MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1

Dai, Yuxiang; Qiu, Zhihua; Diao, Zongli; Shen, Li; Xue, Pingping; Sun, Haixiang; Hu, Yali

doi:10.1016/j.placenta.2012.07.012

Cited by 104 publications

(79 citation statements)

References 28 publications

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“…miR-675 therefore may highly affect placental growth through IGF signaling [32]. Furthermore, miR-155 restricts trophoblast cell proliferation by targeting Cycline D1 [33]. Similarly, miR-29b targets MCL1, a Bcl-2 family member, resulting in activation of apoptosis [34].…”

Section: Individual Mirnas Implicated In Proliferation and Apoptosis Ofmentioning

confidence: 99%

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miRNAs in pregnancy-related complications

Lycoudi

Mavreli

Mavrou

et al. 2015

Expert Review of Molecular Diagnostics

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MicroRNAs (miRNAs) constitute a highly conserved class of small non-coding RNAs, involved in post-transcriptional regulation processes by modifying the expression of specific mRNAs. During placental development, cell differentiation, adhesion, migration, apoptosis and angiogenesis are regulated by specific miRNAs and aberrant expression has been associated with the pathogenesis of pregnancy-related complications. Recent studies focusing on placental and maternal peripheral blood miRNA profiling showed different expression between normal and complicated pregnancies, providing valuable information about the pathophysiological role of miRNAs and identifying potential biomarkers for monitoring pregnancy complications. This review summarizes the current knowledge in the field and presents the possible use of miRNAs as biomarkers for early detection and monitoring of these complications.

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Section: Individual Mirnas Implicated In Proliferation and Apoptosis Ofmentioning

confidence: 99%

“…miR-16, miR-20b and miR-29b negatively regulate the VEGF pathway, whereas miR-20b indirectly regulates VEGF through inactivation of EPHB2 (ephrin receptor B2) and EPHB4 [43]. mir-155 targets CYR61 (cysteine-rich angiogenic inducer 61) and reduces cell adhesion [33].…”

Section: Angiogenesismentioning

confidence: 99%

miRNAs in pregnancy-related complications

Lycoudi

Mavreli

Mavrou

et al. 2015

Expert Review of Molecular Diagnostics

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“…Since the TE cells of twin embryos express dual markers of both ICM and TE [9], such discrepancy in miRNA profile may not come as a surprise. miR-155, specifically detected in SBM of twin embryos, inhibits proliferation and migration of trophoblast-derived cell lines [32], whereas nothing is known about potential roles of the other ten ''twin-specific'' miRNAs in human preimplantation embryo development. Although some information concerning their potential roles in cancer diagnosis, prognosis, and therapy has been reported, extrapolating these data to draw conclusions on their function in embryo development would currently be too speculative.…”

Section: Microrna Profile In Sbms Is Similar Among Twins a And B Butmentioning

confidence: 99%

Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c

Noli

Capalbo

Dajani

et al. 2016

Stem Cells and Development

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Studies reporting term pregnancy and the production of genetically identical offspring from isolated blastomeres of early stage embryos have been carried out in small and large animals. However, very little is known about the effects of embryo splitting on the development and reproductive competency of human embryos. In this study, we investigated the effects of embryo splitting on profile of microRNAs (miRNAs) detected in their spent blastocyst medium (SBM) by comparative analysis of miRNA profiles in SBM of human twin embryos created by blastomere biopsy and SBM of blastocysts that resulted in a healthy pregnancy and live birth following embryo transfer. The profile of miRNA secretion in in vitro culture media consistently distinguishes twin from control embryos. We found that six miRNAs are significantly more abundant in SBM from twin embryos, while nine are significantly more abundant in SBM from euploid implanted blastocysts. These nine include miRNA-30c, a previously reported marker of blastocyst implantation potential. Furthermore, 22.9% of miRNAs secreted by twin embryos were never detected in SBM from normal reproductively competent blastocysts, or from trophectoderm (TE) samples from normal blastocysts donated for the research. The miRNA profile, unique to twin blastocysts, might be a result of differential lineage commitment in these embryos.

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“…Another miRNA that is consistently overexpressed in preeclampsia is miR-155 [32,42,69,72] and studies have indicated that miR-155 is important to the regulation of trophoblast invasion [72,86]. miR-155, a common target of a large range of inflammatory mediators, is able to be upregulated by a range of inflammatory factors including interferon b, lipopolysaccharide, TNF-a, and IL-1b; this occurs via the TLR [87].…”

Section: The Roles Of Mirnas In Trophoblast Proliferation Survival Amentioning

confidence: 99%

“…4). One study found that miR-155 is able to directly target cyclin D1 and that overexpression of miR-155 reduces the level of cyclin D1 protein [86]. Cyclin D1, by facilitating the activation of E2F-responsive genes, is important during cell growth, which includes the promotion of cell migration and the decreasing of cell adhesion.…”

Section: The Roles Of Mirnas In Trophoblast Proliferation Survival Amentioning

confidence: 99%

The role of microRNAs in the proliferation, differentiation, invasion, and apoptosis of trophoblasts during the occurrence of preeclampsia—A systematic review

Harapan

Andalas

2015

Tzu Chi Medical Journal

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Keywords: microRNA miRNA Preeclampsia pathogenesis Trophoblast apoptosis Trophoblast invasiveness a b s t r a c t Objectives: Dysregulation of trophoblast invasion into the decidual stroma and spiral arteries during early gestation is one of the major factors associated with the pathogenesis of preeclampsia. Therefore, the objective of this study was to evaluate, based on recent studies, the role of microRNAs (miRNAs) in trophoblast proliferation, differentiation, invasion, and apoptosis during the early gestation of preeclamptic pregnancies. Materials and methods: This systematic review included articles between 2007 and 2015 that were obtained from the MEDLINE database. The articles were identified by searching using a combination of Medical Subject Headings (MeSH terms), namely "preeclampsia", "pre-eclampsia", "miRNA", and "microRNA". All sources of miRNAs, all types of preeclampsia, and all techniques used when measuring miRNAs were included in the reviewed papers. Results: Confirmed upregulation of miR-125b-1-3p, miR-20a, miR-29b, miR-181a, miR-16, miR-210, and miR-155 and confirmed downregulation of miR-17, miR-19b1, miR-195, miR-378a-5p, miR-376c, and miR-675 were identified as involved in repressing the proliferation, differentiation, and invasion of trophoblast cells. In addition, upregulation of miR-29b and downregulation of miR-378a-5p and miR376c were found to be associated with increased trophoblast cell apoptosis. Conclusion: Overall, miRNAs have been confirmed to be involved in the shallow invasion by trophoblasts into the spiral arteries and decidual stroma during early gestation and these miRNAs are possible promising biomarkers that may help to predict preeclampsia in the future.

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MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1

Cited by 104 publications

References 28 publications

miRNAs in pregnancy-related complications

miRNAs in pregnancy-related complications

Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c

The role of microRNAs in the proliferation, differentiation, invasion, and apoptosis of trophoblasts during the occurrence of preeclampsia—A systematic review

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