MicroRNA-17 acts as a tumor chemosensitizer by targeting JAB1/CSN5 in triple-negative breast cancer

Wang, Sumei; Oh, Do Youn; Leventaki, Vasiliki; Δράκος, Ηλίας; Zhang, Ronghua; Şahin, Ayşegül; Resetkova, Erika; Edgerton, Mary E.; Wu, Wanyin; Claret, François X.

doi:10.1016/j.canlet.2019.08.016

Cited by 23 publications

(13 citation statements)

References 39 publications

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“… 37 Various studies have confirmed that COPS5 is highly expressed in ovarian cancer, breast cancer, lung cancer, hepatocellular carcinoma, and osteosarcoma and is associated with tumor progression and poor prognosis. 38 , 39 , 40 , 41 , 42 In this study, we revealed that COPS5 regulated the expression of TRIM24 protein at the post-transcriptional level rather than at the transcriptional level. Through coIP experiments, we confirmed that COPS5 interacted with TRIM24, which was dependent on PVT1 .…”

Section: Discussionmentioning

confidence: 64%

RETRACTED: LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24

Jin

Miao

et al. 2022

Molecular Therapy - Nucleic Acids

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LncRNA PVT1 has been implicated in numerous pathophysiological processes and diseases, especially cancers. However, the role and mechanism of PVT1 in the tumorigenesis of glioblastoma remain unclear. We investigated the alteration of PVT1 and its key functions in glioblastoma. PVT1 was upregulated and associated with poor prognosis in glioblastoma. We demonstrated that PVT1 silencing suppressed cell proliferation, colony formation, and orthotopic xenograft tumor growth. Mechanistic investigations found that PVT1 interacted with TRIM24 directly and increased its protein stability. PVT1 recruited COPS5 to deubiquitinate TRIM24; reciprocally, PVT1 depletion impaired the interaction between COPS5 and TRIM24, resulting in decreased expression of TRIM24. PVT1 , TRIM24, and COPS5 coordinately contributed to the activation of STAT3 signaling and malignant phenotype of glioblastoma. Collectively, this study elucidates the essential role of PVT1 in the tumorigenesis of glioblastoma, which provides candidacy therapeutic target for glioblastoma treatment.

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Section: Discussionmentioning

confidence: 64%

RETRACTED: LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24

Jin

Miao

et al. 2022

Molecular Therapy - Nucleic Acids

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“…As one of the hub genes of breast cancer prognosis, COPS5, also known as JAB1 or CSN5, was initially identified as c-Jun activation domain-binding protein-1 and is aberrantly overexpressed in various human cancers including breast cancer. Previous studies have demonstrated that COPS5 is involved in controlling cell proliferation, cell cycle, apoptosis, DNA damage response, and drug resistance, which are critical processes in tumorigenesis (26)(27)(28)(29). The TF-target gene network showed that the target genes of COPS5 in breast cancer were CDKN1B and VEGFA (Figure 5C), which were suggested to block G1 growth induced by COPS5 in MDA-MB-453 cells (30), promote breast cancer progress via the HIF1A signaling pathway, and degrade p53 (31).…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Transcription Factors and Immune Infiltration Patterns Associated With Breast Cancer Prognosis Using WGCNA and Cox Regression Analysis

et al. 2021

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Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death among women worldwide. Therefore, the need for effective breast cancer treatment is urgent. Transcription factors (TFs) directly participate in gene transcription, and their dysregulation plays a key role in breast cancer. Our study identified 459 differentially expressed TFs between tumor and normal samples from The Cancer Genome Atlas database. Based on gene expression analysis and weighted gene co-expression network analysis, the co-expression yellow module was found to be integral for breast cancer progression. A total of 121 genes in the yellow module were used for function enrichment. To further confirm prognosis-related TFs, COX regression and LASSO analyses were performed; consequently, a prognostic risk model was constructed, and its validity was verified. Ten prognosis-related TFs were identified according to their expression profile, survival probability, and target genes. COPS5, HDAC2, and NONO were recognized as hub TFs in breast cancer. These TFs were highly expressed in human breast cancer cell lines and clinical breast cancer samples; this result was consistent with the information from multiple databases. Immune infiltration analysis revealed that the proportions of resting dendritic and mast cells were greater in the low-risk group than those in the high-risk group. Thus, in this study, we identified three hub biomarkers related to breast cancer prognosis. The results provide a framework for the co-expression of TF modules and immune infiltration in breast cancer.

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“…The high expression of miRNA-17-5p is significantly associated with the progression of various cancers probably through increasing the expression of p53 (Thompson et al, 2016;Duan et al, 2018). However, miRNA-17-5p also reportedly acts as a tumor suppressor in triple-negative breast cancer, which is the breast cancer subtype with the poorest prognosis (Wang et al, 2019). Aberrant expression of miRNA-92a has been reported in various tumors and as such has potential value as a tumor marker or novel target for cancer treatment (Li et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis of MicroRNA and Gene Interactions for Revealing Candidate Signatures in Prostate Cancer

et al. 2020

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MicroRNA (miRNA)-gene interactions are well-recognized as involved in the progression of almost all cancer types including prostate cancer, which is one of the most common cancers in men. This study explored the significantly dysregulated genes and miRNAs and elucidated the potential miRNA-gene regulatory network in prostate cancer. Integrative analysis of prostate cancer and normal prostate transcriptomic data in The Cancer Genome Atlas dataset was conducted using both differential expression analysis and weighted correlation network analysis (WGCNA). Thirteen genes (RRM2,

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MicroRNA-17 acts as a tumor chemosensitizer by targeting JAB1/CSN5 in triple-negative breast cancer

Cited by 23 publications

References 39 publications

RETRACTED: LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24

RETRACTED: LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24

Identification of Key Transcription Factors and Immune Infiltration Patterns Associated With Breast Cancer Prognosis Using WGCNA and Cox Regression Analysis

Integrative Analysis of MicroRNA and Gene Interactions for Revealing Candidate Signatures in Prostate Cancer

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