MicroRNA-182 Promotes Lipoprotein Lipase Expression and Atherogenesisby Targeting Histone Deacetylase 9 in Apolipoprotein E-Knockout Mice

Cheng, Haipeng; Gong, Duo; Zhao, Zhen-Wang; He, Ping; Yu, Xiaohua; Ye, Qiong; Huang, Chong; Zhang, Xin; Chen, Lingyan; Xie, Wei; Zhang, Min; Li, Liang; Xia, Xiao-Dan; Ouyang, Xin; Tan, Yanhong; Wang, Zongbao; Tian, Guo-Ping; Zheng, Xi-Long; Yin, Wang; Tang, Chao-Ke

doi:10.1253/circj.cj-16-1165

Cited by 21 publications

(13 citation statements)

References 47 publications

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“…qPCR analysis was performed as described previously. 28 Cells total RNA was extracted using TRIzol reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer's introduction. Reverse transcription was conducted by a High-Capacity cDNA reverse transcription kit (Takara).…”

Section: Real-time Quantitative Pcr (Qpcr) Analysismentioning

confidence: 99%

“…Western Blot Analysis Cells were lysed in RIPA buffer (Sigma, St Louis, MO, USA) on ice for protein extraction, as described previously. 19,28 The protein content was assayed by BCA protein assay reagent (Pierce, USA). A sample of 50 µg protein was loaded to SDS-PAGE, and then transferred to the polyvinylidene difluoride (PVDF) (Millipore Corporation, USA) membranes.…”

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confidence: 99%

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MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice

Chen

Xia

Zhao

et al. 2018

Circ J

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Section: Real-time Quantitative Pcr (Qpcr) Analysismentioning

confidence: 99%

mentioning

confidence: 99%

MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice

Chen

Xia

Zhao

et al. 2018

Circ J

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“…Because miR‐92a has anti‐angiogenic activity, it might be used as an atheroprotective miRNA and indicator of endothelial cell migration and the progression of atherosclerosis. MiR‐182 may promote lipid accumulation and increase apoptosis of Ox‐LDL‐induced vascular endothelial cells and inflammation in atherosclerotic lesions like miR‐92a . However, a recent study showed that miR‐182 has a significant role in inhibiting oxidative stress and apoptosis via targeting TLR‐4 in vitro (Figure C).…”

Section: Preclinical Studies Of Mirnas In Atherosclerosismentioning

confidence: 99%

Diagnostic and theranostic microRNAs in the pathogenesis of atherosclerosis

Shoeibi

2019

Acta Physiologica

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MicroRNAs (miRNAs) are a group of small single strand and noncoding RNAs that regulate several physiological and molecular signalling pathways. Alterations of miRNA expression profiles may be involved with pathophysiological processes underlying the development of atherosclerosis and cardiovascular diseases, including changes in the functions of the endothelial cells and vascular smooth muscle cells, such as cell proliferation, migration and inflammation, which are involved in angiogenesis, macrophage function and foam cell formation. Thus, miRNAs can be considered to have a crucial role in the progression, modulation and regulation of every stage of atherosclerosis. Such potential biomarkers will enable us to predict therapeutic response and prognosis of cardiovascular diseases and adopt effective preclinical and clinical treatment strategies. In the present review article, the current data regarding the role of miRNAs in atherosclerosis were summarized and the potential miRNAs as prognostic, diagnostic and theranostic biomarkers in preclinical and clinical studies were further discussed. The highlights of this review are expected to present opportunities for future research of clinical therapeutic approaches in vascular diseases resulting from atherosclerosis with an emphasis on miRNAs. K E Y W O R D Satherosclerosis, diagnosis, miRNA, prognosis, therapeutic approaches 2 of 24 | SHOEIBI Because miRNAs have a relatively high stability under the physiological conditions of mammals, they can be used as prognostic and diagnostic markers for diseases, such as atherosclerosis. This review aims to describe and summarize miRNA expression studies in model animal experiments and clinical practices related to atherosclerosis. The expressed pattern of miRNAs contributing to atherosclerosis at different stages of the atherosclerotic process in comparison with healthy arteries is also discussed.

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“…Moreover, HDAC9 repressed cholesterol efflux by downregulating ABCA1, ABCG1, and PPARγ and alternatively promoted macrophage activation in AS (Cao et al, 2014). On the contrary, it was demonstrated that reduced expression of HDAC9 induced by miR-182 was implicated in increased levels of cholesterol, lipoprotein lipase, and proinflammatory cytokines in oxLDL-treated human THP-1 macrophages, which the author suggested might mediate the lipid accumulation in atherosclerotic lesions and thus promoted atherogenesis in ApoE −/− mice administered with miR-182 agomir (Cheng et al, 2017). Moreover, it was found that HDAC1/2/3/4/6/11 were all upregulated in atherosclerotic carotid arteries and aortas from human and ApoE −/− mice, respectively (Manea et al, 2020).…”

Section: Hdacs Regulate Atherosclerosis In Human and Animalsmentioning

confidence: 99%

Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review

Chen

et al. 2020

Front. Cell Dev. Biol.

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Atherosclerosis (AS), the most common underlying pathology for coronary artery disease, is a chronic inflammatory, proliferative disease in large- and medium-sized arteries. The vascular endothelium is important for maintaining vascular health. Endothelial dysfunction is a critical early event leading to AS, which is a major risk factor for stroke and myocardial infarction. Accumulating evidence has suggested the critical roles of histone deacetylases (HDACs) in regulating vascular cell homeostasis and AS. The purpose of this review is to present an updated view on the roles of HDACs (Class I, Class II, Class IV) and HDAC inhibitors in vascular dysfunction and AS. We also elaborate on the novel therapeutic targets and agents in atherosclerotic cardiovascular diseases.

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MicroRNA-182 Promotes Lipoprotein Lipase Expression and Atherogenesisby Targeting Histone Deacetylase 9 in Apolipoprotein E-Knockout Mice

Cited by 21 publications

References 47 publications

MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice

MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice

Diagnostic and theranostic microRNAs in the pathogenesis of atherosclerosis

Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review

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