Dicer expression in 81% of cutaneous, 80% of acrolentiginous, and 96% of metastatic melanomas compared with carcinomas or sarcomas of the skin. 7 Moreover, the expression of Dicer was significantly higher in melanomas compared with benign melanocytic nevi. Dicer, a member of the RNase III family of double-stranded RNases, is a central enzyme in a multi-component miRNA biogenesis pathway where the Drosha/DGCR8 complex and Dicer act sequentially to crop long primary and precursor miRNAs into functionally mature miRNAs. 8 In patients with cutaneous melanomas, Dicer upregulation was significantly associated with an increased tumor mitotic index, Breslow's depth of invasion, nodal metastasis, and a higher American Joi...

show abstract

“…In addition, miR-214 silencing in a highly metastatic lineage, which expressed high levels of this miRNA, caused a significantly reduction of lung metastases formation. Furthermore, as primary tumor growth was not influenced by miR-214, these results indicate miR-214 as a metastamiR with an important role in the melanoma progression [119].…”

Section: Micrornasmentioning

confidence: 63%