MicroRNA‐155 in oral squamous cell carcinoma: Overexpression, localization, and prognostic potential

Shi, Linjun; Zhang, Chenyang; Zhou, Zengtong; Ma, Jingyuan; Liu, Yang; Bao, Zhe-Xuan; Jiang, Wei‐Wen

doi:10.1002/hed.23700

Cited by 46 publications

(30 citation statements)

References 34 publications

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“…A, hsa-mir-21-5p; B, hsa-mir-29b-3p; C, hsa-mir-31-5p; D, hsa-mir-99a-5p; E, hsa-mir-99b-3p; F, hsa-mir-100-5p; and G, hsa-mir-155-5p. 42 In our study, we observed an association of elevated hsamir-155-5p levels with extracapsular extension, suggesting an oncogenic role for hsa-mir-155-5p in oral cancer. A variety of cell culture and clinical studies demonstrate an upregulation of hsamir-155-5p in OSCC/HNSCC tissue and cell lines.…”

Section: Hsa-mir-143-3psupporting

confidence: 57%

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

et al. 2019

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Background MicroRNAs (miRNA) recently evolved as potential cancer biomarkers. Therefore, the aim of the present study was to evaluate the prognostic impact of eight miRNAs connected to oral squamous cell carcinoma (OSCC). Method Expression levels of hsa‐mir‐21‐5p, hsa‐mir‐29b‐3p, hsa‐mir‐31‐5p, hsa‐mir‐99a‐5p, hsa‐mir‐99b‐3p, hsa‐mir‐100‐5p, hsa‐mir‐143‐3p and hsa‐mir‐155‐5p were analyzed in tumor tissue (n = 36) and healthy oral mucosal tissue (n = 17) and correlated with clinical variables. Results of the study cohort were validated in an OSCC cohort of The Cancer Genome Atlas. Results Increased hsa‐mir‐99b‐3p expression level showed a tendency toward advanced tumor stages, and high levels of hsa‐mir‐100‐5p expression were associated with extracapsular extension. While a high expression level of hsa‐mir‐99b‐3p was associated with better survival, a high expression level of hsa‐mir‐100‐5p was correlated with a poorer survival in the study cohort. Conclusion Our results indicate that hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p may serve as novel prognostic biomarkers in OSCC.

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Section: Hsa-mir-143-3psupporting

confidence: 57%

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

et al. 2019

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“…The major difference is that for oral cytology study, the normal group consists of matching healthy subjects, and for the tissue sample study, the normal group are histologically normal adjacent tissues from the same cancer patients. It is worth noting that microRNA dysregulation has also been detected in oral potentially malignant disorders (OPMDs) [15–18], and in the field of cancerizationin [19–22]. The concept of field cancerization, initially introduced by Slaughter et al in 1953 to describe the histologically normal epithelium adjacent to oral cancer that harbors early genetic changes [43], which explains the development of multiple primary tumors and local recurrent cancer.…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies also suggested that microRNA markers may have predictive values for the progression of oral potentially malignant disorders (OPMDs) [15–18]. Furthermore, microRNA dysregulation has also been detected in the field of cancerization [19–22]. As such, microRNA-based molecular analysis can enhance the standard histopathological analysis for early detection and monitoring of field of cancerization which have profound implications for cancer prevention.…”

Section: Introductionmentioning

confidence: 99%

microRNA-21 and microRNA-375 from oral cytology as biomarkers for oral tongue cancer detection

Chen

Cabay

et al. 2016

Oral Oncology

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Objective We previously performed a meta-analysis of microRNA profiling studies on head and neck / oral cancer (HNOC), and identified 11 consistently dysregulated microRNAs in HNOC. Here, we evaluate the diagnostic values of these microRNAs in oral tongue squamous cell carcinoma (OTSCC) using oral cytology samples. Materials and Methods The levels of 11 microRNAs were assessed in 39 oral cytology samples (19 OTSCC and 20 normal subjects), and 10 paired OTSCC and adjacent normal tissues. The predictive power of these microRNAs was analyzed by receiver operating characteristic curve (ROC) and random forest (RF) model. A classification and regression trees (CART) model was generated using miR-21 and miR-375, and further validated using both independent oral cytology validation sample set (14 OTSCC and 11 normal subjects) and tissue validation sample set (12 paired OTSCC and adjacent normal tissues). Results Differential expression of miR-21, miR-100, miR-125b and miR-375 was validated in oral cytology training sample set. Based on the RF model, the combination of miR-21 and miR-375 was selected which provide best prediction of OTSCC. A CART model was constructed using miR-21 and miR-375, and was tested in both oral cytology and tissue validation sample sets. A sensitivity of 100% and specificity of 64% was achieved in distinguishing OTSCC from normal in the oral cytology validation set, and a sensitivity of 83% and specificity of 83% was achieved in the tissue validation set. Conclusion The utility of microRNA from oral cytology samples as biomarkers for OTSCC detection is successfully demonstrated in this study.

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“…Multivariate analysis revealed that serum miR-155 expression level was independent prognostic factors for OS, as well as PFS. miR-155 was found to be overexpressed in various solid tumors, including CRC [9][10][11][12]. Moreover, miR-155 has been shown to enhance tumor invasion and migration, and acts as a mediator of EMT [13].…”

Section: Discussionmentioning

confidence: 98%

Investigation of microRNA-155 as a serum diagnostic and prognostic biomarker for colorectal cancer

Fan²,

Chen

et al. 2014

Tumor Biol.

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The aim of the present study was to explore serum microRNA-155 (miR-155) expression in patients with colorectal cancer (CRC) and examined the potential usefulness of this molecule as a biomarker for diagnosis and prognosis in CRC. Serum samples were obtained between May 2007 and March 2013 from 146 CRC patients and 60 healthy controls. Serum miR-155 expression levels were measured by quantitative real time reverse transcription-polymerase chain reaction (qRT-PCR). Survival curves were obtained using the Kaplan-Meier method and assessed by the log-rank test. The receiver operating characteristic (ROC) curve was used for the prediction of cut-off values of the markers. Serum miR-155 expression level on average was upregulated in CRC patients compared with the matched healthy controls (P < 0.001). ROC curve analysis showed that miR-155 was a useful marker for discriminating cases from healthy controls, with an area under the ROC curve (AUC) of 0.776 (95% confidence interval (CI) 0.714 to 0.837, P < 0.001). Kaplan-Meier analysis with the log-rank test indicated that high serum miR-155 expression had a significant impact on overall survival (38.2 vs. 69.9%; P < 0.001) and progression-free survival (34.8 vs. 66.0%; P < 0.001). In conclusion, the detection of miR-155 levels in the serum might serve as a new tumor biomarker in the diagnosis and assessment of prognosis of CRC.

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MicroRNA‐155 in oral squamous cell carcinoma: Overexpression, localization, and prognostic potential

Abstract: MiRNA-155 was overexpressed in OSCC and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC. High miRNA-155 expression level in ACF may predict poor prognosis in patients with OSCC.

Cited by 46 publications

References 34 publications

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer

microRNA-21 and microRNA-375 from oral cytology as biomarkers for oral tongue cancer detection

Investigation of microRNA-155 as a serum diagnostic and prognostic biomarker for colorectal cancer

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