MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1

Yao, Lin-Ya; Ma, Jun; Zeng, Xueming; Ouyang, Jingping

doi:10.3892/ol.2020.12215

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…miR-155 exerts different biological functions in different cell types and disease models. In certain tumors, it acts as an oncogene to promote cell proliferation, invasion, and metastasis (55)(56)(57)(58), whereas, in other tumors, it acts as a tumor suppressor to inhibit cell proliferation and promote apoptosis (59,60). Li et al (61) reported that triptolide could significantly induce the expression of miR-155 both in normal human hepatocytes and in rodent liver tissues, and inhibition of miR-155 mitigated the hepatic damage caused by triptolide.…”

Section: Discussionmentioning

confidence: 99%

Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis

et al. 2023

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Diabetic liver injury (DLI) can result in several diseases of the liver, including steatohepatitis, liver fibrosis, cirrhosis, and liver cancer. Low-dose ionizing radiation (LDIR) has hormetic effects in normal/disease conditions. However, whether LDIR has a beneficial effect on DLI has not been assessed previously. MicroRNA (miR)-155 and its target gene suppressor of cytokine signaling 1 (SOCS1) play critical roles in modulating hepatic proliferation, apoptosis, and immunity. However, whether a miR-155-SOCS1 axis is involved in high glucose (HG) induced hepatic damage remains to be determined. In the present study, mouse hepatocyte AML12 cells were treated with 30 mM glucose (HG), 75 mGy X-ray (LDIR), or HG plus LDIR. The expression levels of miR-155 and SOCS1 were determined by reverse transcription-quantitative PCR and western blotting. Additionally, apoptosis was measured using flow cytometry. The release of inflammatory factors, including TNF-α, IL-1β, IL-6, IL-10, and IFN-γ, after HG and/or LDIR treatment was detected by ELISA. The results showed that HG may induce hepatic apoptosis by upregulating the levels of miR-155 and downregulating the levels of SOCS1. HG also stimulated the secretion of TNF-α, IL-1β, IL-6, and IL-10. However, LDIR blocked the HG-induced activation of a miR-155-SOCS1 axis and suppressed the release of inflammatory factors. These results indicated that a miR-155-SOCS1 axis plays a role in HG-induced liver injury, and LDIR may exert a hepatoprotective effect by regulating the miR-155-SOCS1 axis.

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Section: Discussionmentioning

confidence: 99%

Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis

et al. 2023

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“…However, cell-free and EV-derived miRNAs do not necessarily show the same expression profiles in urine [ 65 ]. miR-155-5p has been found to inhibit the migration of prostate cancer cells [ 66 ] and a potential target for antitumoral treatments [ 67 ]. It has also been proposed that downregulation of miR-186-5p promotes cell proliferation and invasion due to its effect on Twist1 [ 68 ], and low levels of miR-186-5p have also been linked to other tumours such as colorectal and esophageal cancer [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients

et al. 2021

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Background Active surveillance is an alternative to radical treatment for patients with low-risk prostate cancer, which could also benefit some patients with intermediate risk. We have investigated the use of miRNA in urinary extracellular vesicles to stratify these patients. Methods NGS was performed to profile the miRNAs from small urinary extracellular vesicles in a cohort of 70 patients with prostate cancer ISUP Grade 1, 2 or 3. The most promising candidates were then analysed by RT-qPCR in a new cohort of 60 patients. Results NGS analysis identified nine miRNAs differentially expressed in at least one of the comparisons. The largest differences were found with miR-1290 (Grade 3 vs. 1), miR-320a-3p (Grade 3 vs. 2) and miR-155-5p (Grade 2 vs. 1). Combinations of 2–3 miRNAs were able to differentiate between two ISUP grades with an AUC 0.79–0.88. RT-qPCR analysis showed a similar trend for miR-186-5p and miR-30e-5p to separate Grade 3 from 2, and miR-320a-3p to separate Grade 2 from 1. Conclusions Using NGS, we have identified several miRNAs that discriminate between prostate cancer patients with ISUP Grades 1, 2 and 3. Moreover, miR-186-5p, miR-320a-3p and miR-30e-5p showed a similar behaviour in an independent cohort using an alternative analytical method. Our results show that miRNAs from urinary vesicles can be potentially useful as liquid biopsies for active surveillance.

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“…miR-454 is highly expressed in PCa and targets the well-known tumor suppressor Nmyc downstream-regulated gene 2 (NDRG2) which consequently induces proliferation and invasion of PCa cells [74]. miR-454 was also shown to activate WNT/ß-catenin signaling which is able to interact with Ras so that miR-454 might contribute to bone metastasis in PCa via these pathways [99]. Its potential as therapeutic target is consistently suggested [100], but not well-validated in PCa yet.…”

Section: Mir-454mentioning

confidence: 99%

Role of Metastasis-Related microRNAs in Prostate Cancer Progression and Treatment

Oh‐Hohenhorst

Lange

2021

Cancers

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Prostate cancer (PCa) is one of the most prevalent cancer types in males and the consequences of its distant metastatic deposits are the leading cause of PCa mortality. Therefore, identifying the causes and molecular mechanisms of hematogenous metastasis formation is of considerable clinical importance for the future development of improved therapeutic approaches. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level by targeting messenger RNAs. Numerous studies have identified miRNAs as promotors or inhibitors of metastasis and revealed, in part, their targeting pathways in PCa. Because miRNAs are remarkably stable and can be detected in both tissue and body fluid, its potential as specific biomarkers for metastasis and therapeutic response is also currently under preclinical evaluation. In the present review, we focus on miRNAs that are supposed to initiate or suppress metastasis by targeting several key mRNAs in PCa. Metastasis-suppressing miRNAs include miR-33a-5p, miR-34, miR-132 and miR-212, miR-145, the miR-200 family (incl. miR-141-3p), miR-204-5p, miR-532-3p, miR-335, miR-543, miR-505-3p, miR 19a 3p, miR-802, miR-940, and miR-3622a. Metastasis-promoting RNAs, such as miR-9, miR-181a, miR-210-3, miR-454, miR-671-5p, have been shown to increase the metastatic potential of PCa cells. Other metastasis-related miRNAs with conflicting reports in the literature are also discussed (miR-21 and miR-186). Finally, we summarize the recent developments of miRNA-based therapeutic approaches, as well as current limitations in PCa. Taken together, the metastasis-controlling miRNAs provide the potential to be integrated in the strategy of diagnosis, prognosis, and treatment of metastatic PCa. Nevertheless, there is still a lack of consistency between certain miRNA signatures and reproducibility, which impedes clinical implementation.

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MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1

Cited by 7 publications

References 29 publications

Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis

Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis

Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients

Role of Metastasis-Related microRNAs in Prostate Cancer Progression and Treatment

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