MicroRNA-21 as a potential biomarker for detecting esophageal carcinoma in Asian populations: a meta-analysis

Abstract

Background MicroRNA-21 (miR-21) is significantly expressed in a variety of cancers and could be used as a tumor biomarker. However, the results are varied, and no studies on the diagnostic usefulness of miR-21 in Asian esophageal cancer (EC) patients have been published. This meta-analysis was aimed at exploring whether miR-21 can be used as a diagnostic marker and assessing its effectiveness. Methods The relevant literature was identified in six main databases: Ovid MEDLINE, PsycINFO, PubMed MEDLINE, Embase, Web of Science, and the Cochrane Library. Two researchers independently selected the literature based on the inclusion and exclusion criteria, extracted data, and evaluated the risk of bias. The meta-analysis was carried out using Review Manager 5.4, Meta-Disc 1.4 and STATA 15.1 software. In the end, 987 patients from 12 different studies were included. Quality evaluation of diagnostic accuracy studies 2 (QUADAS—2) was used to examine the risk of bias. Results The pooled sensitivity (SEN) was 0.72 (95% CI [0.69–0.75]), the pooled specificity (SPE) was 0.78 (95% CI [0.75–0.81]), the pooled positive likelihood ratio (PLR) was 2.87 (95% CI [2.28–3.59]), the pooled negative likelihood ratio (NLR) was 0.36 (95% CI [0.31–0.43]), the pooled diagnostic odds ratio (DOR) was 10.00 (95% CI [7.73–12.95]), and the area under the curve 0.82 (95% CI [0.79–0.85]). A Deeks’ funnel plot shows that there was no publication bias (P = 0.99). Conclusion Our findings suggest miR-21 might be the potential biomarker for detecting EC in Asian populations, with a good diagnostic value.

Computational Linguistic Analysis for the Isolation of Propitious miRNA Bio- indicators in Esophageal Cancer

“…Regarding the prognosis of esophageal cancer, the concurrent disruption of circulating miR-21 and cytotoxic T lymphocytes (CTLs) presents as prospective diagnostic and prognostic markers for esophageal squamous cell carcinoma (ESCC) 21 . Integrative analysis of miRNA-mRNA expression pro les post-esophageal brosis following ESD 22 ,and MicroRNA-21 as a potential biomarker for detecting esophageal carcinoma in Asian populations have been studied in a meta-analysis 23 .The downregulation of lncRNA LINC-PINT is implicated in the recurrence of esophageal squamous cell carcinoma, possibly interacting with miRNA-21 24 . The correlation of plasma miR-21 and miR-93 with the e cacy of radiotherapy and chemotherapy, and prognosis in esophageal squamous cell carcinoma patients, has also been investigated 25 .…”

Potential Diagnostic Utility of microRNAs in Gastrointestinal Cancers

“…Significant overexpression of miRNA-21 in plasma has been reported also in patients with early-stage esophageal cancer. 30 Chen et al showed that plasma microRNA-375 was significantly different between esophageal cancer patients and controls, but found no difference in gender or age. They evaluated the diagnostic value of miRNA-375 37 EC patients and 26 healthy controls.…”