MicroRNA-210 negatively regulates the radiosensitivity of nasopharyngeal carcinoma cells

Li, Bo‐Yi; Luo, Yi; Zhao, Wensi; Zhang, Lu; Zhou, Hanjing; Zou, Yu‐Chun; Zhang, Tao

doi:10.3892/mmr.2017.6694

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Numerous studies supported that miRNAs mediate the radiosensitivity of cancer cells by regulating target genes. In nasopharyngeal carcinoma cells, miR-210 has been revealed to negatively regulate radiosensitivity ( 33 ). In human cervical carcinoma cells, miR-218 was revealed to promote radiation-induced apoptosis, increasing the radiosensitivity ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

miR‑7/SP1/TP53BP1 axis may play a pivotal role in NSCLC radiosensitivity

et al. 2020

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MicroRNA-7 (miR-7) has been identified as a tumor suppressor in non-small cell lung cancer (NSCLC) and a radiosensitivity regulator. Numerous studies have revealed that specific protein 1 (SP1) plays a critical role in the tumorigenesis of various types of cancers and regulates radiosensitivity and tumor suppressor p53-binding protein 1 (TP53BP1), which plays an essential role in DNA repair. However, it is not clear whether miR-7 has a regulatory effect on SP1 and TP53BP1 in NSCLC. In the present study it was revealed that miR-7 directly binds to the 3′UTR of SP1, thereby suppressing SP1 expression to regulate radiosensitivity. Overexpression of miR-7 and SP1 and knockdown of miR-7 and SP1 were performed using lentiviral transfection. Protein and mRNA abundance of SP1 and TP53BP1 were determined using western blotting and RT-qPCR, respectively, while miR-7 binding to SP1 was validated using a luciferase reporter assay. Biological function analysis indicated that miR-7 negatively regulated SP1 and inhibited cell proliferation, migration, and invasion when combined with radiation. It was also revealed that the expression of TP53BP1 was positively regulated by SP1 or negatively regulated by miR-7. In conclusion, SP1 was a target of miR-7, and the decreased expression of SP1 resulting from miR-7 overexpression in NSCLC was vital for improving radiosensitivity in NSCLC cells. Moreover, SP1 expression was detected in 95 paired NSCLC and adjacent normal tissues, and it was determined that SP1 was significantly upregulated in NSCLC tissues and that its upregulation was correlated with the degree of tissue differentiation. Thus, SP1 and/or miR-7 may be potential molecular targets in NSCLC radiotherapy.

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Section: Discussionmentioning

confidence: 99%

miR‑7/SP1/TP53BP1 axis may play a pivotal role in NSCLC radiosensitivity

et al. 2020

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“…When miR-181a is expressed ectopically, the growth of radioresistant NPC cells is promoted, which has been verified by multiple assays ( 40 ). Moreover, the overexpression of miR-222 and miR-210 reduces the cell apoptosis rate by promoting cell viability, colony formation and tumor growth ( 41 , 42 ). Conversely, miR-31-5p mimics were found to remarkably slow cell proliferation and attenuate radiation resistance by binding to SFN ( 35 ).…”

Section: Resultsmentioning

confidence: 99%

The promising role of miRNAs in radioresistance and chemoresistance of nasopharyngeal carcinoma

Xu,

Li,

Wang

2024

Front. Oncol.

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Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor that develops in the nasopharynx. It has a distinct ethnic and geographical distribution, and emerging evidence suggests that it is an ecological disease. Most patients respond well to radiation combined with chemotherapy as the primary treatment for NPC. However, some patients will eventually develop radio resistance and chemoresistance, resulting in recurrence and metastasis, which is a primary cause of poor prognosis. The processes underlying radio resistance and chemoresistance in NPC are complex and unknown. MicroRNAs (miRNAs) are endogenic non-coding RNA molecules. They play a role in a variety of cell functions as well as development of disease such as cancer. There has been considerable data demonstrating the existence of numerous aberrant miRNAs in cancer tissues, cells, and biofluids, which indicates the importance of studying the influence of miRNAs on NPC. Therefore, this review comprehensively analyzes the elaborate mechanisms of miRNAs affecting the radio resistance and chemoresistance of NPC. Multiple tumor-specific miRNAs can be employed as therapeutic and prognostic biological indicators.

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Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance of Head and Neck Cancer: From Basic Research to Clinical Application

Zhang

Yang

2021

Front. Cell Dev. Biol.

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Head and neck cancers (HNCs) rank as the sixth common and the seventh leading cause of cancer-related death worldwide, with an estimated incidence of 600,000 cases and 40–50% mortality rate every year. Radiotherapy is a common local therapeutic modality for HNC mainly through the function of ionizing radiation, with approximately 60% of patients treated with radiotherapy or chemoradiotherapy. Although radiotherapy is more advanced and widely used in clinical practice, the 5-year overall survival rates of locally advanced HNCs are still less than 40%. HNC cell resistance to radiotherapy remains one of the major challenges to improve the overall survival in HNC patients. Non-coding RNAs (ncRNAs) are newly discovered functional small RNA molecules that are different from messenger RNAs, which can be translated into a protein. Many previous studies have reported the dysregulation and function of ncRNAs in HNC. Importantly, researchers reported that several ncRNAs were also dysregulated in radiotherapy-sensitive or radiotherapy-resistant HNC tissues compared with the normal cancer tissues. They found that ectopically elevating or knocking down expression of some ncRNAs could significantly influence the response of HNC cancer cells to radiotherapy, indicating that ncRNAs could regulate the sensitivity of cancer cells to radiotherapy. The implying mechanism for ncRNAs in regulating radiotherapy sensitivity may be due to its roles on affecting DNA damage sensation, inducing cell cycle arrest, regulating DNA damage repair, modulating cell apoptosis, etc. Additionally, clinical studies reported that in situ ncRNA expression in HNC tissues may predict the response of radiotherapy, and circulating ncRNA from body liquid serves as minimally invasive therapy-responsive and prognostic biomarkers in HNC. In this review, we aimed to summarize the current function and mechanism of ncRNAs in regulating the sensitivity of HNC cancer cells to radiotherapy and comprehensively described the state of the art on the role of ncRNAs in the prognosis prediction, therapy monitoring, and prediction of response to radiotherapy in HNC.

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MicroRNA-210 negatively regulates the radiosensitivity of nasopharyngeal carcinoma cells

Cited by 3 publications

References 38 publications

miR‑7/SP1/TP53BP1 axis may play a pivotal role in NSCLC radiosensitivity

miR‑7/SP1/TP53BP1 axis may play a pivotal role in NSCLC radiosensitivity

The promising role of miRNAs in radioresistance and chemoresistance of nasopharyngeal carcinoma

Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance of Head and Neck Cancer: From Basic Research to Clinical Application

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