MicroRNA‑193b regulates human ovarian cancer cell growth via targeting STMN1

Abstract

Ovarian cancer is the eighth most common malignancy among women worldwide. Ovarian cancer exhibits no obvious symptoms in the early stage of tumorigenesis and currently, no effective methods for the early detection and treatment of ovarian cancer have been established. Therefore, the identification of novel targets is critical to the early diagnosis and clinical treatment of ovarian cancer. microRNAs (miRs) are small non-coding RNAs, which serve an important biological role in a number of physiological processes and in oncogenesis. Previous studies have reported that miRNA-193b is dysregulated in a variety of types of human cancer. However, the roles of miRNA-193b in human ovarian cancer has not been determined. The present study investigated the roles of miRNA-193b in human ovarian cancer cells. Reverse transcription-quantitative PCR results indicated that the expression of miRNA-193b in ovarian cancer cells was significantly down-regulated compared with non-malignant cells. Cell counting kit-8 results indicated that the up-regulation of miRNA-193b inhibited ovarian cancer cell proliferation and induced ovarian cancer cell apoptosis. The present study also indicated that stathmin 1 (STMN1) was a direct target of miRNA-193b, and the up-regulation of miRNA-193b significantly decreased the expression of STMN1 in ovarian cancer cells. In conclusion, the results demonstrated that miRNA-193b serves as a tumor suppressor in human ovarian cancer by inhibiting cell proliferation and inducing cell apoptosis. Therefore, the assessment of miRNA-193b may provide insight into a novel diagnostic biomarker and potential therapeutic target for patients with ovarian cancer.

A Differentiation-Related Gene Prognostic Index Contributes to Prognosis and Immunotherapy Evaluation in Patients with Hepatocellular Carcinoma

“…In addition, Liu et al showed that a nomogram constructed from the mRNA expression of plasma HSP90AA1 could predict the risk of breast cancer incidence and metastasis [ 41 ]. Additionally, tubulin STMN1 is up-regulated and has de-stabilizing activity in various tumor tissues [ 42 ], which is associated with the proliferation, invasion, and migration of gastric cancer [ 43 ], ovarian cancer [ 44 ], and HCC [ 45 ]. Interestingly, in the DRGPI risk assessment model constructed by our team, the coefficients of PON1 and ADH4 were negative.…”

M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62

“…miR-193b-3p is involved in different biological and pathological processes. For instance, Li et al reported that miRNA-193b suppresses proliferation and induces apoptosis in ovarian cancer [ 32 ]. miR-193b-3p also inhibits neuroblastoma cell growth [ 33 ].…”

Screening for Prognostic microRNAs Associated with Treatment Failure in Diffuse Large B Cell Lymphoma

“…Interestingly, in FaDu cancer cells (HNSCC) in vitro knockdown of miR-193b substantially reduced cell proliferation and migration, as well as tumor formation in an animal model [ 35 ]. In contrast, in human ovarian cancer cells it has been suggested that miR-193b could act as tumor suppressor by inhibiting cell proliferation and inducing apoptosis [ 36 ]. The lesson to learn from such apparently contradictory observations is that the specific functional role of miRNAs (oncogene or tumor suppressor gene) may vary depending on the tumoral tissue type.…”