MicroRNA-17, MicroRNA-18a, and MicroRNA-19a Are Prognostic Indicators in Esophageal Squamous Cell Carcinoma

MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

“…42,[49][50][51][52][53][54][55][56][57] In addition, miR-19 upregulation was observed in various cancers including lung cancer, and correlated with tumor metastasis and/or poor prognosis of cancer patients. [11][12][13][14][15]18 Given that miRNAs primarily function through inhibiting the translation of their mRNA targets, we propose that miR-19 might be a negative regulator for PTEN, which has been reported by other researchers. 10,29,58,59 In addition, miR-19 increased the resistance to apoptosis of mouse B-cell lymphoma, 10,29 and chemoresistance of human breast cancer 58 and gastric cancer 59 through directly repressing PTEN expression.…”

“…15 Moreover, the expression of miR-19 was significantly higher in the lessinvasive breast cancer MCF7 cells than the more-invasive MDAMB-231 cells, and the expression of a positive regulator of tumor angiogenesis and metastasis was negatively regulated by miR-19 in breast cancer cells, 35 suggesting that miR-19 inhibited the metastasis of breast cancer. In osteosarcoma cells, the expression of miR-19a was higher in metastatic LM7 cells with low expression of Fas than the parental nonmetastatic SAOS-2 cells with high expression of Fas.…”

“…Given that miR-19 is associated with cancer invasion and metastasis and EMT is the central mechanism underlying cancer invasion and metastasis, [10][11][12][13][14][15][16][17][18] the present study aimed to investigate whether miR-19 is able to induce EMT and enhance invasion and metastasis of human cancer cells. Our results showed that enforced expression of miR-19 in lung cancer cells induced EMT, which caused growth inhibition but elevated migration of the cancer cells.…”

“…15 In addition, high levels of serum miR-19a and miR-19b-1 were considered as independent prognostic factors for poor survival of NSCLC patients. 12,13 In a mouse model of c-Myc-driven B-cell lymphomas, Em-myc/miR-19b-1 lymphomas are highly invasive as lymphoma cells invaded the thymus and bone marrow, as well as visceral organs outside the lymphoid compartment, including the liver, lung, and, occasionally, the kidney.…”

Plasma microRNA-19a as a Potential Biomarker for Esophageal Squamous cell Carcinoma Diagnosis and Prognosis

“…miRNAs are small noncoding RNAs of 21-25 nucleotides in length that negatively regulate target genes [12] and play important roles in a wide range of physiological and pathological processes [13,14] Research Article Bai, Lin, Fang et al are frequently located in cancer-associated genomic regions or in fragile sites, indicating that the potential great roles in tumorigenesis [15]. Since their discovery in 1993, emerging evidence shows that altered abundances of miRNAs are associated with cancer, such as ESCC [16][17][18], liver cancer [19][20][21] and breast cancer [22][23][24]. miRNAs are detectable in plasma in a remarkably stable form that is often resistant to RNase digestions [25], making circulating miRNAs ideal candidates to serve as biomarkers for cancer detection.…”