MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/β-catenin signaling

Wu, Jialin; CHEN, ZEHONG; LIU, WENWEI; ZHANG, YONGXIN; Feng, Wei; YUAN, YUJIE; YE, JINNING; WANG, LIANG; CAI, SHIRONG; HE, YULONG; Wu, Sheng-Yi; SONG, WU

doi:10.32604/or.2022.03178

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…It is expressed in numerous human organs and is known to be an important source of niche signaling in certain stem cells, such as the intestine 65 , 66 . In oncology studies, there is a positive crosstalk between Foxl1 and downstream Wnt/β-catenin signaling activation 67 . Although the detailed molecular mechanism is not very clear in HPCs, based on the significance of the Wnt/β-catenin pathway for HPCs 30 , 62 , 68 , 69 , Foxl1 may assume part of the effect in the pathway.…”

Section: Foxl1 and Hpcs Proliferation-associated Signalingmentioning

confidence: 99%

Transcriptional Control: A Directional Sign at the Crossroads of Adult Hepatic Progenitor Cells' Fates

Xu,

Fang,

Song

et al. 2024

Int. J. Biol. Sci.

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Hepatic progenitor cells (HPCs) have a bidirectional potential to differentiate into hepatocytes and bile duct epithelial cells and constitute a second barrier to liver regeneration in the adult liver. They are usually located in the Hering duct in the portal vein region where various cells, extracellular matrix, cytokines, and communication signals together constitute the niche of HPCs in homeostasis to maintain cellular plasticity. In various types of liver injury, different cellular signaling streams crosstalk with each other and point to the inducible transcription factor set, including FoxA1/2/3, YB-1, Foxl1, Sox9, HNF4α, HNF1α, and HNF1β. These transcription factors exert different functions by binding to specific target genes, and their products often interact with each other, with diverse cascades of regulation in different molecular events that are essential for homeostatic regulation, self-renewal, proliferation, and selective differentiation of HPCs. Furthermore, the tumor predisposition of adult HPCs is found to be significantly increased under transcriptional factor dysregulation in transcriptional analysis, and the altered initial commitment of the differentiation pathway of HPCs may be one of the sources of intrahepatic tumors. Related transcription factors such as HNF4α and HNF1 are expected to be future targets for tumor treatment.

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Section: Foxl1 and Hpcs Proliferation-associated Signalingmentioning

confidence: 99%

Transcriptional Control: A Directional Sign at the Crossroads of Adult Hepatic Progenitor Cells' Fates

Xu,

Fang,

Song

et al. 2024

Int. J. Biol. Sci.

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show abstract

“…In recent years, there has been a growing body of research that has shed light on the significant contribution of non-coding RNAs to the pathogenesis of different types of cancers ( Wu J. et al, 2022 ; Gao et al, 2022 ; Liu et al, 2023 ; Xie et al, 2023 ). Specifically, lncRNAs and the JAK-STAT pathway have emerged as pivotal factors in the initiation and advancement of CRC ( Li B. et al, 2022 ).…”

Section: Future Prospectsmentioning

confidence: 99%

Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer development

Ghasemian,

Omear,

Mansoori

et al. 2023

Front. Genet.

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Colorectal cancer (CRC) is one of the main fatal cancers. Cell signaling such as Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling substantially influences the process of gene expression and cell growth. Long non-coding RNAs (lncRNAs) play regulatory roles in cell signaling, cell proliferation, and cancer fate. Hence, lncRNAs can be considered biomarkers in cancers. The inhibitory or activating effects of different lncRNAs on the JAK/STAT pathway regulate cancer cell proliferation or tumor suppression. Additionally, lncRNAs regulate immune responses which play a role in immunotherapy. Mechanisms of lncRNAs in CRC via JAK/STAT regulation mainly include cell proliferation, invasion, metastasis, apoptosis, adhesion, and control of inflammation. More profound findings are warranted to specifically target the lncRNAs in terms of activation or suppression in hindering CRC cell proliferation. Here, to understand the lncRNA cross-talk in CRC through the JAK/STAT signaling pathway, we collected the related in vitro and in vivo data. Future insights may pave the way for the development of novel diagnostic tools, therapeutic interventions, and personalized treatment strategies for CRC patients.

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Investigating the sensing of B ₂ N ₂ monolayer towards Eriochrome Black T: a computational study

Jabar,

Alwan,

Dawood

et al. 2023

Molecular Physics

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MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/β-catenin signaling

Cited by 3 publications

References 38 publications

Transcriptional Control: A Directional Sign at the Crossroads of Adult Hepatic Progenitor Cells' Fates

Transcriptional Control: A Directional Sign at the Crossroads of Adult Hepatic Progenitor Cells' Fates

Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer development

Investigating the sensing of B ₂ N ₂ monolayer towards Eriochrome Black T: a computational study

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MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/β-catenin signaling

Cited by 3 publications

References 38 publications

Transcriptional Control: A Directional Sign at the Crossroads of Adult Hepatic Progenitor Cells' Fates

Transcriptional Control: A Directional Sign at the Crossroads of Adult Hepatic Progenitor Cells' Fates

Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer development

Investigating the sensing of B 2 N 2 monolayer towards Eriochrome Black T: a computational study

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Investigating the sensing of B ₂ N ₂ monolayer towards Eriochrome Black T: a computational study