MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer

Liang, Changhong; Zhang, Xing; Wang, Huimin; Liu, Xiaomin; Zhang, Xinju; Zheng, Bo; Qian, Guangren; Ma, Zhongliang

doi:10.1038/cddis.2017.145

Cited by 110 publications

(91 citation statements)

References 41 publications

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“…4A, by comparing the correlations of predicted target genes versus nontarget genes, we identified 19 miRNAs as potential key regulators across cancer types by using the KS-testbased approach (see Methods). The top two frequently observed miRNAs is hsa-miR-18a-5p (in seven cancer types), which has been reported to function as an oncogene in renal cell carcinoma (17) and lung cancer (18) and hsa-miR-532-5p (in five cancer types), a tumor suppressor in liver cancer (19). These results supported their regulatory roles in kidney renal clear cell carcinoma, lung squamous cell carcinoma, and hepatocellular carcinoma (Fig.…”

Section: S18supporting

confidence: 63%

TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data

Chen¹,

Li²,

Wang³

et al. 2019

Molecular & Cellular Proteomics

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Reverse-phase protein arrays represent a powerful functional proteomics approach. Using this platform, we have characterized ϳ8,000 patient samples of 32 cancer types through The Cancer Genome Atlas and built a widely used, open-access bioinformatic resource, The Cancer Proteome Atlas (TCPA). Here we have developed a new module called "TCGA Pan-Cancer Analysis," which provides comprehensive protein-centric, pan-cancer analyses in rich context of TCGA data. This upgraded TCPA (v3.0) provides a more valuable tool for studying functional proteomics and making translational impacts.

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Section: S18supporting

confidence: 63%

TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data

Chen¹,

Li²,

Wang³

et al. 2019

Molecular & Cellular Proteomics

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“…For instance, miR-494 suppressed the proliferation and induced apoptosis of ovarian cancer cells, through negatively regulating the fibroblast growth factor receptor 2 oncogene (18). By contrast, several highly expressed miRNAs function as oncogenes during tumor development by repressing tumor suppressor genes (19)(20)(21). For instance, miR-130a enhances the proliferation and migration of gastric cancer cells by targeting transforming growth factor β receptor (TGFβR) 2 (22).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2

Sun

Liu

et al. 2017

Molecular Medicine Reports

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Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-associated mortality worldwide. Non-small cell lung cancer (NSCLC) is the predominant type of lung cancer, and accounts for ~85% of all lung cancer cases. An increasing number of studies suggest that microRNAs (miRs) may be involved in the regulation of NSCLC carcinogenesis and progression. However, the expression and function of miRNA-219 in NSCLC, and its underlying mechanisms of action, remain unknown. In the present study, miR-219 expression in NSCLC tissues and cell lines was determined using reverse transcription-quantitative polymerase chain reaction. Following transfection with miR-219 mimics, the effects of miR-219 overexpression on NSCLC cell proliferation, migration and invasion were examined. Furthermore, the miR-219 target in NSCLC was investigated. miR-219 was observed to be downregulated in NSCLC tissues and NSCLC cell lines. In addition, miR-219 was demonstrated to function as a tumor suppressor in NSCLC, through inhibiting cell proliferation, migration and invasion in vitro. Furthermore, high mobility group AT-hook 2 (HMGA2) was identified to be a direct target of miR-219 in NSCLC, and downregulation of HMGA2 suppressed NSCLC cell proliferation, migration and invasion in vitro. HMGA2 expression was upregulated in NSCLC tissues, and was inversely correlated with miR-219 expression. In conclusion, miR-219 functions as a tumor suppressor and may be important in inhibiting the growth and metastasis of NSCLC cells via directly targeting HMGA2. Therefore, miR-219 may present a potential novel therapeutic target for NSCLC.

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“…In this study, we demonstrated that MT1JP bound to miR-18a-5p to facilitate the expression of FBP1. MiR-18a-5p belongs to miR-17-92 cluster, plays tumor-promoting roles in colorectal cancer, lung cancer and renal cell carcinoma cells [15][16][17]. However, one study reported that miR-18a-5p was downregulated in breast cancer tissues, and inhibited migration and invasion in breast cancer cells [18].…”

Section: Discussionmentioning

confidence: 99%

LncRNA MT1JP Plays a Protective Role in Cholangiocarcinoma by Regulating miR-18a-5p/FBP1 Axie

Zhao

Guo

et al. 2020

Preprint

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Background: Cholangiocarcinoma is a common malignant tumor of digestive system. LncRNA MT1JP has been reported to play tumor-suppressing roles in multiple cancers. However, the effect of MT1JP on cholangiocarcinoma has not been evaluated. Methods: The expression of MT1JP in cholangiocarcinoma specimens and paired para-carcinoma tissues were detected by real-time PCR. The overexpression plasmid and siRNA of MT1JP were transfected into cholangiocarcinoma cells to change the expression levels of MT1JP. CCK-8, flow cytometry and transwell assays were performed to measure proliferation, cell cycle transition, apoptosis, migration and invasion in cholangiocarcinoma cells. Dual-luciferase reporter assay, real-time PCR and western blot were carried out to screen the miRNA bound by MT1JP. In addition, xneograft experiment was used to determine the tumorigenesis of cholangiocarcinoma cells in nude. Results: MT1JP was downregulated in cholangiocarcinoma specimens, compared with para-carcinoma tissues, and its expression was related with tumor size, TNM stage and lymph node metastasis. Overexpression of MT1JP inhibited proliferation, cell cycle transition, migration and invasion, and induced apoptosis in cholangiocarcinoma cells. The knockdown of MT1JP led to opposite results. MT1JP bound to miR-18a-5p to facilitate the expression of fructose-1,6-bisphosphatase 1 (FBP1). MiR-18a-5p was increased in cholangiocarcinoma samples, and its expression was negatively correlated with that of MT1JP. In addition, MT1JP also suppressed tumorigenesis in nude mice. Conclusions: MT1JP alleviated proliferation, migration and invasion, and induced apoptosis in cholangiocarcinoma cells by regulating miR-18a-5p/FBP1 axie. These findings may provide novel insights for diagnosis and treatment of cholangiocarcinoma in clinic.

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MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer

Cited by 110 publications

References 41 publications

TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data

TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data

MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2

LncRNA MT1JP Plays a Protective Role in Cholangiocarcinoma by Regulating miR-18a-5p/FBP1 Axie

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