MicroRNA 17–92 expressed by a transposone‐based vector changes expression level of cell‐cycle‐related genes

Attar, Marzieh; Arefian, Ehsan; Nabiuni, Mohammad; Adegani, Fatemeh Jamshidi; Aghaee‐Bakhtiari, Seyed Hamid; Karimi, Zahra; Barzegar, Mansoureh; Soleimani, Masoud

doi:10.1002/j.1095-8355.2012.tb03408.x

Cited by 4 publications

(4 citation statements)

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“…Hence a single miRNA could target more than several hundred mRNAs . Numerous reports demonstrated that miRNAs playing central characters in regulation of several signaling pathways and biological processes encompassing differentiation, angiogenesis, and cell cycle . In normal physiologic conditions, miRNAs are integral parts of feedback circuits and play a fundamental role in buffering of biological processes; however, improper expression of miRNA may affect various types of transcription factor and signaling pathways involved in cancer development .…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as potential therapeutic targets to predict responses to oxaliplatin in colorectal cancer: From basic evidence to therapeutic implication

et al. 2019

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Colorectal cancer (CRC) is one of the most common malignancies with poor prognosis. Oxaliplatin‐based chemotherapy is an important treatment for CRC; however, the cells develop resistance to therapy. The mechanisms underlying oxaliplatin resistance are complex and unclear. There is increasing evidence that microRNAs (miRNAs) (i.e., miR‐34a, miR‐143, miR‐153, miR‐27a, miR‐218, and miR‐520) play an essential role in tumorigenesis and chemotherapy resistance, by targeting various cellular and molecular pathways (i.e., PI3K/Akt/Wnt, EMT, p53, p21, and ATM) that are involved in the pathogenesis of CRC. Identifying the miRNAs that are involved in chemo‐resistance, and their function, may help as a potential therapeutic option for treatment of CRC or as potential prognostic biomarker. Here, we summarized the clinical impact of miRNAs that have critical roles in the development of resistance to oxaliplatin in CRC.

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Section: Introductionmentioning

confidence: 99%

MicroRNAs as potential therapeutic targets to predict responses to oxaliplatin in colorectal cancer: From basic evidence to therapeutic implication

et al. 2019

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“…The role of miRNAs in human cancer pathogenesis has been well proven by identification of the genetic alterations in miRNA loci, miRNA expression profiles and many oncogenes and tumor suppressor genes as miRNA targets (Nicoloso et al, 2010). miRNAs bind to the 3′-UTRs of mRNAs, thereby interfering with translation and regulating cell functions including differentiation, cell cycle regulation and cell propagation (Attar et al, 2012;Moradi-Marjaneh et al, 2018;Zare et al, 2015). They recognize their target mRNAs mainly by base-pairing interaction between the seed region (nucleotides 2-8) from its 5′-end (5′-UTR) and the complementary nucleotides on the 3′-UTR of target mRNAs (Gong et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

In silico evidence of high frequency of miRNA‐related SNPs in Esophageal Squamous Cell Carcinoma

Rafieenia

Abbaszadegan

Poursheikhani

et al. 2019

Journal Cellular Physiology

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Esophageal squamous cell carcinoma (ESCC) is the dominant histological type of esophageal cancer significantly reported in developing nations. There is an increasing evidence suggesting that single nucleotide polymorphisms (SNPs) in the untranslated regions of genes (3′-UTRs) targeted by microRNAs (miRNAs) can change the target gene's expression and thereby affect the individual's cancer risk. Thus, in support of the role of SNPs occurring in miRNA target sites (miR-TS-SNPs) in the cancer, we analyzed the next generation sequencing data of 10 ESCC patients. In each patient, about 3,000 SNPs in 3′-UTRs were obtained in their whole-exome sequencing profiles. We applied two separate methods, manual and computational in silico approaches, to predict the miR-TS-SNPs with more effects on the miRNA-target interactions. dbSNP, 1000G, ExAC, Iranome, miRandb, miRCancer, TargetScan, Human, miRNASNP2 and miRBase databases were used for positive selection of miR-TS-SNPs and DIANA-miRPath v3.0 for pathway analysis. We identified six rare germline miR-TS-SNPs and two other ones with unknown miR-TS-SNPs. We interestingly observed all of these variants in only one patient, which can be evidence of the relationship between miR-TS-SNPs and cancer incidence. The study of cancer genetics including miR-TS-SNPs reveals miRNAs and their related pathways, which will be greatly useful in cancer research from noninvasive biomarkers to new treatments. K E Y W O R D SESCC, in silico analysis, miR-TS-SNPs, NGS

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“…MicroRNAs (miRNAs) are a group of noncoding RNA molecules, target the 3′-untranslated regions (3′-UTRs) of messenger RNAs (mRNAs) and downregulate gene expression. Several studies have shown that miRNAs have an important role in controlling various biological functions containing apoptosis, cell proliferation, differentiation, cell cycle, and metabolism (Attar et al, 2012;Fallah et al, 2013;Rahimian et al, 2011;Zare et al, 2015). The potential functions of miRNAs have been studied in different types of cancer.…”

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confidence: 99%

The role of microRNAs in 5‐FU resistance of colorectal cancer: Possible mechanisms

Marjaneh

Khazaei

Ferns

et al. 2018

Journal Cellular Physiology

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Colorectal cancer (CRC) is one of the most common cancers globally. Despite recent advances in therapeutic approaches, this cancer continues to have a poor prognosis, particularly when diagnosed late. 5-Fluorouracil (5-FU) has been commonly prescribed for patients with CRC, but resistance to 5-FU is one of the main reasons for failure in the treatment of this condition. Recently, microRNAs (miRNAs) have been established as a means of modifying the signaling pathways involved in initiation and progression of CRC and their role as oncogene or tumor suppressor have been investigated in various studies. Moreover, miRNAs through various mechanisms play an important role in inducing tumor resistance or sensitivity to anticancer drugs. Detecting and targeting these mechanisms may be a new therapeutic approach. This review summarizes the current knowledge about the potential roles of miRNAs in 5-FU resistance, with particular emphasis on molecular mechanism involved.

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MicroRNA 17–92 expressed by a transposone‐based vector changes expression level of cell‐cycle‐related genes

Cited by 4 publications

References 0 publications

MicroRNAs as potential therapeutic targets to predict responses to oxaliplatin in colorectal cancer: From basic evidence to therapeutic implication

MicroRNAs as potential therapeutic targets to predict responses to oxaliplatin in colorectal cancer: From basic evidence to therapeutic implication

In silico evidence of high frequency of miRNA‐related SNPs in Esophageal Squamous Cell Carcinoma

The role of microRNAs in 5‐FU resistance of colorectal cancer: Possible mechanisms

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