microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1

Huang, Peng; Huang, Ping; Xie, Jiabin; Li, Rihong

doi:10.3892/mmr.2017.8006

Cited by 16 publications

(18 citation statements)

References 38 publications

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“…Therefore, targeting ZEB1 may be an efficient strategy for NPC therapy. Previous studies have also identified that ZEB1 was regulated by various miRNAs in human cancer (39)(40)(41). In a previous study, miR-429 was reported to be downregulated in NPC and to suppress cell migration and invasion through targeting ZEB1 (42).…”

Section: Discussionmentioning

confidence: 89%

MicroRNA‑342 inhibits cell proliferation and invasion in nasopharyngeal carcinoma by directly targeting ZEB1

Zhu

Zhang

et al. 2018

Oncol Lett

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Nasopharyngeal carcinoma (NPC) is prevalent in Africa and East Asia, particularly in the southern areas of China. Previous data has demonstrated that microRNAs (miRNAs/miRs) may be involved in the formation and progression of NPC. The deregulation of miR-342 has been identified in multiple types of cancer. However, to the best of our knowledge, there are no data concerning miR-342 in NPC. The present study aimed to measure miR-342 expression in NPC, and to investigate its roles in NPC initiation and progression, in addition to the underlying molecular mechanisms. miR-342 was significantly downregulated in NPC tissues and cell lines. Low miR-342 expression was associated with distant metastasis and tumor node metastasis stage in patients with NPC. The restoration of the expression of miR-342 suppressed cell proliferation and invasion of NPC . In addition, ZEB1 was identified as a direct target gene of miR-342 in NPC. Downregulation of ZEB1 mimicked the tumor-suppressive roles of miR-342 in NPC. Taken together, the present study identified that miR-342 directly targeted ZEB1 to inhibit NPC cell growth and invasion, which may provide a novel therapeutic target for the treatments of patients with this malignancy.

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Section: Discussionmentioning

confidence: 89%

MicroRNA‑342 inhibits cell proliferation and invasion in nasopharyngeal carcinoma by directly targeting ZEB1

Zhu

Zhang

et al. 2018

Oncol Lett

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“…The metastasis of CC was clearly inhibited by miR-3666 and miR-211 through the pituitary tumor-transforming gene 1 ( Pttg1 )/miR-3666/ZEB1 and the miR-211/ZEB1 [124,125] pathways, respectively. Additionally, miR-377 decreases the invasion of CC cells by inversely modulating the expression of ZEB2 [126].…”

Section: The Role Of Emt-related Mirnas In the Metastasis Of CCmentioning

confidence: 99%

The role of miRNAs in the invasion and metastasis of cervical cancer

Wang

Chen

2019

Bioscience Reports

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Cervical cancer (CC) with early metastasis of the primary tumor results in poor prognosis and poor therapeutic outcomes. MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a substantial role in regulating gene expression post-transcriptionally and influence the development and progression of tumors. Numerous studies have discovered that miRNAs play significant roles in the invasion and metastasis of CC by affecting specific pathways, including Notch, Wnt/β-catenin, and phosphoinositide-3 kinase (PI3K)-Akt pathways. miRNAs also effectively modulate the process of epithelial–mesenchymal transition. Many studies provide new insights into the role of miRNAs and the pathogenesis of metastatic CC. In this review, we will offer an overview and update of our present understanding of the potential roles of miRNAs in metastatic CC.

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“…Additionally, in non-small cell lung cancer, ZEB1, as a target of miR-445, reverses its inhibition of the proliferation, migration and invasion [30]. ZEB1 switches with cervical cancer as a target of several miRNAs, such as miR-211, miR-429 and miR-484 [31–33]. In the current study, upregulated expression of ZEB1 was found in cervical cancer tissues.…”

Section: Discussionmentioning

confidence: 58%

The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1

Wang

et al. 2019

Hereditas

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Background Cervical cancer is a malignancy that’s common in female with high incidence and mortality worldwide. MicroRNAs (miRNAs) act a pivotal part in human cancer development. Our aim was to investigate the effect of miR-126 on cervical cancer and its underlying molecular mechanism. Results Firstly, RT-qPCR assay revealed that the expression of miR-126 was significantly downregulated in cervical cancer tissues and cell lines, compared with that in normal adjacent tissues and normal cervical epithelial cell line (Ect1/E6E7), respectively. Then, ZEB1 was verified as a target of miR-126 by using luciferase reporter assay. Inversely, the expression of ZEB1 was markedly upregulated in tumor tissues, and its mRNA level was negatively regulated by miR-126 expression in SiHa and Hela cells. Moreover, the capability of cell proliferation, migration and invasion was analyzed by CCK-8, wound healing assay and transwell assay, respectively. The results demonstrated that overexpression of miR-126 inhibited SiHa and Hela cell proliferation, migration and invasion, while ZEB1 abolished the inhibition induced by miR-126. Additionally, miR-126 suppressed MMP2 and MMP9 in mRNA and protein levels, as well as inhibited the protein expression of p-JAK2 and p-STAT3 in both SiHa and Hela cells, while ZEB1 rescued miR-126-induced suppression. Conclusion miR-126 functions as a tumor suppressor in cervical cancer cells in vitro, which inhibits the proliferation, migration and invasion by suppressing MMP2, MMP9 expression and inactivating JAK2/STAT3 signaling pathway through targeting ZEB1, suggesting that miR-126 might be a novel potential target for the diagnosis and treatment of patients with cervical cancer.

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microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1

Cited by 16 publications

References 38 publications

MicroRNA‑342 inhibits cell proliferation and invasion in nasopharyngeal carcinoma by directly targeting ZEB1

MicroRNA‑342 inhibits cell proliferation and invasion in nasopharyngeal carcinoma by directly targeting ZEB1

The role of miRNAs in the invasion and metastasis of cervical cancer

The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1

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