MicroRNA-183-3p up-regulated by vagus nerve stimulation mitigates chronic systolic heart failure via the reduction of BNIP3L-mediated autophagy

Ouyang, Shan; Chen, Wei; Zeng, Gaofeng; Chang-cheng, Lei; Tian, Guo-Ping; Zhu, Mingyan; Yang, Liu; Ye, Min

doi:10.1016/j.gene.2019.144136

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…On the other hand, diversified studies have shown that VNS affects disease progression by regulating the expression of miRs. For instance, VNS treatment alleviates chronic systolic heart failure by upregulating miRNA-183-3p [26]. According to the above studies, VNS represses the release of cytokines by inflammatory cells in epilepsy, so as to inhibit the progression of epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation affects inflammatory response and anti-apoptosis reactions via regulating miR-210 in epilepsy rat model

Bie¹,

Wang²,

Chen³

et al. 2021

NeuroReport

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Background Studies have shown that vagus nerve stimulation (VNS) significantly reduces the frequency of seizures. MicroRNAs (miRNAs) in cerebrospinal fluid are expected to become a new biomarker of epilepsy. Therefore, studying the interaction mechanism between the VNS and miRNAs is hopeful of bringing a new therapeutic direction for the treatment of epilepsy.Methods Kainic acid was used to induce the Sprague-Dawley rat epilepsy model, and the rats were treated with VNS. The miR-210 expression was determined by quantitative reverse transcription PCR (qRT-PCR). Racine score was adopted to evaluate the performance of behavioral seizures, whereas qRT-PCR and ELISA were employed to test inflammatory factors. Western blotting was implemented to testify the inflammatory and apoptotic proteins.Results Kainic acid-induced the Sprague-Dawley rat epilepsy model and upregulated the expression of miR-210, inflammatory response, inflammation and apoptosis-related proteins in brain tissues. In addition, compared with the epilepsy model group, miR-210 in the hippocampus of the epilepsy model rats treated with VNS was downregulated, and the expression of apoptosisrelated proteins and inflammatory factors was reduced. Moreover, after further inhibiting the expression of miR-210, the inhibition of VNS on epilepsy, inflammation and apoptosis were significantly enhanced.Summary VNS relieves the inflammatory response and apoptosis of epileptic rats via inhibiting miR-210.

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Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation affects inflammatory response and anti-apoptosis reactions via regulating miR-210 in epilepsy rat model

Bie¹,

Wang²,

Chen³

et al. 2021

NeuroReport

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“…BNIP3L [62], HBA2 [63], SNCA (synuclein alpha) [64], NAT2 [65] and DAO (D-amino acid oxidase) [66] have been reported to have a crucial role in CNS disorders, but these genes might be involved in the progression of COVID-19. Ouyang et al [67], Vendrov et al [68], Alikhah et al [69], Khelil et al [70] and Xia et al [71] found that BNIP3L, NOX4, SOCS1, NAT2, MYOCD (myocardin) and expression were altered in cardiovascular diseases, but these genes might be involved in the progression of COVID-19. HBA2 [72], NOX4 [73], NAT2 [74] and MYOCD (myocardin) [75] are important in the development of hypertension, but these genes might be involved in the progression of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

Vastrad¹,

Vastrad²

2022

Preprint

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The ongoing pandemic of coronavirus disease 2019 (COVID-19) has made a serious public health threat globally. To discover key molecular changes in COVID-19 and its secondary complications, we analyzed next-generation sequencing (NGS) data of COVID-19. NGS data (GSE163151) was screened and downloaded from the Gene Expression Omnibus database (GEO). Differentially expressed genes (DEGs) were identified in the present study, using DESeq2 package in R programming software. Gene ontology (GO) and pathway enrichment analysis were performed, and the protein-protein interaction (PPI) network, module analysis, miRNA-hub gene regulatory network and TF-hub gene regulatory network were established. Subsequently, receiver operating characteristic curve (ROC) analysis was used to validate the diagonostics valuesof the hub genes. Firstly, 954 DEGs (477 up regulated and 477 down regulated) were identified from the four NGS dataset. GO enrichment analysis revealed enrichment of DEGs in genes related to the immune system process and multicellular organismal process, and REACTOME pathway enrichment analysis showed enrichment of DEGs in the immune system and formation of the cornified envelope. Hub genes were identified from the PPI network, module analysis, miRNA-hub gene regulatory network and TF-hub gene regulatory network. Furthermore, the ROC analysis indicate that COVID-19 and its secondary complications with following hub genes, namely, RPL10, FYN, FLNA, EEF1A1, UBA52, BMI1, ACTN2, CRMP1, TRIM42 and PTCH1, had good diagnostics values. This study identified several genes associated with COVID-19 and its secondary complications, which improves our knowledge of the disease mechanism.

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“…MiR-183-3p has been shown to discriminate non-HF-controls from patients with HFrEF but also HFpEF ( 34 ). Moreover, miR-183-3p has been found to be down-regulated in rats with chronic systolic HF and it was shown that treatment of these rats with vagus nerve stimulation resulted in an up-regulation of miR-183-3p along with lower NT-proBNP levels ( 35 ). In that study, Bcl-2 interacting protein 3 like was identified as the target gene of miR-183-3p.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-183-3p Is a Predictor of Worsening Heart Failure in Adult Patients With Transposition of the Great Arteries and a Systemic Right Ventricle

Abu‐Halima

Meese

Abdul‐Khaliq

et al. 2021

Front. Cardiovasc. Med.

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Aim: MicroRNAs (miRNAs) have been shown to play an important role in the progression of heart failure (HF). The aim of our study was to analyze miRNAs in the blood of patients with transposition of the great arteries and a systemic right ventricle (TGA-RV) in order to identify those that predict worsening HF.Materials and Methods: In 36 patients with TGA-RV, SurePrint™ 8 × 60K Human v21 miRNA microarrays were used to determine the miRNA abundance profiles and compared to 35 age- and gender-matched healthy volunteers (HVs). MiRNAs that were most significantly abundant or best related to worsening HF were further validated by RT-qPCR.Results: Using miRNA array analysis, a total of 50 down-regulated and 56 up-regulated miRNAs were found to be differentially abundant in TGA-RV patients compared to HVs. Six of these 106 miRNAs were significantly related to worsening HF. After validation by RT-qPCR, four miRNAs turned out to be significantly associated with worsening HF, namely miR-150-5p, miR-1255b-5p, miR-423-3p, and miR-183-3p. In the stepwise multivariable Cox regression analysis, ejection fraction of the systemic RV, high sensitive TNT and miR-183-3p were found to be independent predictors of worsening HF (P = 0.001, P = 0.002, and P = 0.001, respectively).Conclusions: In patients with TGA-RV, miR-183-3p is an independent predictor of worsening HF and thus may be used as additional biomarker in the risk assessment of these patients.

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MicroRNA-183-3p up-regulated by vagus nerve stimulation mitigates chronic systolic heart failure via the reduction of BNIP3L-mediated autophagy

Cited by 7 publications

References 45 publications

Vagus nerve stimulation affects inflammatory response and anti-apoptosis reactions via regulating miR-210 in epilepsy rat model

Vagus nerve stimulation affects inflammatory response and anti-apoptosis reactions via regulating miR-210 in epilepsy rat model

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

MicroRNA-183-3p Is a Predictor of Worsening Heart Failure in Adult Patients With Transposition of the Great Arteries and a Systemic Right Ventricle

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