MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells

Xia, Hongping; Qi, Yanting; Ng, Sophia; Chen, Xiaona; Chen, Shen; Fang, Marong; Li, Dan; Zhao, Yu; Ge, Ruiguang; Li, Guo; Chen, Yangchao; He, Ming‐Liang; Kung, Hsiang‐Fu; Lai, Lihui; Lin, Marie C.M.

doi:10.1016/j.bbrc.2008.12.169

Cited by 136 publications

(92 citation statements)

References 20 publications

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“…One of these exclusively expressed microRNAs was miR-15b. This microRNA has been shown to be involved in the cell cycle and its over expression results in cell cycle arrest [14]. Another exclusively expressed miRNA in our study was miR-93 which is associated with oxidative stress and was also identified to be further up-regulated with an abnormal chromosome constitution of an aged blastocyst.…”

Section: Discussionmentioning

confidence: 58%

Human blastocysts exhibit unique microRNA profiles in relation to maternal age and chromosome constitution

McCallie

Parks

Loper

et al. 2011

Fertility and Sterility

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Section: Discussionmentioning

confidence: 58%

Human blastocysts exhibit unique microRNA profiles in relation to maternal age and chromosome constitution

McCallie

Parks

Loper

et al. 2011

Fertility and Sterility

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“…Therefore, some DLBCL cell lines of the 'poor' immunophenotype, on the basis of microRNA profiles may be more indolent or conversely, possess a more 'aggressive' phenotype than that expected based on Han's classifier. Thus, the ABC-type HLY-1 showed differential up-regulation of expression of the miR-17-92 cluster, a known oncomiR (27), and also of miR-106A, -106B, -93, -30D, -15B and -103, which are reported to be up-regulated in a variety of aggressive solid cancers or have oncogenic potential (28,29,31,(51)(52)(53). In addition, the ABC-like SU-DHL-8 had a more 'indolent' phenotype compared with the other ABC types.…”

Section: Discussionmentioning

confidence: 97%

A 9 series microRNA signature differentiates between germinal centre and activated B-cell-like diffuse large B-cell lymphoma cell lines

Culpin

Proctor²,

Angus³

et al. 2010

Int J Oncol

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Abstract.The microRNAs are endogenous, non-coding RNAs that play key roles in a range of pathophysiological processes by up-or down-regulating gene expression. Recent studies have shown that some microRNAs have oncogenic or tumour suppressor activity. Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin's lymphoma with a heterogeneous biology, which has impeded the clinical assessment of patients. The currently-used clinically-based IPI provides useful information for treatment decision making, but has limited predictive power. Recent immunohistochemical approaches have identified two different prognostic groups: the more indolent germinal centre (GC)-and the higher risk activated B-cell (ABC)-like phenotypes. Although useful, prediction based on immunophenotype has limitations. The present study uses microRNA profiling and a number of well-characterised B-cell lymphoma cell lines to identify microRNA signatures that are correctly assigned to the DLBCL prognostic subgroups and distinguish DLBCL from other more indolent lymphoma, including follicular lymphoma (FL). MicroRNA microarray analysis was based on miRBase version 12.0 and analysis was performed using an unsupervised hierarchical clustering model. Discriminatory microRNAs were validated by qRT-PCR. We identified a 9 microRNA signature that discriminated between ABC-and GC-like DLBCL. This included 3 newly identified microRNAs, not previously associated with DLBCL and predicted to target genes that are de-regulated in lymphoma. DLBCL was distinguished from FL by 4 microRNAs and a total of 18 microRNAs were identified that differentiated between all lymphoma and control populations. Most of the discriminatory microRNAs have been reported previously to be known oncomiRs or act as tumour suppressors. In conclusion, the present study identified a microRNA signature that correctly classified GC and ABC phenotypes in DLBCL cell lines. This signature has yet to be assessed for prediction in clinical samples.

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“…We identified several tumor-suppressor miRNAs which were down-regulated following 1386A treatment, including miR-15, miR-16 and the miR-let-7 family, which potentially function by targeting oncogenes or suppressor genes involved in cell cycle and apoptosis. It was reported that miR-15/16 suppresses tumorigenicity, inhibits proliferation (42,43) and causes cell cycle arrest (44), and also modulates multidrug resistance by targeting the bcl2 gene (35). Additionally, miRNA let-7a has been found to be a tumor-suppressor miRNA by targeting the oncogenes high mobility group AT-hook 2 (HMGA2), KRAS and Myc (45)(46)(47).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells

Cited by 136 publications

References 20 publications

Human blastocysts exhibit unique microRNA profiles in relation to maternal age and chromosome constitution

Human blastocysts exhibit unique microRNA profiles in relation to maternal age and chromosome constitution

A 9 series microRNA signature differentiates between germinal centre and activated B-cell-like diffuse large B-cell lymphoma cell lines

Marine fungal metabolite 1386A alters the microRNA profile in MCF-7 breast cancer cells

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