MicroRNA-154 as a prognostic factor in bladder cancer inhibits cellular malignancy by targeting RSF1 and RUNX2

Zhao, Xin; Ji, Zhigang; Xie, Yi; Liu, Guanghua; Li, Hanzhong

doi:10.3892/or.2017.5992

Cited by 28 publications

(35 citation statements)

References 39 publications

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“…In the present study, we found marked downregulation of miR-154 in BCa tissues and cell lines, which was consistent with the results of a previous study (15). Moreover, a decreased miR-154 level was correlated with aggressive clinicopathological features, including advanced T stage, lymphatic invasion, and distant metastasis.…”

Section: Discussionsupporting

confidence: 93%

“…For example, miR-145 (8), miR-122 (9) and miR-31 (10) have been revealed to influence tumorigenesis, tumor proliferation, invasion and metastasis. Several studies have also revealed that miR-154 acts as a tumor suppressor in a wide variety of human cancers, including prostate (11), colorectal (12), breast (13), liver (14) and BCa (15). However, the role of miR-154 in BCa progression has not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7

et al. 2018

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Aberrant expression of miR-154 is usually found in cancer studies; however, the role of miR-154 has seldom been reported in bladder cancer (BCa). In this study, we observed that miR-154 expression was significantly downregulated in BCa tissues and cell lines, and was associated with several clinicopathological characteristics, including advanced T stage, lymphatic invasion, and distant metastasis. Low expression level of miR-154 was associated with poor survival outcomes in BCa patients. Overexpression of miR-154 led to significant decrease in the proliferation, migration, and invasion of BCa cells, while knockdown of miR-154 yielded the opposite effect. ATG7 was identified as a direct target of miR-154. ATG7 expression was negatively correlated with miR-154 expression in BCa tissues. Silencing of ATG7 achieved a similar effect to miR-154 overexpression; overexpression of ATG7 reversed the inhibitory effect of miR-154 on BCa cell proliferation, migration and invasion. A xenograft study revealed that miR-154 inhibited BCa cell growth in vivo, and suppressed ATG7 expression. Altogether, this study demonstrated that miR-154 may function as a tumor suppressor in BCa and indicated that miR-154 may be a potential therapeutic target for BCa patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7

et al. 2018

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“…Consistently, the studies conducted by Zhao et al and Zhang et al demonstrated that miR-154 was downregulated in bladder cancer tissue samples and cell lines. 39 , 40 According to Zhao et al’s experiments, miR-154 acts as a prognostic factor and can suppress bladder cancer by directly targeting RSF1 and RUNX2. 40 In agreement, Zhang et al reported that miR-154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7.…”

Section: Mir-154 and Genitourinary System Cancersmentioning

confidence: 99%

“…39 , 40 According to Zhao et al’s experiments, miR-154 acts as a prognostic factor and can suppress bladder cancer by directly targeting RSF1 and RUNX2. 40 In agreement, Zhang et al reported that miR-154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7. 39 Investigating the role of miR-154 in cervical cancer, Wu et al, found that the decreased expression level of miR-154 was significantly associated with clinicopathological features including lymph node metastasis, vascular invasion, poor tumor differentiation, advanced FIGO stage, and short overall survival.…”

Section: Mir-154 and Genitourinary System Cancersmentioning

confidence: 99%

<p>MicroRNA-154: A Novel Candidate for Diagnosis and Therapy of Human Cancers</p>

Nazarizadeh¹,

Mohammadi²,

Alian³

et al. 2020

OTT

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MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded, tiny RNAs with 21-23 nucleotides that regulate several biological functions through binding to target mRNAs and modulating gene expression at post-transcriptional levels. Recent studies have described crucial roles for miRNAs in pathophysiology of numerous human cancers. They can act as an oncogene and promote cancer or as a tumor suppressor and alleviate the disease. Recently discovered microRNA-154 (miR-154) has been proposed to be involved in multiple physiological and pathological processes including cancer. With this aspect, aberrant expression of miR-154 has been demonstrated in variety of human malignancies, suggesting an important role for miR-154 in tumorigenesis. To be specific, it is considered as a tumor suppressor miRNA and exerts its beneficial effects by targeting several genes. This review systematically summarizes the recent advances done on the role of miR-154 in different cancers and discusses its potential prognostic, diagnostic and therapeutic values.

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“…MicroRNAs (miRNAs) are key regulators in post-transcriptional suppression. They are small non-coding RNAs, approximately 22 nucleotides in length 11 . Their aberrant expression has been recently used as novel biomarkers detected in the urine of BBC and NBBC patients 12 .…”

Section: Introductionmentioning

confidence: 99%

Role of a schistosoma haematobium specific microRNA as a predictive and prognostic tool for bilharzial bladder cancer in Egypt

Gaber

Wassef

Elayat

et al. 2020

Sci Rep

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Urinary bladder cancer is a common malignancy in Egypt, thus reliable methodologies are required for screening and early detection. In this study, we analyzed the gene expression of a Schistosoma hematobium specific microRNA “Sha-miR-71a” and mitogen-associated protein kinase-3 (MAPK-3) in the urine samples of 50 bladder cancer patients and 50 patients with benign bilharzial cystitis. Fifty control subjects were also tested. Indirect hemagglutination test (IHA) diagnosed 70% of studied cancer cases as bilharzial associated bladder cancer (BBC), while histopathological examination detected only 18%. Urinary Sha-miR-71a & MAPK-3 revealed enhanced expression in BBC (p-value = 0.001) compared to non-bilharzial bladder cancer (NBBC) cases. Patients with chronic bilharzial cystitis exhibited a significant increase in gene expression compared to those with acute infection (p-value = 0.001). Sha-miR-71a and MAPK-3 showed good sensitivity and specificity in the diagnosis of BBC when analyzed by the receiver operating characteristic (ROC) curve. They were also prognostic regarding malignancy grade. Both biomarkers showed a positive correlation. Our results revealed that IHA is a reliable test in the diagnosis of bilharziasis associated with bladder cancer, and that Sha-miR-71a and MAPK-3 provide non-invasive specific biomarkers to diagnose BBC, as well as a potential role in testing bilharzial patients for risk to develop cancer.

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MicroRNA-154 as a prognostic factor in bladder cancer inhibits cellular malignancy by targeting RSF1 and RUNX2

Cited by 28 publications

References 39 publications

MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7

MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7

<p>MicroRNA-154: A Novel Candidate for Diagnosis and Therapy of Human Cancers</p>

Role of a schistosoma haematobium specific microRNA as a predictive and prognostic tool for bilharzial bladder cancer in Egypt

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